| Related LncRNAs | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| ID | lncRNA Name | Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source |
| EL0224 | BACE1-AS | colon cancer | qPCR etc. | cell lines (SNU-C4R, SNU-C5R etc.) | down-regulated | regulation | We selected three lncRNAs, snaR, BACE1AS, and PRAS, and we detected their expression by RT-qPCR using specific primer sets. SnaR and BACE1AS were significantly down-regulated in both resistant cell lines (SNU-C4R and SNU-C5R), whereas PRAS was down-regulated in SNU-C4R cells but not in SNU-C5R cells. Down-regulation of snaR decreased cell death after 5-FU treatment, which indicates that snaR loss decreases in vitro sensitivity to 5-FU. | 25078450 | Lnc2Cancer |
| EL0276 | CCAT1 | colon cancer | qPCR, ISH etc. | colonic adenoma-carcinoma tissue | up-regulated | N/A | CCAT1 is up-regulated across the colon adenoma-carcinoma sequence. This up-regulation is evident in pre-malignant conditions and through all disease stages, including advanced metastatic disease suggesting a role in both tumorigenesis and the metastatic process. | 23594791 | Lnc2Cancer |
| EL0278 | CCAT2 | colon cancer | qPCR etc. | colon cancer tissue | up-regulated | interaction | Our results revealed that CCAT1 was significantly overexpressed in colon cancer tissues when compared with normal tissues, and its increased expression was correlated with patients' clinical stage, lymph nodes metastasis, and survival time after surgery. Moreover, c-Myc could promote CCAT1 transcription by diretcly binding to its promoter region, and upregulation of CCAT1 expression in colon cancer cells promoted cell proliferation and invasion. | 25185650 | Lnc2Cancer |
| EL0327 | DACOR1 | colon cancer | RNA-seq, qPCR, ChIRP-seq, Western blot, RIP etc. | colon cancer tissue, cell line (HCT116) | down-regulated | interaction | DACOR1 shows high, tissue-specific expression in the normal colon but was repressed in a panel of colon tumors and patient-derived colon cancer cell lines. Induction of DACOR1 in colon cancer cell lines significantly reduced their ability to form colonies in vitro, suggesting a growth suppressor function. Induction of DACOR1 led to the activation of tumor-suppressor pathways and attenuation of cancer-associated metabolic pathways. | 26307088 | Lnc2Cancer |
| EL0556 | H19 | colon cancer | N/A | N/A | N/A | expression | DT-A was preferentially expressed in liver metastases after being transfected with H19 or IGF2-P3 promoter-driven DT-A expression plasmids, causing a very significant inhibition of tumor growth as a result of its cytotoxic effect. | 15521051 | LncRNADisease |
| EL0556 | H19 | colon cancer | N/A | N/A | N/A | N/A | Regional therapy with DTA-H19 vector suppresses growth of colon adenocarcinoma metastases in the rat liver. | 21874233 | LncRNADisease |
| EL0556 | H19 | colon cancer | N/A | N/A | N/A | regulation | Control of imprinting. Containing miRNA miR-675. | 22996375 | LncRNADisease |
| EL0556 | H19 | colon cancer | qPCR, Northern blot, ISH etc. | CRC tissue | up-regulated | locus | Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer. | 19926638 | LncRNADisease Lnc2Cancer |
| EL0578 | HOTAIR | colon cancer | N/A | N/A | N/A | expression | In approximately one-quarter of human breast cancers, HOTAIR is highly induced, while its elevated levels are also predictive of metastasis and disease progression in other cancers, such as colon, colorectal, gastrointestinal, pancreatic and liver cancer. | 24667321 | LncRNADisease |
| EL0578 | HOTAIR | colon cancer | qPCR, Western blot, knockdown etc. | colon cancer tissue, cell lines (SW480, HT29) | up-regulated | expression | Long?non-coding?RNA?HOTAIR is a powerful predictor of metastasis and poor prognosis and is associated with epithelial-mesenchymal transition in colon cancer. | 24840737 | LncRNADisease Lnc2Cancer |
| EL0758 | Lnc34a | colon cancer | N/A | colon cancer stem cells (CCSCs) | up-regulated | N/A | Lnc34a recruits Dnmt3a via PHB2 and HDAC1 to methylate and deacetylate the miR-34a promoter simultaneously | 27077950 | |
| EL0799 | lncRNA-ATB | colon cancer | qPCR etc. | colon cancer tissues | up-regulated | interaction | LncRNA-ATB was upregulated in colon cancer tissues compared with adjacent mucosa. LncRNA-ATB levels were also higher in metastatic cancer tissues. Among the three highly invasive colon cancer cell lines, lncRNA-ATB levels were relatively higher with concurrent low levels of E-cad compared with levels in the three low-invasive cell lines. LncRNA-ATB expression correlated with pN stage and AJCC stage. Striking differences were observed in overall survival and disease-free survival in cases with both high lncRNA-ATB expression and low E-cad expression. Reduction of lncRNA-ATB increased expression of epithelial markers E-cad, ZO-1, and decreased expression of mesenchymal markers ZEB1 and N-cadherin (N-cad), and significantly influenced colon cancer cell progression. Plasma lncRNA-ATB was upregulated in colon cancer patients one month after surgery. | 26487301 | Lnc2Cancer |
| EL0853 | MALAT1 | colon cancer | microarray, qPCR, knockdown etc. | blood, cell lines (SW480 and SW620) | up-regulated | regulation | The stimulation of colon cancer progression by TADC-derived CCL5 was associated with the up-regulation of non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1), which subsequently increased the expression of Snail. Blocking MALAT-1 significantly decreased the TADC-conditioned medium and CCL5-mediated migration and invasion by decreasing the enhancement of Snail, suggesting that the MALAT-1/Snail pathway plays a critical role in TADC-mediated cancer progression | 25546229 | Lnc2Cancer |
| EL0853 | MALAT1 | colon cancer | N/A | N/A | N/A | regulation | Sequesters SR splicing factors to regulate alternative splicing. | 22996375 | LncRNADisease |
| EL0861 | MEG3 | colon cancer | qPCR, ISH etc. | colon cancer tissue | down-regulated | expression | MEG3 expression is lost. | 14602737 | LncRNADisease Lnc2Cancer |
| EL1019 | OGT | colon cancer | N/A | N/A | up-regulated | N/A | HINCUT-1 supports cell proliferation specifically under hypoxic conditions and may be critical for optimal O-GlcNAcylation of proteins when oxygen tension is limiting. | 24037088 | |
| EL1083 | PRAS | colon cancer | qPCR etc. | cell lines (SNU-C4R, SNU-C5R etc.) | down-regulated | N/A | We selected three lncRNAs, snaR, BACE1AS, and PRAS, and we detected their expression by RT-qPCR using specific primer sets. SnaR and BACE1AS were significantly down-regulated in both resistant cell lines (SNU-C4R and SNU-C5R), whereas PRAS was down-regulated in SNU-C4R cells but not in SNU-C5R cells. Down-regulation of snaR decreased cell death after 5-FU treatment, which indicates that snaR loss decreases in vitro sensitivity to 5-FU. | 25078450 | Lnc2Cancer |
| EL1218 | SNAR-A1 | colon cancer | qPCR etc. | cell lines (SNU-C4R, SNU-C5R etc.) | down-regulated | interaction | We selected three lncRNAs, snaR, BACE1AS, and PRAS, and we detected their expression by RT-qPCR using specific primer sets. SnaR and BACE1AS were significantly down-regulated in both resistant cell lines (SNU-C4R and SNU-C5R), whereas PRAS was down-regulated in SNU-C4R cells but not in SNU-C5R cells. Down-regulation of snaR decreased cell death after 5-FU treatment, which indicates that snaR loss decreases in vitro sensitivity to 5-FU. | 25078450 | Lnc2Cancer |
| EL1402 | TUSC7 | colon cancer | deletion analysis, reciprocal repression, quantitative PCR arrays and in situ hybridization of tissue microarrays | N/A | down-regulated | N/A | a tumor suppressor unit in osteosarcoma and to suppress tumor cell growth. ,loc285194 is a p53 transcription target; ectopic expression of loc285194 inhibits tumor cell growth both in vitro and in vivo..loc285194 is a p53-regulated tumor suppressor, which acts in part through repression of miR-211. | 23558749 | |