INTERACTION |
ID |
lncRNA Name |
Interaction target |
Level of interaction |
Type of interaction |
Description |
PMID |
Source |
EL1399 |
TUG1 |
IgG |
RNA-Protein |
binding |
binding with IgG shown by RIP-Chip data. |
19571010 |
LncRNADisease
|
EL1399 |
TUG1 |
PRC2 |
RNA-Protein |
binding |
binding with PRC2 shown by RIP-Chip data. |
19571010 |
LncRNADisease
|
EL1399 |
TUG1 |
p53 |
DNA-TF |
regulation |
TUG1 is induced by p53, binds to PRC2, and has a role in repressing specific genes involved in cell-cycle regulation. |
19571010 |
LncRNADisease
|
EL1399 |
TUG1 |
PRC2 |
RNA-Protein |
binding |
TUG1 is induced by p53, binds to PRC2, and has a role in repressing specific genes involved in cell-cycle regulation. |
19571010 |
LncRNADisease
|
EL1399 |
TUG1 |
PRC2 |
RNA-Protein |
binding |
Required for the proper formation of photoreceptors in the developing retina. Tug1 associates with PRC2 and represses a number of cell cycle genes. |
21256239 |
LncRNADisease
|
EL1399 |
TUG1 |
Pc2 |
DNA-Protein |
regulation |
methylation/demethylation of Polycomb 2 protein (Pc2) controls relocation of growth-control genes between Polycomb bodies (PcGs) and interchromatin granules (ICGs) in response to growth signals. This movement is the consequence of binding of methylated and unmethylated Pc2 to the ncRNAs TUG1 and MALAT1/NEAT2. |
22078878 |
LncRNADisease
|
EL1399 |
TUG1 |
polycomb repressive complex 2 (PRC2) |
RNA-Protein |
binding |
binding to polycomb repressive complex 2 (PRC2), |
25366138 |
|
EL1399 |
TUG1 |
miR-145 |
RNA-RNA |
regulation |
TUG1 decreased the expression of miR-145 and there was a reciprocal repression between TUG1 and miR-145 in an Argonaute2-dependent manner. |
26318860 |
|
EL1399 |
TUG1 |
PRC2 |
RNA-Protein |
binding |
TUG1 could epigeneticly repress Kruppel-like factor 2 (KLF2) transcription in HCC cells by binding with PRC2 and recruiting it to KLF2 promoter region. |
26336870 |
|
EL1399 |
TUG1 |
Kruppel-like factor 2 (KLF2) |
RNA-Protein |
regulation |
TUG1 could epigeneticly repress Kruppel-like factor 2 (KLF2) transcription in HCC cells by binding with PRC2 and recruiting it to KLF2 promoter region. |
26336870 |
|
EL1399 |
TUG1 |
Bcl-2 |
RNA-Protein |
regulation |
Taurine upregulated gene 1 promoted cell apoptosis of glioma cells by activating caspase-3 and -9-mediated intrinsic pathways and inhibiting Bcl-2-mediated anti-apoptotic pathways, acting as a tumor suppressor in human glioma. |
26748401 |
|
EL1399 |
TUG1 |
caspase-3 and -9 |
RNA-Protein |
regulation |
Taurine upregulated gene 1 promoted cell apoptosis of glioma cells by activating caspase-3 and -9-mediated intrinsic pathways and inhibiting Bcl-2-mediated anti-apoptotic pathways, acting as a tumor suppressor in human glioma. |
26748401 |
|
EL1399 |
TUG1 |
PTEN |
RNA-DNA |
regulation |
The tumour-suppressive function of two lncRNAs (TUG1 and CTB-89H12.4) and their regulation of PTEN expression in prostate cancer. |
26975529 |
|
EL1400 |
Tug1 |
PRC2 |
RNA-Protein |
binding |
Numerous lincRNAs are physically associated with PRC2. |
19571010 |
LncRNADisease
|
|