INTERACTION |
ID |
lncRNA Name |
Interaction target |
Level of interaction |
Type of interaction |
Description |
PMID |
Source |
EL0044 |
Airn |
G9a |
RNA-Protein |
binding |
Recruits G9a histone methyltransferase to epigenetically silence some target genes. |
11845212 |
LncRNADisease
|
EL0044 |
Airn |
Igf2r |
RNA-DNA |
regulation |
Controls Igf2r imprinting cluster in mouse |
16874305 |
LncRNADisease
|
EL0044 |
Airn |
Ig2fr |
RNA-RNA |
co-expression |
Neuron-specific lack of Airn expression results in neuronspecific lack of silencing at the Ig2fr locus. |
18184812 |
LncRNADisease
|
EL0044 |
Airn |
Slc22a3 |
RNA-DNA |
regulation |
The Airn noncoding RNA epigenetically silences transcription by targeting G9a to chromatin. Air accumulates at the Slc22a3 promoter in correlation with localized H3K9 methylation and transcriptional repression. |
18988810 |
LncRNADisease
|
EL0044 |
Airn |
G9a |
RNA-Protein |
binding |
The Airn noncoding RNA epigenetically silences transcription by targeting G9a to chromatin. Airn accumulates at the Slc22a3 promoter in correlation with localized H3K9 methylation and transcriptional repression. |
18988810 |
LncRNADisease
|
EL0044 |
Airn |
Slc22a3 promoter |
RNA-DNA |
regulation |
Air interacts with the Slc22a3 promoter chromatin and the H3K9 histone methyltransferase G9a in placenta. |
18988810 |
|
EL0044 |
Airn |
G9a |
RNA-Protein |
binding |
The Airn RNA also binds to G9a and appears to target this enzyme to a silenced gene in the cluster. |
19239885 |
LncRNADisease
|
EL0044 |
Airn |
G9a |
RNA-Protein |
binding |
The antisense transcript AIRN that is associated with the chromatin-modifying complex G9a. |
19571010 |
LncRNADisease
|
EL0044 |
Airn |
Igf2r |
DNA-DNA |
regulation |
Deletion of the Airn promoter on the paternal allele results in aberrant activation of paternal Igf2r, Slc22a2, and Slc22a3 genes in cis. |
19727951 |
LncRNADisease
|
EL0044 |
Airn |
Slc22a2 |
DNA-DNA |
regulation |
Deletion of the Airn promoter on the paternal allele results in aberrant activation of paternal Igf2r, Slc22a2, and Slc22a3 genes in cis. |
19727951 |
LncRNADisease
|
EL0044 |
Airn |
Slc22a3 |
DNA-DNA |
regulation |
Deletion of the Airn promoter on the paternal allele results in aberrant activation of paternal Igf2r, Slc22a2, and Slc22a3 genes in cis. |
19727951 |
LncRNADisease
|
EL0044 |
Airn |
Igf2r |
RNA-RNA |
co-expression |
Insertion of a polyadenylation cassette leading to truncation of the Air transcript resulted in the derepression of imprinted genes in the locus, which is suggestive of a direct role for long ncRNAs in imprinting of insulin-like growth factor 2 receptor (Igf2r). |
21831473 |
LncRNADisease
|
EL0044 |
Airn |
G9a |
RNA-Protein |
binding |
The Airn lncRNA was found to coat its target genes but instead recruits the G9a histone methyltransferase rather than the subunits of PRC2 |
21874119 |
LncRNADisease
|
EL0044 |
Airn |
G9a |
RNA-Protein |
binding |
Airn transcription unit recruits G9a to its target promoter to bring about gene silencing |
21925379 |
LncRNADisease
|
EL0044 |
Airn |
Igf2r |
DNA-DNA |
regulation |
A CpG island (CGI) lies at the 5' end of the Airn macro non-protein-coding (nc) RNA that represses the flanking Igf2r promoter in cis on paternally inherited chromosomes. |
22396659 |
LncRNADisease
|
|