| INTERACTION | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| ID | lncRNA Name | Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||
| EL0044 | Airn | G9a | RNA-Protein | binding | Recruits G9a histone methyltransferase to epigenetically silence some target genes. | 11845212 | LncRNADisease | ||
| EL0044 | Airn | Igf2r | RNA-DNA | regulation | Controls Igf2r imprinting cluster in mouse | 16874305 | LncRNADisease | ||
| EL0044 | Airn | Ig2fr | RNA-RNA | co-expression | Neuron-specific lack of Airn expression results in neuronspecific lack of silencing at the Ig2fr locus. | 18184812 | LncRNADisease | ||
| EL0044 | Airn | Slc22a3 | RNA-DNA | regulation | The Airn noncoding RNA epigenetically silences transcription by targeting G9a to chromatin. Air accumulates at the Slc22a3 promoter in correlation with localized H3K9 methylation and transcriptional repression. | 18988810 | LncRNADisease | ||
| EL0044 | Airn | G9a | RNA-Protein | binding | The Airn noncoding RNA epigenetically silences transcription by targeting G9a to chromatin. Airn accumulates at the Slc22a3 promoter in correlation with localized H3K9 methylation and transcriptional repression. | 18988810 | LncRNADisease | ||
| EL0044 | Airn | Slc22a3 promoter | RNA-DNA | regulation | Air interacts with the Slc22a3 promoter chromatin and the H3K9 histone methyltransferase G9a in placenta. | 18988810 | |||
| EL0044 | Airn | G9a | RNA-Protein | binding | The Airn RNA also binds to G9a and appears to target this enzyme to a silenced gene in the cluster. | 19239885 | LncRNADisease | ||
| EL0044 | Airn | G9a | RNA-Protein | binding | The antisense transcript AIRN that is associated with the chromatin-modifying complex G9a. | 19571010 | LncRNADisease | ||
| EL0044 | Airn | Igf2r | DNA-DNA | regulation | Deletion of the Airn promoter on the paternal allele results in aberrant activation of paternal Igf2r, Slc22a2, and Slc22a3 genes in cis. | 19727951 | LncRNADisease | ||
| EL0044 | Airn | Slc22a2 | DNA-DNA | regulation | Deletion of the Airn promoter on the paternal allele results in aberrant activation of paternal Igf2r, Slc22a2, and Slc22a3 genes in cis. | 19727951 | LncRNADisease | ||
| EL0044 | Airn | Slc22a3 | DNA-DNA | regulation | Deletion of the Airn promoter on the paternal allele results in aberrant activation of paternal Igf2r, Slc22a2, and Slc22a3 genes in cis. | 19727951 | LncRNADisease | ||
| EL0044 | Airn | Igf2r | RNA-RNA | co-expression | Insertion of a polyadenylation cassette leading to truncation of the Air transcript resulted in the derepression of imprinted genes in the locus, which is suggestive of a direct role for long ncRNAs in imprinting of insulin-like growth factor 2 receptor (Igf2r). | 21831473 | LncRNADisease | ||
| EL0044 | Airn | G9a | RNA-Protein | binding | The Airn lncRNA was found to coat its target genes but instead recruits the G9a histone methyltransferase rather than the subunits of PRC2 | 21874119 | LncRNADisease | ||
| EL0044 | Airn | G9a | RNA-Protein | binding | Airn transcription unit recruits G9a to its target promoter to bring about gene silencing | 21925379 | LncRNADisease | ||
| EL0044 | Airn | Igf2r | DNA-DNA | regulation | A CpG island (CGI) lies at the 5' end of the Airn macro non-protein-coding (nc) RNA that represses the flanking Igf2r promoter in cis on paternally inherited chromosomes. | 22396659 | LncRNADisease | ||