LncRNA Information
ID EL0514 Name FTX Aliases LINC00182; MIR374AHG; NCRNA00182
Species Homo sapiens Chromosome X Start site 73946555
End site 74293574 Chain minus Exon NO. 7
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_028379
Ensembl ENSG00000230590 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
hepatocelluar carcinoma HCC tissues and cells; clinical analysis HCC tissues and cells up-regulated N/A pathway lncRNA Ftx/miR-545/RIG-I promotes HCC development by activating PI3K/Akt signaling 26992218
hepatocelluar carcinoma N/A HBV-related HCC tissue up-regulated expression The overexpression of miR-545/374a cluster located in the Ftx lncRNA is partially responsible for a poor prognosis, and monitoring sera levels of miR-545/374a may be a useful diagnostic marker for HCC. 25299640
colorectal cancer qPCR, knockdown etc CRC and adjacent normal colorectal tissues, cell lines (HT-29, SW1116, SW480, COLO205) up-regulated expression Long non-coding RNA FTX was significantly upregulated in colorectal cancer tissues, and low long non-coding RNA FTX expression was significantly correlated with differentiation grade, lymph vascular invasion, and clinical stage. Patients with high long non-coding RNA FTX showed poorer overall survival than those with low long non-coding RNA FTX. Multivariate analyses indicated that status of long non-coding RNA FTX was an independent prognostic factor for patients. Functional analyses showed that upregulation of long non-coding RNA FTX significantly promoted growth, migration, invasion, and increased colony formation in colorectal cancer cells. 26629053 Lnc2Cancer
 


Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
N/A N/A Up-regulated interaction mutation cuasesalteration of transcript levels within the X-inactivation center and particularly important decreases in Xist RNA levels 21118898
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
Xist RNA-RNA regulation The Ftx mutation, however, results in widespread alteration of transcript levels within the X-inactivation center (Xic) and particularly important decreases in Xist RNA levels. 21118898
RIG-I RNA-Protein regulation Ectopic expression of RIG-I abrogated the effects of lncRNA Ftx or miR-545 on HCC cells. LncRNA Ftx/miR-545-mediated downregulation of RIG-I led to increased Akt phosphorylation in vitro and in vivo. 26992218
miR-545 , RIG-I RNA-RNA co-expression MiR-545 was positively correlated with lncRNA Ftx expression. 26992218
PI3K/Akt signaling N/A regulation The novel pathway lncRNA Ftx/miR-545/RIG-I promotes HCC development by activating PI3K/Akt signaling. 26992218