INTERACTION |
ID |
lncRNA Name |
Interaction target |
Level of interaction |
Type of interaction |
Description |
PMID |
Source |
EL0747 |
LINC-ROR |
Nanog |
DNA-TF |
regulation |
lincRNA-RoR, was shown to be directly targeted by the key pluripotency factors Oct4, Sox2, and Nanog through colocalization of the three factors close its promoter region. |
21925379 |
LncRNADisease
|
EL0747 |
LINC-ROR |
41186 |
DNA-TF |
regulation |
lincRNA-RoR, was shown to be directly targeted by the key pluripotency factors Oct4, Sox2, and Nanog through colocalization of the three factors close its promoter region. |
21925379 |
LncRNADisease
|
EL0747 |
LINC-ROR |
Sox2 |
DNA-TF |
regulation |
lincRNA-RoR, was shown to be directly targeted by the key pluripotency factors Oct4, Sox2, and Nanog through colocalization of the three factors close its promoter region. |
21925379 |
LncRNADisease
|
EL0747 |
LINC-ROR |
p70S6K1 (RPS6KB1), PDK1 and HIF-1α |
RNA-Protein |
regulation |
siRNA to linc-RoR decreased phosphorylation of p70S6K1 (RPS6KB1), PDK1 and HIF-1α protein expression and increased expression of the linc-RoR target microRNA-145 (miR-145). |
24463816 |
|
EL0747 |
LINC-ROR |
miR-145 |
RNA-RNA |
regulation |
siRNA to linc-RoR decreased phosphorylation of p70S6K1 (RPS6KB1), PDK1 and HIF-1α protein expression and increased expression of the linc-RoR target microRNA-145 (miR-145). |
24463816 |
|
EL0747 |
LINC-ROR |
NRF2 |
RNA-TF |
binding |
NRF2 binds to two specific NRF2 response elements flanking the ROR promoter and that these two NRF2 response elements are equally important to suppress ROR transcription. In addition, we identified associated H3K27me3 chromatin modification and EZH2 binding at the ROR promoter that was dependent on NRF2 binding. |
25231996 |
|
EL0747 |
LINC-ROR |
TESC |
RNA-DNA |
regulation |
lncRNA ROR occupies and activates the TESC promoter by repelling the histone G9A methyltransferase and promoting the release of histone H3K9 methylation. |
26169368 |
|
EL0747 |
LINC-ROR |
miR-145 |
RNA-RNA |
regulation |
ROR may act as a ceRNA, effectively becoming a sink for miR-145, thereby activating the derepression of core transcription factors Nanog. |
26636540 |
|
|