INTERACTION
ID	lncRNA Name	Interaction target	Level of interaction	Type of interaction	Description	PMID	Source
EL1365	Trp53cor1	p53	DNA-TF	regulation	lincRNA-p21 is induced by p53 in different cell systems. lincRNA-p21 as a repressor in the p53 pathway.lincRNA-p21 is a direct p53 transcriptional target in response to DNA damage.	20673990	LncRNADisease
EL1365	Trp53cor1	hnRNP-K	RNA-DNA	regulation	The depletion of lincRNA-p21 causes a significant reduction in the association of hnRNP-K at the promoter regions of genes that are normally repressed in a lincRNA-p21 and p53-dependent fashion.	20673990	LncRNADisease
EL1365	Trp53cor1	p53	DNA-TF	regulation	Induced by p53 and mediates p53 repression of many genes in association with hnRNP-k.	21256239	LncRNADisease
EL1365	Trp53cor1	hnRNP-k	RNA-Protein	binding	Induced by p53 and mediates p53 repression of many genes in association with hnRNP-k.	21256239	LncRNADisease
EL1365	Trp53cor1	hnRNP-K	RNA-Protein	binding	hnRNP-K interacted with a 50 domain of lincRNA-p21 that was necessary but not sufficient to induce apoptosis, suggesting that other regions of the RNA are required to recruit other factors or target the complex to chromatin or both.	21496640	LncRNADisease
EL1365	Trp53cor1	p53	RNA-DNA	regulation	lincRNA-p21 acts as a transcriptional repressor turning off multiple genes during the p53 response.	21496640	LncRNADisease
EL1365	Trp53cor1	p53	DNA-TF	regulation	p53 regulates lincRNA-p21 by directly inducing its expression, likely through direct binding to the lincRNA-p21 promoter, while reduction of large intergenic ncRNA (lincRNA)-p21 increases expression of numerous p53-repressed transcripts. lincRNA-p21 repressed p53-regulated genes through its binding to and modulation of heterogeneous nuclear ribonucleoprotein K (hnRNP-K) localization.	21925379	LncRNADisease
EL1365	Trp53cor1	hnRNP-K	RNA-Protein	binding	p53 regulates lincRNA-p21 by directly inducing its expression, likely through direct binding to the lincRNA-p21 promoter, while reduction of large intergenic ncRNA (lincRNA)-p21 increases expression of numerous p53-repressed transcripts. lincRNA-p21 repressed p53-regulated genes through its binding to and modulation of heterogeneous nuclear ribonucleoprotein K (hnRNP-K) localization.	21925379	LncRNADisease
EL1365	Trp53cor1	Cdkn1a	DNA-DNA	co-expression	LincRNA-p21 is an antisense transcript that is 15kb downstream from Cdkn1a locus and appears to be cotranscribed with the protein coding gene Cdkn1a at 8.0mg/kg furan.	23853263