LncRNA Information
ID EL0044 Name Airn Aliases 2810051F02Rik; 2810434M15Rik; AI256653; AI597500; AW049873; Air; B930018I07Rik; D17Ertd663e; IGF2RAS
Species Mus musculus Chromosome 17 Start site 12741311
End site 12860122 Chain plus Exon NO. 6
Assembly Ensembl Release 89 Class antisense NCBI accession NR_027773, NR_027772, NR_027784, NR_002853
Ensembl ENSMUSG00000078247 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
alcoholic liver disease N/A N/A N/A expression Up regulation in liver by DDC (Diethyl 1,4-dihydro-2,4,6,-trimethyl-3,5-pyridinedicarboxylate ). 19362547 LncRNADisease
chronic nonalcoholic liver disease N/A N/A N/A expression Up regulation in liver by DDC (Diethyl 1,4-dihydro-2,4,6,-trimethyl-3,5-pyridinedicarboxylate ). 19362547 LncRNADisease
hepatocelluar carcinoma N/A N/A N/A expression Up regulation in liver by DDC (Diethyl 1,4-dihydro-2,4,6,-trimethyl-3,5-pyridinedicarboxylate ). Furthermore, over expression of H19 and AIR was demonstrated in tumors formed in mice withdrawn for 9 months. 19362547 LncRNADisease
 


Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
N/A E6.5 epiblast N/A locus Here we show lineage- and temporal-specific regulation of DNA methylation and histone modifications at the Igf2r/Airn locus correlating with differential establishment of imprinted expression during gastrulation. After gastrulation commences, the locus becomes imprinted in the embryonic lineage with the lncRNA Airn expressed from the paternal allele and Igf2r restricted to maternal allele expression. 25918552
N/A mouse placenta up-regulated interaction Air accumulates at the Slc22a3 promoter in correlation with localized H3K9 methylation and transcriptional repression. Genetic ablation of G9a results in nonimprinted, biallelic transcription of Slc22a3. 18988810
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
G9a RNA-Protein binding Recruits G9a histone methyltransferase to epigenetically silence some target genes. 11845212 LncRNADisease
Igf2r RNA-DNA regulation Controls Igf2r imprinting cluster in mouse 16874305 LncRNADisease
Ig2fr RNA-RNA co-expression Neuron-specific lack of Airn expression results in neuronspecific lack of silencing at the Ig2fr locus. 18184812 LncRNADisease
Slc22a3 RNA-DNA regulation The Airn noncoding RNA epigenetically silences transcription by targeting G9a to chromatin. Air accumulates at the Slc22a3 promoter in correlation with localized H3K9 methylation and transcriptional repression. 18988810 LncRNADisease
G9a RNA-Protein binding The Airn noncoding RNA epigenetically silences transcription by targeting G9a to chromatin. Airn accumulates at the Slc22a3 promoter in correlation with localized H3K9 methylation and transcriptional repression. 18988810 LncRNADisease
Slc22a3 promoter RNA-DNA regulation Air interacts with the Slc22a3 promoter chromatin and the H3K9 histone methyltransferase G9a in placenta. 18988810
G9a RNA-Protein binding The Airn RNA also binds to G9a and appears to target this enzyme to a silenced gene in the cluster. 19239885 LncRNADisease
G9a RNA-Protein binding The antisense transcript AIRN that is associated with the chromatin-modifying complex G9a. 19571010 LncRNADisease
Igf2r DNA-DNA regulation Deletion of the Airn promoter on the paternal allele results in aberrant activation of paternal Igf2r, Slc22a2, and Slc22a3 genes in cis. 19727951 LncRNADisease
Slc22a2 DNA-DNA regulation Deletion of the Airn promoter on the paternal allele results in aberrant activation of paternal Igf2r, Slc22a2, and Slc22a3 genes in cis. 19727951 LncRNADisease
Slc22a3 DNA-DNA regulation Deletion of the Airn promoter on the paternal allele results in aberrant activation of paternal Igf2r, Slc22a2, and Slc22a3 genes in cis. 19727951 LncRNADisease
Igf2r RNA-RNA co-expression Insertion of a polyadenylation cassette leading to truncation of the Air transcript resulted in the derepression of imprinted genes in the locus, which is suggestive of a direct role for long ncRNAs in imprinting of insulin-like growth factor 2 receptor (Igf2r). 21831473 LncRNADisease
G9a RNA-Protein binding The Airn lncRNA was found to coat its target genes but instead recruits the G9a histone methyltransferase rather than the subunits of PRC2 21874119 LncRNADisease
G9a RNA-Protein binding Airn transcription unit recruits G9a to its target promoter to bring about gene silencing 21925379 LncRNADisease
Igf2r DNA-DNA regulation A CpG island (CGI) lies at the 5' end of the Airn macro non-protein-coding (nc) RNA that represses the flanking Igf2r promoter in cis on paternally inherited chromosomes. 22396659 LncRNADisease