| EL0289 |
CDKN2B-AS1 |
serous ovarian cancer |
qPCR, Western blot, knockdown etc. |
SOC tissue, cell lines (SK-OV-3, HO8910) |
up-regulated |
interaction |
We found that ANRIL levels were elevated in SOC tissues compared with normal controls and were highly correlated with advanced FIGO stage, high histological grade, lymph node metastasis, and poor prognosis. Functional studies suggest a critical role of ANRIL in the control of SOC cell migration/invasion at least in part through regulation of MET and MMP3. |
25845387 |
Lnc2Cancer
|
| EL0578 |
HOTAIR |
serous ovarian cancer |
qPCR, knockdown etc. |
cell lines (A2780, Hey, SKOV3, OVCA429, OVCA433, OVCAR3) |
up-regulated |
expression |
We found that HOTAIR levels were overexpressed in SOC tissues compared with normal controls and that HOTAIR overexpression was correlated with an advanced FIGO stage and a high histological grade. HOTAIR knockdown resulted in the induction of cell cycle arrest and apoptosis through certain cell cycle-related and apoptosis-related proteins. |
25796453 |
Lnc2Cancer
|