| Function (not disease relevant) |
| Methods |
Sample/condition |
Expression pattern |
Dysfunction type |
Description |
PMID |
Source |
| Northern blots and in situ hybridization, knockdown, Immunofluorescent staining and microarray analyses |
retina |
N/A |
expression |
Tug1 is necessary for the proper formation of photoreceptors in the developing rodent retina. |
15797018 |
|
| qRT-PCR, knockdown, MTT, TUNEL and Annexin V-FITC assays and western blot, GSIS, ELISA and immunochemistry |
mouse pancreatic β cell |
up-regulated |
expression |
Knockdown of lncRNA TUG1 expression resulted in an increased apoptosis ratio and decreased insulin secretion in β cells both in vitro and in vivo |
25871529 |
|
| RNA-seq, overexpression |
mouse hepatocytes and liver sinusoidal endothelial cells LSECs |
down-regulated |
expression |
Overexpression of TUG1 attenuated cold-induced apoptosis in mouse hepatocytes and liver sinusoidal endothelial cells LSECs, in part by blocking mitochondrial apoptosis and endoplasmic reticulum (ER) stress pathways. TUG1 attenuated apoptosis, inflammation, and oxidative stress in vivo in livers subjected to cold storage. Overexpression of TUG1 also improved hepatocyte function and prolonged hepatic graft survival rates in mice. These results suggest that the lncRNA TUG1 exerts a protective effect against cold-induced liver damage by inhibiting apoptosis in mice, and suggests a potential role for TUG1 as a target for the prevention of cold-induced liver damage in liver transplantation. |
26785829 |
|
| |