| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL1365 | Name | Trp53cor1 | Aliases | Gm16197; OTTMUSG00000031656; linc-p21; lincRNA-p21 | |
| Species | Mus musculus | Chromosome | 17 | Start site | 29057474 | |
| End site | 29078961 | Chain | minus | Exon NO. | 2 | |
| Assembly | Ensembl Release 89 | Class | lincRNA | NCBI accession | NR_036469 | |
| Ensembl | ENSMUSG00000085912 | Sequence | ||||
| Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
| carcinogen furan | microarray analysis, quantitative RT-PCR | livers of female B6C3F1 mice exposed to the carcinogen furan at 0.0, 1.0, and 2.0mg/kg (noncarcinogenic doses) and at 4.0 and 8.0mg/kg (carcinogenic doses) for 3 weeks | up-regulated | expression | LincRNA-p21 is an antisense transcript that is 15kb downstream from Cdkn1a locus and appears to be cotranscribed with the protein coding gene Cdkn1a at 8.0mg/kg furan. | 23853263 | |||
| tumor | N/A | N/A | N/A | regulation | Global gene repression in the p53 transcriptional response by binding hnRNP-K, inducing cellular apoptosis. | 22996375 | LncRNADisease | ||
| cancer | N/A | N/A | N/A | expression | lincRNA-p21 (named for its vicinity to the CDKN1A/p21 locus) is upregulated by p53 upon DNA damage and implicated in downstream repressive effects of the p53 pathway, particularly on genes regulating apoptosis, possibly by directing the recruitment of hnRNP-K to its genomic targets. | 23463798 | LncRNADisease | ||
| tumor | N/A | N/A | N/A | regulation | Thus, similar to its activator p53, lincRNA-p21 may play an important role in tumour suppression by operating as a transcriptional repressor. | 23660942 | LncRNADisease | ||
| tumor | N/A | N/A | N/A | regulation | Global gene regulation p53 repression via hnRNP-K; inducing cellular apoptosis | 24499465 | LncRNADisease | ||
| tumor | N/A | N/A | N/A | regulation | ANRIL, GAS5 and lincRNA-p23 are involved in the escape of growth suppression by regulating tumor suppressor genes (ANRIL) or apoptosis regulators. | 24667321 | LncRNADisease | ||
| cancer | N/A | N/A | N/A | regulation | They identified lincRNA-p21 as a direct p53 target. Furthermore, they found that lincRNA-p21 is critical in regulating many of the genes that are repressed in response to p53 activity and they found that lincRNA-p21 associates with hnRNP-K. The lincRNA-p21/hnRNP-K interaction was found to be necessary for hnRNP-K genomic localization at sites of gene repression. | 24829860 | LncRNADisease | ||
| colorectal cancer | qPCR etc. | CRC tissue, cell lines (HCT-116 (p53t/t), HCT-116(p53-/-) etc.) | down-regulated | expression | One of them, lincRNA-p21, was regulated by p53 and contributed to apoptosis in mouse embryonic fibroblasts. | 24012455 | LncRNADisease Lnc2Cancer | ||
| Function (not disease relevant) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Methods | Sample/condition | Expression pattern | Dysfunction type | Description | PMID | Source | |||
| N/A | N/A | N/A | expression | Biogenesis, metabolism, and functions of lncRNAs are otherwise interconnected with known pathogenic mechanisms | 23791884 | LncRNADisease | |||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| p53 | DNA-TF | regulation | lincRNA-p21 is induced by p53 in different cell systems. lincRNA-p21 as a repressor in the p53 pathway.lincRNA-p21 is a direct p53 transcriptional target in response to DNA damage. | 20673990 | LncRNADisease | ||||
| hnRNP-K | RNA-DNA | regulation | The depletion of lincRNA-p21 causes a significant reduction in the association of hnRNP-K at the promoter regions of genes that are normally repressed in a lincRNA-p21 and p53-dependent fashion. | 20673990 | LncRNADisease | ||||
| p53 | DNA-TF | regulation | Induced by p53 and mediates p53 repression of many genes in association with hnRNP-k. | 21256239 | LncRNADisease | ||||
| hnRNP-k | RNA-Protein | binding | Induced by p53 and mediates p53 repression of many genes in association with hnRNP-k. | 21256239 | LncRNADisease | ||||
| hnRNP-K | RNA-Protein | binding | hnRNP-K interacted with a 50 domain of lincRNA-p21 that was necessary but not sufficient to induce apoptosis, suggesting that other regions of the RNA are required to recruit other factors or target the complex to chromatin or both. | 21496640 | LncRNADisease | ||||
| p53 | RNA-DNA | regulation | lincRNA-p21 acts as a transcriptional repressor turning off multiple genes during the p53 response. | 21496640 | LncRNADisease | ||||
| p53 | DNA-TF | regulation | p53 regulates lincRNA-p21 by directly inducing its expression, likely through direct binding to the lincRNA-p21 promoter, while reduction of large intergenic ncRNA (lincRNA)-p21 increases expression of numerous p53-repressed transcripts. lincRNA-p21 repressed p53-regulated genes through its binding to and modulation of heterogeneous nuclear ribonucleoprotein K (hnRNP-K) localization. | 21925379 | LncRNADisease | ||||
| hnRNP-K | RNA-Protein | binding | p53 regulates lincRNA-p21 by directly inducing its expression, likely through direct binding to the lincRNA-p21 promoter, while reduction of large intergenic ncRNA (lincRNA)-p21 increases expression of numerous p53-repressed transcripts. lincRNA-p21 repressed p53-regulated genes through its binding to and modulation of heterogeneous nuclear ribonucleoprotein K (hnRNP-K) localization. | 21925379 | LncRNADisease | ||||
| Cdkn1a | DNA-DNA | co-expression | LincRNA-p21 is an antisense transcript that is 15kb downstream from Cdkn1a locus and appears to be cotranscribed with the protein coding gene Cdkn1a at 8.0mg/kg furan. | 23853263 | |||||