| INTERACTION | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| ID | lncRNA Name | Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||
| EL0514 | FTX | Xist | RNA-RNA | regulation | The Ftx mutation, however, results in widespread alteration of transcript levels within the X-inactivation center (Xic) and particularly important decreases in Xist RNA levels. | 21118898 | |||
| EL0514 | FTX | RIG-I | RNA-Protein | regulation | Ectopic expression of RIG-I abrogated the effects of lncRNA Ftx or miR-545 on HCC cells. LncRNA Ftx/miR-545-mediated downregulation of RIG-I led to increased Akt phosphorylation in vitro and in vivo. | 26992218 | |||
| EL0514 | FTX | miR-545 , RIG-I | RNA-RNA | co-expression | MiR-545 was positively correlated with lncRNA Ftx expression. | 26992218 | |||
| EL0514 | FTX | PI3K/Akt signaling | N/A | regulation | The novel pathway lncRNA Ftx/miR-545/RIG-I promotes HCC development by activating PI3K/Akt signaling. | 26992218 | |||
| EL0515 | Ftx | XIST | RNA-DNA | regulation | Ftx has both a global role in the adjustment of the transcription levels of several genes in the Xic and a positive effect on Xist expression that coincides with a role in preventing the methylation of the Xist promoter. | 21329697 | LncRNADisease | ||
| EL0515 | Ftx | XIST | RNA-RNA | co-expression | Ftx is upregulated specifically in female cells at the time of Xist upregulation and X inactivation. | 21496640 | LncRNADisease | ||