LncRNA Information
ID EL0327 Name DACOR1 Aliases LP2570; TCONS_00023265
Species Homo sapiens Chromosome 15 Start site N/A
End site N/A Chain N/A Exon NO. N/A
Assembly N/A Class N/A NCBI accession N/A
Ensembl N/A Sequence N/A


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
colon cancer RNA-seq, qPCR, ChIRP-seq, Western blot, RIP etc. colon cancer tissue, cell line (HCT116) down-regulated interaction DACOR1 shows high, tissue-specific expression in the normal colon but was repressed in a panel of colon tumors and patient-derived colon cancer cell lines. Induction of DACOR1 in colon cancer cell lines significantly reduced their ability to form colonies in vitro, suggesting a growth suppressor function. Induction of DACOR1 led to the activation of tumor-suppressor pathways and attenuation of cancer-associated metabolic pathways. 26307088 Lnc2Cancer
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
Cystathionine β-synthase RNA-Protein regulation DACOR1 induction resulted in down-regulation of Cystathionine β-synthase, which is known to lead to increased levels of S-adenosyl methionine-the key methyl donor for DNA methylation. 26307088