| Related LncRNAs | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| ID | lncRNA Name | Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source |
| EL0036 | AF086415 | nasopharyngeal carcinoma | microarray, qPCR, knockdown etc. | nasopharyngeal carcinoma tissue, cell lines (CNE-2 etc.) | down-regulated | expression | Six lncRNAs (AF086415, AK095147, RP1-179N16.3, MUDENG, AK056098 and AK294004) were confirmed by qPCR. | 24379026 | LncRNADisease Lnc2Cancer |
| EL0040 | AFAP1-AS1 | nasopharyngeal carcinoma | microarray, qPCR, Western blot, knockdown, ISH etc. | NPC tissue, cell lines (5-8F, HNE2, HK-1) | up-regulated | interaction | AFAP1-AS1 expression was upregulated in NPC and associated with NPC metastasis and poor prognosis. In vitro experiments demonstrated that AFAP1-AS1 knockdown significantly inhibited the NPC cell migration and invasive capability. AFAP1-AS1 knockdown also increased AFAP1 protein expression. Proteomic and bioinformatics analyses suggested that AFAP1-AS1 affected the expression of several small GTPase family members and molecules in the actin cytokeratin signaling pathway. AFAP1-AS1 promoted cancer cell metastasis via regulation of actin filament integrity. | 26246469 | Lnc2Cancer |
| EL0056 | AK095147 | nasopharyngeal carcinoma | microarray, qPCR, knockdown etc. | nasopharyngeal carcinoma tissue, cell lines (CNE-2 etc.) | down-regulated | expression | Six lncRNAs (AF086415, AK095147, RP1-179N16.3, MUDENG, AK056098 and AK294005) were confirmed by qPCR. | 24379026 | LncRNADisease Lnc2Cancer |
| EL0079 | AP5M1 | nasopharyngeal carcinoma | microarray, qPCR, knockdown etc. | nasopharyngeal carcinoma tissue, cell lines (CNE-2 etc.) | up-regulated | expression | Six lncRNAs (AF086415, AK095147, RP1-179N16.3, MUDENG, AK056098 and AK294007) were confirmed by qPCR. | 24379026 | LncRNADisease Lnc2Cancer |
| EL0289 | CDKN2B-AS1 | nasopharyngeal carcinoma | N/A | N/A | N/A | mutation | A SNP rs1412829 (C49137T) at CDKN2A-CDKN2B gene cluster on 9p21 is associated with this disease. | 20512145 | LncRNADisease |
| EL0289 | CDKN2B-AS1 | nasopharyngeal carcinoma | N/A | N/A | N/A | mutation | More recently, additional GWAS identified ANRIL as a risk locus (rs3217992, A>G;rs1063192, C>T) for several cancers including breast cancer, nasopharyngeal carcinoma, basal cell carcinoma, and glioma. | 20956613 | LncRNADisease |
| EL0289 | CDKN2B-AS1 | nasopharyngeal carcinoma | N/A | N/A | N/A | locus | A genetic susceptibility locus. | 20956613 | LncRNADisease |
| EL0289 | CDKN2B-AS1 | nasopharyngeal carcinoma | N/A | N/A | N/A | mutation | In recent years, GWAS has identified ANRIL as a risk locus for NPC and other cancers. | 24817925 | LncRNADisease |
| EL0556 | H19 | nasopharyngeal carcinoma | knockdown | NPC tissues | up-regulated | N/A | H19 regulated EZH2 expression suppressing the activity of miR-630 | 27040767 | |
| EL0575 | HNF1A-AS1 | nasopharyngeal carcinoma | knockdown, colony-formation, wound-healing, and transwell assays, cell cycle analysis, western blot analysis | tumor tissues from 20 patients with nasopharyngeal carcinoma (NPC) as well as from cultured NPC cell lines | N/A | expression | LncRNA, HNF1A-AS potentially regulates NPC tumorigenesis. HNF1A-AS was found to be associated with epithelial to mesenchymal transition. | 26756620 | |
| EL0578 | HOTAIR | nasopharyngeal carcinoma | knockdown | nasopharyngeal carcinoma cells | up-regulated | interaction | Hotair knockdown significantly attenuated both in vitro and in vivo tumor cell growth and angiogenesis. | 26717040 | |
| EL0578 | HOTAIR | nasopharyngeal carcinoma | N/A | N/A | N/A | expression | The result showed that, the expression levels of HOTAIR wereup-regulated in NPC tissues than in non-cancerous tissues. Further study demonstrated that HOTAIR was up-regulated in NPC cell lines with high invasive potential and the capacity for migration, invasion and proliferation was suppressed after knocking down HOTAIR expression. | 24817925 | LncRNADisease |
| EL0578 | HOTAIR | nasopharyngeal carcinoma | qPCR, ISH etc. | primary NPC tissue | up-regulated | N/A | Quantified using qPCR, HOTAIR expression levels in fresh tissue and paraffin-embedded samples were 5.2 ~ 48.4-fold higher compared with non-cancer tissue samples. Moreover, HOTAIR expression levels increased with clinical stage progression, which was consistent with ISH findings in the paraffin-embedded tissue. Most importantly, NPC patients with higher HOTAIR levels had a poor prognosis for overall survival using univariate and multivariate analysis. In addition, HOTAIR mediated the migration, invasion and proliferation of NPC cells in vitro. | 23281836 | Lnc2Cancer |
| EL0654 | LINC00312 | nasopharyngeal carcinoma | microarray, ISH etc. | NPC, TMA tissue | down-regulated | expression | Expression of LINC00312, a long intergenic non-coding RNA, is negatively correlated with tumor size but positively correlated with lymph node metastasis in nasopharyngeal carcinoma. | 23529758 | LncRNADisease Lnc2Cancer |
| EL0654 | LINC00312 | nasopharyngeal carcinoma | N/A | N/A | N/A | expression | NAG-7 is a novel gene downregulated in human nasopharyngeal carcinoma. | 11780420 | LncRNADisease |
| EL0654 | LINC00312 | nasopharyngeal carcinoma | Northern blot, Western blot etc. | HNE1 cell line | down-regulated | expression | NAG7 (LINC00312) gene re-expression could inhibit overproliferation of NPC cell by delaying the progression of G1 into S in cell cycle and inducing cell apoptosis. | 12452030 | LncRNADisease Lnc2Cancer |
| EL0654 | LINC00312 | nasopharyngeal carcinoma | qPCR, Western blot, Luciferase reporter assay, ISH etc. | cell line (HNE1) | up-regulated | Interaction | NAG7 (LINC00312) promotes human nasopharyngeal carcinoma invasion through inhibition of estrogen receptor alpha and up-regulation of JNK2/AP-1/MMP1 pathways. | 19591174 | LncRNADisease Lnc2Cancer |
| EL0692 | LINC01315 | nasopharyngeal carcinoma | microarray, qPCR etc. | NPC tissue | up-regulated | expression | Results. In primary NPC, upregulation of?lnc-C22orf32-1,?lnc-AL355149.1-1, and?lnc-ZNF674-1 was observed. High levels of?lnc-C22orf32-1 and?lnc-AL355149.1-1 were significantly associated with the male patients | 24822202 | LncRNADisease Lnc2Cancer |
| EL0762 | lnc-AL355149.1-1 | nasopharyngeal carcinoma | microarray, qPCR etc. | NPC tissue | up-regulated | expression | Results. In primary NPC, upregulation of?lnc-C22orf32-1,?lnc-AL355149.1-1, and?lnc-ZNF674-1 was observed. High levels of?lnc-C22orf32-1 and?lnc-AL355149.1-1 were significantly associated with the male patients | 24822202 | LncRNADisease Lnc2Cancer |
| EL0811 | lnc-ZNF674-1 | nasopharyngeal carcinoma | microarray, qPCR etc. | NPC tissue | up-regulated | expression | Results. In primary NPC, upregulation of?lnc-C22orf32-1,?lnc-AL355149.1-1, and?lnc-ZNF674-1 was observed. High levels of?lnc-C22orf32-1 and?lnc-AL355149.1-1 were significantly associated with the male patients | 24822202 | LncRNADisease Lnc2Cancer |
| EL0831 | LOC401317 | nasopharyngeal carcinoma | microarray, qPCR, Western blot, knockdown, Luciferase reporter assay etc. | cell lines (HNE2, HNE1, CNE2) | up-regulated | regulation | LOC401317 was the most significantly upregulated lncRNA. Further studies indicated that LOC401317 is diretcly regulated by p53 and that etcopic expression of LOC401317 inhibits HNE2 cell proliferation in vitro and in vivo by inducing cell cycle arrest and apoptosis. LOC401317 inhibited cell cycle progression by increasing p21 expression and decreasing cyclin D1 and cyclin E1 expression and promoted apoptosis through the induction of poly(ADP-ribose) polymerase and caspase-3 cleavage. | 25422887 | Lnc2Cancer |
| EL0853 | MALAT1 | nasopharyngeal carcinoma | N/A | N/A | N/A | expression | The result found that MALAT1 was most highly expressed in 5-8F cells (high rate to be tumor and metastasis), and up-regulated in CNE-2, C666-1 and HONE-1 which is higher malignant and poorly differentiated nasopharyngeal squamous cell carcinoma, while least expressed in NP69 epithelial cells of the eternal life. The data indicated that MALAT1 might be related to the metastasis and differentiation of NPC cells. | 24817925 | LncRNADisease |
| EL0853 | MALAT1 | nasopharyngeal carcinoma | qPCR, Western blot, Luciferase reporter assays, RIP etc. | NPC cell lines (5-8F, CNE-2, HONE-1, SUNE-1), NPE cell line (NP-69) | up-regulated | interaction | We found that MALAT1 regulated radioresistance by modulating cancer stem cell (CSC) activity. Furthermore, we found that there was reciprocal repression between MALAT1 and miR-1, and slug was identified as a downstream target of miR-1. Taking these observations into consideration, we proposed that MALAT1 regulated CSC activity and radioresistance by modulating miR-1/slug axis, which indicated that MALAT1 could act as a therapeutic target for NPC patients | 26482776 | Lnc2Cancer |
| EL0853 | MALAT1 | nasopharyngeal carcinoma | qPCR, Western bolt etc. | cell lines (5-8F, 6-10B, CNE-1, CNE-2 etc.) | up-regulated | N/A | MALAT1 was highly expressed in 5-8F cells with a high metastatic potential, and lowly expressed in normal nasopharyngeal epithelium cells. Overexpression of MALAT1 by RNAa suppressed the expression of E-cadherin, promoted the expression of vimentin and enhanced the proliferation, invasion, and metastasis of CNE-1 cells. | 23688988 | Lnc2Cancer |
| EL0973 | NEAT1 | nasopharyngeal carcinoma | N/A | NPC cell lines and tissues | up-regulated | N/A | significantly upregulated in NPC cell lines and tissues | 27020592 | |
| EL0977 | NKILA | nasopharyngeal carcinoma | microarray, qPCR, knockdown etc. | nasopharyngeal carcinoma tissue, cell lines (CNE-2 etc.) | up-regulated | expression | Six lncRNAs (AF086415, AK095147, RP1-179N16.3, MUDENG, AK056098 and AK294008) were confirmed by qPCR. | 24379026 | LncRNADisease Lnc2Cancer |
| EL1007 | NPTN-IT1 | nasopharyngeal carcinoma | qPCR, Western blot, knockdown etc. | NPC tissue, cell lines (CNE2, HNE2) | down-regulated | interaction | We found that lncRNA-LET was significantly downregulated in nasopharyngeal carcinoma (NPC) tissues compared with corresponding normal tissues. Decreased LET expression is significantly correlated with advanced clinical stage, larger tumor size, increased lymph node tumor burden, and poor survival of NPC patients. Knockdown of LET promoted NPC cells proliferation and inhibited cell apoptosis. Importantly, we found lncRNA-LET is transcriptional repressed by EZH2-mediated H3K27 histone methylation on the LET promoter. The expressions of EZH2 and lncRNA-LET are significantly inversely correlated in NPC tissues. | 26243049 | Lnc2Cancer |
| EL1022 | ORAOV1 | nasopharyngeal carcinoma | microarray, qPCR, knockdown etc. | nasopharyngeal carcinoma tissue, cell lines (CNE-2 etc.) | up-regulated | expression | Six lncRNAs (AF086415, AK095147, RP1-179N16.3, MUDENG, AK056098 and AK294009) were confirmed by qPCR. | 24379026 | LncRNADisease Lnc2Cancer |
| EL1155 | Z95152.1 | nasopharyngeal carcinoma | microarray, qPCR, knockdown etc. | nasopharyngeal carcinoma tissue, cell lines (CNE-2 etc.) | up-regulated | expression | Six lncRNAs (AF086415, AK095147, RP1-179N16.3, MUDENG, AK056098 and AK294006) were confirmed by qPCR. | 24379026 | LncRNADisease Lnc2Cancer |