| INTERACTION | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| ID | lncRNA Name | Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||
| EL0289 | CDKN2B-AS1 | ARF | RNA-DNA | regulation | Binding to RNA contributes to CBX7 function and disruption of either interaction impacts the ability of CBX7 to repress the INK4b/ARF/INK4a locus and control senescence. | 20541999 | LncRNADisease | ||
| EL0289 | CDKN2B-AS1 | INK4a | RNA-DNA | regulation | Binding to RNA contributes to CBX7 function and disruption of either interaction impacts the ability of CBX7 to repress the INK4b/ARF/INK4a locus and control senescence. | 20541999 | LncRNADisease | ||
| EL0289 | CDKN2B-AS1 | INK4b | RNA-DNA | regulation | Binding to RNA contributes to CBX7 function and disruption of either interaction impacts the ability of CBX7 to repress the INK4b/ARF/INK4a locus and control senescence. | 20541999 | LncRNADisease | ||
| EL0289 | CDKN2B-AS1 | CBX7 | RNA-Protein | binding | Chromobox 7 (CBX7) within the polycomb repressive complex 1 (PRC1) binds to ANRIL. | 20541999 | LncRNADisease | ||
| EL0289 | CDKN2B-AS1 | CBX7 | RNA-Protein | binding | Here we report that chromobox 7 (CBX7) within the polycomb repressive complex 1 binds to ANRIL, and both CBX7 and ANRIL are found at elevated levels in prostate cancer tissues. | 20541999 | LncRNADisease | ||
| EL0289 | CDKN2B-AS1 | PRC1 | RNA-Protein | binding | Recruits Polycomb Repressor Complex 1 (PRC1) to epigenetically silence INK4b/ARF/INK4a tumour suppressor locus. | 20541999 | LncRNADisease | ||
| EL0289 | CDKN2B-AS1 | E2F1 | DNA-TF | regulation | ANRIL is implicated in the regulation of nucleus and potential transcriptional target of E2F1. | 20664976 | LncRNADisease | ||
| EL0289 | CDKN2B-AS1 | CBX7 | RNA-Protein | binding | Chromobox 7 (CBX7) within the polycomb repressive complex 1 (PRC1) has been shown to bind to ANRIL | 20956613 | LncRNADisease | ||
| EL0289 | CDKN2B-AS1 | p15 | RNA-DNA | regulation | RNA immunoprecipitation demonstrates that ANRIL binds to SUZ12 in vivo. Collectively, these results suggest a model in which ANRIL binds to and recruits PRC2 to repress the expression of p15(INK4B) locus. | 21151178 | LncRNADisease | ||
| EL0289 | CDKN2B-AS1 | PRC2 | RNA-Protein | binding | RNA immunoprecipitation demonstrates that ANRIL binds to SUZ12 in vivo. Collectively, these results suggest a model in which ANRIL binds to and recruits PRC2 to repress the expression of p15(INK4B) locus. | 21151178 | LncRNADisease | ||
| EL0289 | CDKN2B-AS1 | SUZ12 | RNA-Protein | binding | RNA immunoprecipitation demonstrates that ANRIL binds to SUZ12 in vivo. Collectively, these results suggest a model in which ANRIL binds to and recruits PRC2 to repress the expression of p15(INK4B) locus. | 21151178 | LncRNADisease | ||
| EL0289 | CDKN2B-AS1 | PRC1 | RNA-Protein | binding | Although lncRNA-mediated regulation of INK4b-ARF-INK4a gene is not restricted to ANRIL, both polycomb repressive complex-1 (PRC1) and -2 (PRC2) interact with ANRIL to form heterochromatin surrounding the INK4b-ARF-INK4a locus, leading to its repression. | 21828241 | LncRNADisease | ||
| EL0289 | CDKN2B-AS1 | PRC2 | RNA-Protein | binding | Although lncRNA-mediated regulation of INK4b-ARF-INK4a gene is not restricted to ANRIL, both polycomb repressive complex-1 (PRC1) and -2 (PRC2) interact with ANRIL to form heterochromatin surrounding the INK4b-ARF-INK4a locus, leading to its repression. | 21828241 | LncRNADisease | ||
| EL0289 | CDKN2B-AS1 | PRC1 | RNA-Protein | binding | Both polycomb repressive complex-1 (PRC1) and -2 (PRC2) interact with ANRIL to form heterochromatin surrounding the INK4b-ARF-INK4a locus, leading to its repression. | 21828241 | LncRNADisease | ||
| EL0289 | CDKN2B-AS1 | PRC2 | RNA-Protein | binding | Both polycomb repressive complex-1 (PRC1) and -2 (PRC2) interact with ANRIL to form heterochromatin surrounding the INK4b-ARF-INK4a locus, leading to its repression. | 21828241 | LncRNADisease | ||
| EL0289 | CDKN2B-AS1 | PcG | RNA-Protein | binding | PcG repress the expression of INK4b-ARF-INK4a locus by directly binding to the long noncoding RNA (lncRNA) transcript antisense noncoding RNA in the INK4 locus (ANRIL). | 21828241 | LncRNADisease | ||
| EL0289 | CDKN2B-AS1 | PcG | RNA-Protein | binding | The important role of PcG in mediating repression of the INK4b-ARF-INK4a locus, by directly binding to the long noncoding RNA (lncRNA) transcript antisense noncoding RNA in the INK4 locus (ANRIL), was recently shown. | 21828241 | LncRNADisease | ||
| EL0289 | CDKN2B-AS1 | PRC1 | RNA-Protein | binding | ANRIL (i.e.antisense ncRNA in INK4 locus) has also been linked to transcriptional repression via interaction with both PRC1 and PRC2. | 21831473 | LncRNADisease | ||
| EL0289 | CDKN2B-AS1 | PRC2 | RNA-Protein | binding | ANRIL (i.e.antisense ncRNA in INK4 locus) has also been linked to transcriptional repression via interaction with both PRC1 and PRC2. | 21831473 | LncRNADisease | ||
| EL0289 | CDKN2B-AS1 | CBX7 | RNA-Protein | binding | ANRIL was also found to coimmunoprecipitate with CBX7, which is component of the polycomb repressive complex 1 (PRC1). | 21874119 | LncRNADisease | ||
| EL0289 | CDKN2B-AS1 | Suz12 | RNA-Protein | binding | ANRIL was found to co-immunoprecipitate with Suz12, which is component of PRC2. | 21874119 | LncRNADisease | ||
| EL0289 | CDKN2B-AS1 | p15INK4B | RNA-RNA | co-expression | full-length ANRIL was shown to repress p15INK4B expression. Induction of p15INK4B and p16INK4A by oncogenic Ras was found to repress ANRIL expression. | 21874119 | LncRNADisease | ||
| EL0289 | CDKN2B-AS1 | p16INK4A | RNA-RNA | co-expression | induction of p15INK4B and p16INK4A by oncogenic Ras was found to repress ANRIL expression. | 21874119 | LncRNADisease | ||
| EL0289 | CDKN2B-AS1 | PRC1 | RNA-Protein | binding | Work over the past few years has demonstrated a direct interaction between ANRIL and components from both PRC1 and PRC2 complexes. Binding to ANRIL contributes to the functions of both PRC1 and PRC2 proteins, and disruption of either interaction impacts transcriptional repression of the target INK4b locus. | 21925379 | LncRNADisease | ||
| EL0289 | CDKN2B-AS1 | PRC2 | RNA-Protein | binding | Work over the past few years has demonstrated a direct interaction between ANRIL and components from both PRC1 and PRC2 complexes. Binding to ANRIL contributes to the functions of both PRC1 and PRC2 proteins, and disruption of either interaction impacts transcriptional repression of the target INK4b locus. | 21925379 | LncRNADisease | ||
| EL0289 | CDKN2B-AS1 | Cisplatin and paclitaxel | N/A | regulation | Cisplatin and paclitaxel have target function on significant lncRNAs in LSCC, which presents novel molecular targets to cure LSCC patients and also leads an orientation for developing new drugs. | 25257554 | |||
| EL0289 | CDKN2B-AS1 | KLF2 and P21 | RNA-DNA | regulation | we uncover that ANRIL could not repress p15 expression in PC9 cells, but through silencing of KLF2 and P21 transcription. | 25504755 | |||
| EL0289 | CDKN2B-AS1 | MET and MMP3 | RNA-DNA | regulation | we found that MET and MMP3 are key downstream genes of ANRIL involved in SOC cell migration/invasion. | 25845387 | |||
| EL0289 | CDKN2B-AS1 | KLF2 | RNA-DNA | binding | We also found that ANRIL could epigenetically repress Kruppel-like factor 2 (KLF2) transcription in HCC cells by binding with PRC2 and recruiting it to the KLF2 promoter region. | 25966845 | |||
| EL0289 | CDKN2B-AS1 | p15 | RNA-DNA | regulation | Depletion of ANRIL increased p15 expression, with no impact on p16 or ARF (alternative reading frame) expression, and caused cell-cycle arrest at the G2/M phase, leading to inhibition of proliferation of H1299 and HeLa cells. | 26408699 | |||
| EL0289 | CDKN2B-AS1 | Bcl-2, Bax, cytoplasmic cytochrome c and Smac and cleaved caspase-9, caspase-3 and PARP | RNA-Protein | regulation | Knockdown of ANRIL repressed cell proliferation and increased cell apoptosis, along with decreased expression of Bcl-2 and increased expressions of Bax, cytoplasmic cytochrome c and Smac and cleaved caspase-9, caspase-3 and PARP. | 26449463 | |||
| EL0289 | CDKN2B-AS1 | p15/CDKN2Bp16/CDKN2A-p14/ARF | RNA-Protein | regulation | These data demonstrate a complex pattern of interactions between lncRNA ANRIL, several miRNAs, PRC2/PRC1 subunits, and p15/CDKN2B-p16/CDKN2A-p14/ARF locus and suggest that their expression should be considered together to evaluate antitumoral drugs, in particular the BET bromodomain inhibitors. | 27102007 | |||
| EL0289 | CDKN2B-AS1 | MDR1 and MRP1 | RNA-Protein | co-expression | The expression of ANRIL positively correlated with the expression of MDR1 and MRP1, resprectively | 27121324 | |||