LncRNA Information
ID EL0747 Name LINC-ROR Aliases ROR; lincRNA-RoR
Species Homo sapiens Chromosome 18 Start site 57054559
End site 57072119 Chain minus Exon NO. 4
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_048536
Ensembl ENSG00000258609 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
triple-negative breast cancer microarray, qPCR, Western blot etc. breast cancer tissue, cell lines (HEK293T, MCF-7, HS578T, MDA-MB-231) up-regulated N/A LincRNA-RoR is upregulated in TNBC and in metastatic disease and knockdown restores miR-145 expression.The lincRNA-RoR/miR-145/ARF6 pathway is critical to TNBC metastasis and could serve as biomarkers or therapeutic targets for improving survival. 25253741 LncRNADisease Lnc2Cancer
hepatocelluar carcinoma qPCR, Luciferase reporter assays, knockdown etc. cell lines (HepG2, PLC-PRF5) up-regulated N/A lincRNA-ROR (linc-ROR), a stress-responsive lncRNA was highly expressed in HCC cells and enriched within extracellular vesicles derived from tumor cells. Incubation with HCC-derived extracellular vesicles increased linc-ROR expression and reduced chemotherapy-induced cell death in recipient cells. Sorafenib increased linc-ROR expression in both tumor cells and extracellular vesicles, whereas siRNA to linc-ROR increased chemotherapy-induced apoptosis and cytotoxicity. 24918061 Lnc2Cancer
breast cancer qPCR, vivo knockdown, PIR etc. breast cancer tissue up-regulated N/A linc-ROR was upregulated in breast tumor and ectopic overexpression of linc-ROR in immortalized human mammary epithelial cells induced an epithelial-to-mesenchymal transition (EMT) program. Moreover,linc-ROR enhanced breast cancer cell migration and invasion. Linc-ROR was associated with miRNPs and functioned as a competing endogenous RNA to mi-205. linc-ROR functions as an important regulator of EMT and can promote breast cancer progression and metastasis through regulation of miRNAs. 24922071 Lnc2Cancer
colorectal cancer qPCR, Western blot, knockdown etc. cell lines (HT29, HRT-18) up-regulated interaction we found that the expression of ROR was significantly increased in a series of tumor cells, whereas all of the negative controls remained weakly expressed. 26169368 Lnc2Cancer
malignant melanoma qPCR, Western blot, knockdown etc. cell lines (OM431, MUM2B) up-regulated expression we found that the expression of ROR was significantly increased in a series of tumor cells, whereas all of the negative controls remained weakly expressed. 26169368 Lnc2Cancer
gastric cancer qPCR, Western blot, knockdown etc. cell line (AGS) up-regulated expression we found that the expression of ROR was significantly increased in a series of tumor cells, whereas all of the negative controls remained weakly expressed. 26169368 Lnc2Cancer
pancreatic cancer qRT-PCR, RNA interference approaches, luciferase assays and RNA binding protein immunoprecipitation, immunohistochemistry assay 61 paired cancerous and noncancerous tissue samples, pancreatic cancer stem cells (PCSCs) up-regulated expression Knockdown of ROR by RNA interference in PCSCs inhibited proliferation, induced apoptosis and decreased migration. Moreover, ROR silencing resulted in significantly decreased tumourigenicity of PCSCs in nude mice than controls. 26636540
liver cancer RT-PCR, knockdown N/A up-regulated interaction linc-RoR is a hypoxia-responsive lncRNA that is functionally linked to hypoxia signaling in HCC through a miR-145-HIF-1α signaling module. 24463816
 


Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
knockdown wild-type and NRF2 knockdown mammary stem cells N/A expression NRF2 knockdown or ROR overexpression leads to increased stem cell self-renewal in mammary stem cells 25231996
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
Nanog DNA-TF regulation lincRNA-RoR, was shown to be directly targeted by the key pluripotency factors Oct4, Sox2, and Nanog through colocalization of the three factors close its promoter region. 21925379 LncRNADisease
41186 DNA-TF regulation lincRNA-RoR, was shown to be directly targeted by the key pluripotency factors Oct4, Sox2, and Nanog through colocalization of the three factors close its promoter region. 21925379 LncRNADisease
Sox2 DNA-TF regulation lincRNA-RoR, was shown to be directly targeted by the key pluripotency factors Oct4, Sox2, and Nanog through colocalization of the three factors close its promoter region. 21925379 LncRNADisease
p70S6K1 (RPS6KB1), PDK1 and HIF-1α RNA-Protein regulation siRNA to linc-RoR decreased phosphorylation of p70S6K1 (RPS6KB1), PDK1 and HIF-1α protein expression and increased expression of the linc-RoR target microRNA-145 (miR-145). 24463816
miR-145 RNA-RNA regulation siRNA to linc-RoR decreased phosphorylation of p70S6K1 (RPS6KB1), PDK1 and HIF-1α protein expression and increased expression of the linc-RoR target microRNA-145 (miR-145). 24463816
NRF2 RNA-TF binding NRF2 binds to two specific NRF2 response elements flanking the ROR promoter and that these two NRF2 response elements are equally important to suppress ROR transcription. In addition, we identified associated H3K27me3 chromatin modification and EZH2 binding at the ROR promoter that was dependent on NRF2 binding. 25231996
TESC RNA-DNA regulation lncRNA ROR occupies and activates the TESC promoter by repelling the histone G9A methyltransferase and promoting the release of histone H3K9 methylation. 26169368
miR-145 RNA-RNA regulation ROR may act as a ceRNA, effectively becoming a sink for miR-145, thereby activating the derepression of core transcription factors Nanog. 26636540