| Disease |
| Disease |
Method |
Sample |
Expression pattern |
Dysfunction type |
Description |
PMID |
Source |
| osteosarcoma |
Cell counting kit 8 (CCK-8) assay, western blot |
osteosarcoma tissues |
down-regulated |
interaction |
Cell counting kit 8 (CCK-8) assay revealed that after silence of TUSC7, cell proliferation ability increased and the colony formation ability also increased. After silence of TUSC7, the proapoptotic Bcl2 expression was downregulated. Compared with negative control group, silence of TUSC7 significantly promoted tumor growth in vivo. Thus, we demonstrated that TUSC7 could be a potential tumor suppressor in osteosarcoma. |
26781978 |
|
| osteosarcoma |
deletion analysis, reciprocal repression, quantitative PCR arrays and in situ hybridization of tissue microarrays |
N/A |
down-regulated |
N/A |
a tumor suppressor unit in osteosarcoma and to suppress tumor cell growth. ,loc285194 is a p53 transcription target; ectopic expression of loc285194 inhibits tumor cell growth both in vitro and in vivo..loc285194 is a p53-regulated tumor suppressor, which acts in part through repression of miR-211. |
23558749 |
|
| colon cancer |
deletion analysis, reciprocal repression, quantitative PCR arrays and in situ hybridization of tissue microarrays |
N/A |
down-regulated |
N/A |
a tumor suppressor unit in osteosarcoma and to suppress tumor cell growth. ,loc285194 is a p53 transcription target; ectopic expression of loc285194 inhibits tumor cell growth both in vitro and in vivo..loc285194 is a p53-regulated tumor suppressor, which acts in part through repression of miR-211. |
23558749 |
|
| osteosarcoma |
microarray, qPCR, FISH etc. |
osteosarcoma tissue, cell lines (U2OS, SAOS-2, HOS etc.) |
down-regulated |
mutation |
These CNAs (copy number alterations) in osteosarcoma often involve the noncoding RNAs LOC285194 and BC040587. |
20048075 |
LncRNADisease Lnc2Cancer
|
| gastric cancer |
microarray, qPCR, knockdown etc. |
gastric cancer tissue |
down-regulated |
N/A |
The results indicated that TUSC7 was downregulated in GC samples and was an independent prognostic indicator of disease-free survival (DFS) and disease-specific survival (DSS) in GC patients.The results indicated that TUSC7 is a p53-regulated tumour suppressor that acts in part by repressing miR-23b and that TUSC7 may be a key regulatory hub in GC. |
25765901 |
LncRNADisease Lnc2Cancer
|
| hepatocelluar carcinoma |
N/A |
hepatocellular carcinoma |
down-regulated |
N/A |
inhibited cell metastasis, invasion, and epithelial-to-mesenchymal |
27002617 |
|
| colorectal cancer |
qPCR etc. |
CRC tissue, cell lines (CaCO-2, HCT8, LoVo, CCC-HIE-2 etc.) |
down-regulated |
N/A |
The relative expression levels of LOC285194 was significantly lower in tumor tissues (p<0.001) and colorectal cancer cell lines compared with adjacent normal tissues and normal intestinal mucous cell line. In addition, low expression of LOC285194 was correlated with larger tumor size, higher tumor stage (p=0.034), and more distant metastasis (p=0.046). Our data indicate that LOC285194 might be a novel prognostic indicator in colorectal cancer and may be a potential target for diagnosis and gene therapy. |
23680400 |
Lnc2Cancer
|
| esophageal squamous cell carcinoma |
qPCR, knockdown etc |
ESCC tissue, cell lines (KYSE30, KYSE 70, KYSE 150, KYSE510, Eca109) |
down-regulated |
N/A |
LOC285194 expression was significantly down-regulated in ESCC tumor tissues when compared with the adjacent normal tissues. Low expression of LOC285194 was associated with larger tumor size, advanced TNM stage, more lymph node metastases and distant metastases. |
25169763 |
LncRNADisease Lnc2Cancer
|
| |