| Related LncRNAs | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| ID | lncRNA Name | Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source |
| EL0227 | BANCR | melanoma | microarray, RNA-seq, qPCR etc. | cell lines (293T, sk-mel-5, Colo-829 etc.) | up-regulated | N/A | BRAF-regulated lncRNA 1 (BANCR) was identified as a recurrently overexpressed, previously unannotated 693-bp transcript on chromosome 9 with a potential functional role in melanoma cell migration. | 22581800 | LncRNADisease Lnc2Cancer |
| EL0227 | BANCR | melanoma | N/A | N/A | N/A | regulation | This screen revealed a 693 bp novel lncRNA transcript, named BRAF-activated non-coding RNA (BANCR).Depletion of BANCR in melanoma cells resulted in profound migration defects, indicating a significant role of BANCR in regulation of melanoma cell motility. | 24115003 | LncRNADisease |
| EL0289 | CDKN2B-AS1 | melanoma | N/A | N/A | N/A | mutation | Association identified by GWAS. | 17440112 | LncRNADisease Lnc2Cancer |
| EL0289 | CDKN2B-AS1 | melanoma | N/A | N/A | N/A | locus | A genetic susceptibility locus. | 20956613 | LncRNADisease |
| EL0289 | CDKN2B-AS1 | melanoma | N/A | N/A | N/A | mutation | A large germline deletion (403231 bp) encompassing the INK4/ARF locus and the ANRIL lncRNA has been associated with hereditary cutaneous malignant melanoma (CMM) and neural system tumors (NST) syndrome. | 21550244 | LncRNADisease |
| EL0289 | CDKN2B-AS1 | melanoma | N/A | N/A | N/A | expression | Disruptions to the expression of ANRIL have accordingly been associated with the development of several cancer types, including neuroblastoma , acute lymphocytic leukaemia, melanoma and prostate | 22817756 | LncRNADisease |
| EL0289 | CDKN2B-AS1 | melanoma | qPCR etc. | melanoma tissue | differential expression | mutation | Risk SNPs (rs3217992, A>G;rs1063192, C>T) for coronary disease, stroke, diabetes, melanoma, and glioma were all associated with allelic expression of ANRIL. | 20386740 | LncRNADisease Lnc2Cancer |
| EL0526 | GAS5 | melanoma | N/A | N/A | N/A | mutation | Chromosomal translocations affecting the 1q25 locus containing the Gas5 gene have been detected in melanoma, B-cell lymphoma, and prostate and breast cancer. | 18836484 | LncRNADisease Lnc2Cancer |
| EL0526 | GAS5 | melanoma | quantitative real-time polymerase chain reaction | SK-Mel‑110 melanoma cell | down-regulated | N/A | Overexpressing lncRNA GAS5 inhibited the migration and invasion | 26846479 | |
| EL0556 | H19 | melanoma | N/A | N/A | N/A | expression | The study of 4 sensitive and 2 resistant cell lines allowed the identification of 4 genes (RCC1, IFI16, hox2 and h19) preferentially transcribed in sensitive ((IFN-alpha therapy) cells and 2 (SHB and PKC-zeta) preferentially expressed in resistant cells. | 11437411 | LncRNADisease |
| EL0556 | H19 | melanoma | N/A | N/A | N/A | expression | H19 RNA downregulation stimulated melanogenesis in melasma. | 19968822 | LncRNADisease |
| EL0556 | H19 | melanoma | N/A | N/A | N/A | mutation | Although the IGF2 and H19 genotypes/haplotypes were not significantly associated with melanoma, two of the most severe cases (very early onset or multiple melanomas) showed to be heterozygous for both genes. | 20483645 | LncRNADisease |
| EL0578 | HOTAIR | melanoma | qPCR, in vitro knockdown etc. | melanoma tissue, cell lines (A375 etc.) | up-regulated | N/A | Among the tested lncRNAs, HOTAIR was the most highly expressed in lymph node metastasis. The role of HOTAIR in melanoma cell motility and invasion was further evaluated by knocking down HOTAIR with siRNAs. Knockdown of HOTAIR resulted in the reduction of motility and invasion of human melanoma cell line A375, as assessed by wound healing assay and Matrigel-based invasion assay. siHOTAIR also suppressed the degradation of gelatin matrix, suggesting that HOTAIR promotes gelatinase activity. Together, our study shows thatHOTAIR is overexpressed in metastatic tissue, which is associated with the ability of HOTAIR to promote melanoma cell motility and invasion. | 23862139 | Lnc2Cancer |
| EL0646 | LINC00032 | melanoma | N/A | N/A | N/A | mutation | An analysis of genome-wide DNA copy number alterations in melanoma tumors revealed the loss of the C9orf14 locus, located proximal to CDKN2A, in approximately one-fourth of tumors. | 17099875 | LncRNADisease |
| EL0752 | Llme23 | melanoma | qPCR, Western bolt, Northern bolt, knockdown, RIP etc. | cell lines (MCF10A, HEK293, A2058, SKmel28, YU-SIT1, YUSAC etc.) | differential expression | N/A | The specific binding of Llme23 to both recombinant and native PSF protein was confirmed in vitro and in vivo. The expression of PSF-binding Llme23 is exclusively detected in human melanoma lines. Knocking down Llme23 remarkably suppressed the malignant property of YUSAC cells, accompanied by the repressed expression of proto-oncogene Rab23. These results may indicate that Llme23 can function as an oncogenic RNA and directly associate the PSF-binding lncRNA with human melanoma. | 23618401 | Lnc2Cancer |
| EL0853 | MALAT1 | melanoma | qPCR, knockdown etc. | melanoma tissue, cell line (A-375) | up-regulated | N/A | highly expressed,can promote the metastasis of melanoma. The expression levels of UCA1 and Malat-1 lncRNAs had the potential to be prognostic indicators in metastasis of melanomas. | 24892958 | Lnc2Cancer |
| EL1177 | SAMMSON | melanoma | exogenous SAMMSON ; SAMMSON knockdown | melanoma | N/A | N/A | exogenous SAMMSON increases the clonogenic potential | 27008969 | |
| EL1240 | SPRY4-IT1 | melanoma | knockdown, affinity purification, mass spectrometry | melanoma cells | up-regulated | expression | SPRY4-IT1 knockdown may induce apoptosis via lipin 2-mediated alterations in lipid metabolism leading to cellular lipotoxicity. | 25344859 | |
| EL1240 | SPRY4-IT1 | melanoma | N/A | N/A | N/A | expression | The lncRNA, SPRY4-IT1, which is up-regulated in human melanomas compared to melanocytes and keratinocytes, affects cell dynamics, including increased rate of wound closure upon ectopic expression. | 22492512 | LncRNADisease |
| EL1240 | SPRY4-IT1 | melanoma | N/A | N/A | N/A | expression | Another elegant study by Khaitan et al. utilized a non-coding RNA microarray approach to identify differentially regulated lncRNAs in melanoma cells and identified a 687 bp single exon lncRNA named SPRY4-IT1 which was highly up-regulated in melanoma patient samples and cell lines. | 24115003 | LncRNADisease |
| EL1240 | SPRY4-IT1 | melanoma | qPCR, knockdown, FISH etc. | melanoma tissue | up-regulated | N/A | The melanoma-upregulated long noncoding RNA SPRY4-IT1 modulates apoptosis and invasion. | 21558391 | LncRNADisease Lnc2Cancer |
| EL1240 | SPRY4-IT1 | melanoma | qRT-PCR, WB, knockdown | severe preeclamptic placenta, trophoblast cells HTR-8/SVneo | up-regulated | expression | SPRY4-IT1 knockdown enhanced the cell migration and proliferation, and reduced the response of cells to apoptosis. However, exogenous SPRY4-IT1 overexpression significantly decreased the cell migration and proliferation, while increased cell apoptosis. | 24223182 | |
| EL1431 | UCA1 | melanoma | qPCR, knockdown etc. | melanoma tissue, cell line (A-375) | up-regulated | N/A | highly expressed,can promote the metastasis of melanoma. The expression levels of UCA1 and Malat-1 lncRNAs had the potential to be prognostic indicators in metastasis of melanomas. | 24892958 | Lnc2Cancer |