| Related LncRNAs | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| ID | lncRNA Name | Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source |
| EL0022 | STAG3L2 | lung adenocarcinoma | microarray, qPCR etc. | lung adenocarcinoma tissue | up-regulated | expression | We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. | 25089627 | Lnc2Cancer |
| EL0027 | PLAC9P1 | lung adenocarcinoma | microarray, qPCR etc. | lung adenocarcinoma tissue | down-regulated | expression | We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. | 25089627 | Lnc2Cancer |
| EL0031 | ACTA2-AS1 | lung adenocarcinoma | microarray, qPCR, knockdown etc. | lung adenocarcinoma tissue, cell lines (A549) | up-regulated | expression | Enhanced expression of long non-coding RNA ZXF1 promoted the invasion and metastasis in lung adenocarcinoma. | 24721325 | LncRNADisease Lnc2Cancer |
| EL0307 | AC130456.2 | lung adenocarcinoma | microarray, qPCR etc. | lung adenocarcinoma tissue | down-regulated | expression | We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. | 25089627 | Lnc2Cancer |
| EL0349 | DLX6-AS1 | lung adenocarcinoma | microarray, qPCR, Western blot etc. | lung cancer tissue, cell lines(A549, H1650 etc.) | up-regulated | expression | The expression level of lncRNA DLX6-AS1 in LAC tissues was significantly higher compared to paired adjacent normal lung tissues. In addition, its expression level was closed correlated with both histological differentiation and TNM stage. Down-regulation of lncRNA DLX6-AS1 expression decreased the DLX6 mRNA and protein levels. | 26052251 | Lnc2Cancer |
| EL0453 | LINC01852 | lung adenocarcinoma | microarray, qPCR etc. | lung adenocarcinoma tissue | down-regulated | expression | The remaining 10 lncRNAs, showed significantly different expression in the tumor samples. For 9 of these, expression was altered in the same direction as had been detected by microarray analysis (8 lower, and 1 higher, than NT samples; all p < 0.001; ).differentially expressed lncRNAs in early stage lung adenocarcinoma and suggest that lncRNAs may be novel candidate biomarkers for the early detection of this disease. | 25758555 | Lnc2Cancer |
| EL0455 | ENST00000442037 | lung adenocarcinoma | microarray, qPCR etc. | lung adenocarcinoma tissue | down-regulated | expression | The remaining 10 lncRNAs, showed significantly different expression in the tumor samples. For 9 of these, expression was altered in the same direction as had been detected by microarray analysis (8 lower, and 1 higher, than NT samples; all p < 0.001; ).differentially expressed lncRNAs in early stage lung adenocarcinoma and suggest that lncRNAs may be novel candidate biomarkers for the early detection of this disease. | 25758555 | Lnc2Cancer |
| EL0470 | AC026369.2 | lung adenocarcinoma | microarray, qPCR etc. | lung adenocarcinoma tissue | down-regulated | expression | The remaining 10 lncRNAs, showed significantly different expression in the tumor samples. For 9 of these, expression was altered in the same direction as had been detected by microarray analysis (8 lower, and 1 higher, than NT samples; all p < 0.001; ).differentially expressed lncRNAs in early stage lung adenocarcinoma and suggest that lncRNAs may be novel candidate biomarkers for the early detection of this disease. | 25758555 | Lnc2Cancer |
| EL0490 | FAR2P1 | lung adenocarcinoma | microarray, qPCR etc. | lung adenocarcinoma tissue | down-regulated | expression | RP11-133F8.2 expression of EGFR exon 19 deletions in lung adenocarcinoma was significantly higher than wild-type EGFR tissues, while LOC440905 expression of EGFR exon 19 deletions in lung adenocarcinoma was significantly lower than wild-type EGFR tissues. RP11-325I22.2 and LOC440905 might play an important role in the mechanism of EGFR exon 19 deletion in lung adenocarcinoma. | 25085781 | Lnc2Cancer |
| EL0526 | GAS5 | lung adenocarcinoma | qPCR, Western blot etc. | lung cancer tissue, cell lines (A549, H1299, H1975, HCC827) | down-regulated | interaction | Our results showed that GAS5 was significantly downregulated in lung adenocarcinoma tissues compared with the paired adjacent non-tumorous tissue samples. Furthermore, lower GAS5 expression levels were associated with larger tumor sizes, poor tumor differentiation, and advanced pathological stages. GAS5 overexpression was inversely correlated with the expression of the EGFR pathway and IGF-1R proteins. | 25925741 | Lnc2Cancer |
| EL0575 | HNF1A-AS1 | lung adenocarcinoma | qPCR, Western blot, knockdown, RIP etc. | lung adenocarcinoma tissue, cell lines (A549, SPC-A1, H1650) | up-regulated | interaction | HNF1A-AS1 was significantly up-regulated in lung adenocarcinoma tissues compared with corresponding non-tumor tissues, and its expression level was significantly correlated with TNM stage, tumor size, and lymph node metastasis. Moreover, HNF1A-AS1 was determined to promote tumor proliferation and metastasis, both in vitro and in vivo, by regulating cyclin D1, E-cadherin, N-cadherin and β-catenin expression. In addition, the binding of HNF1A-AS1 to DNMT1 may explain its regulation of E-cadherin. | 25863539 | Lnc2Cancer |
| EL0578 | HOTAIR | lung adenocarcinoma | N/A | N/A | N/A | regulation | In this study, the lncRNA HOTAIR was upregualted in lung adenocarcinoma cells grown in 3-D cell culture supplemented with collagen.? | 24829860 | LncRNADisease |
| EL0578 | HOTAIR | lung adenocarcinoma | qPCR, knockdown etc. | NSCLC and adjacent non-tumor lung tissues, cell lines (A549, PC9, H1299, H520, HBE) | up-regulated | interaction | HOTAIR regulates the ratio of FOXA1 to FOXA2 and migration and invasion. HOTAIR and the ratio of FOXA1 to FOXA2 are negatively correlated. HOTAIR knockdown inhibits migration and invasion. HOTAIR is associated with LSH, and this association linked with the binding of LSH in the promoter of FOXA1, not FOXA2. Targeted inhibition of HOTAIR suppresses the migratory and invasive properties | 26658322 | Lnc2Cancer |
| EL0578 | HOTAIR | lung adenocarcinoma | qPCR, Western blot, knockdown etc. | lung adenocarcinoma tissue, cell lines (A549/DDP, SPC-A1 etc.) | up-regulated | N/A | In this study, we show that HOTAIR expression was significantly upregulated in cisplatin-resistant A549/DDP cells compared with in parental A549 cells. Knockdown of HOTAIR by RNA interference could resensitize the responses of A549/DDP cells to cisplatin both in vitro and in vivo. In contrast, overexpression of HOTAIR could decrease the sensitivity of A549 and SPC-A1 cells to cisplatin. | 24155936 | Lnc2Cancer |
| EL0678 | LINC00987 | lung adenocarcinoma | microarray, qPCR etc. | lung adenocarcinoma tissue | down-regulated | expression | We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. | 25089627 | Lnc2Cancer |
| EL0688 | LINC01207 | lung adenocarcinoma | qPCR, Western blot, knockdown, RIP, ChIP etc. | NSCLC tissues and adjacent non-tumor tissues, cell lines(A549) | up-regulated | interaction | LINC01207 was significantly up-regulated in LAD tissues compared with paired non-tumor tissues, while there was no significant differences between LSCC tissues and adjacent non-tumor tissues. The expression level of LINC01207 was associated with TNM stage of LAD patients, and higher LINC01207 level indicated advanced TNM stage and shorter survival. | 26693067 | Lnc2Cancer |
| EL0700 | LINC01511 | lung adenocarcinoma | microarray, qPCR etc. | lung adenocarcinoma tissue | up-regulated | expression | RP11-133F8.2 expression of EGFR exon 19 deletions in lung adenocarcinoma was significantly higher than wild-type EGFR tissues, while LOC440905 expression of EGFR exon 19 deletions in lung adenocarcinoma was significantly lower than wild-type EGFR tissues. RP11-325I22.2 and LOC440905 might play an important role in the mechanism of EGFR exon 19 deletion in lung adenocarcinoma. | 25085781 | Lnc2Cancer |
| EL0701 | LINC01512 | lung adenocarcinoma | microarray, qPCR etc. | lung adenocarcinoma tissue | up-regulated | expression | We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. | 25089627 | Lnc2Cancer |
| EL0848 | LUADT1 | lung adenocarcinoma | microarray, qPCR, Western blot, knockdown, Luciferase reporter assay etc. | lung cancer tissues and adjacent non-tumor tissues, cell lines ( A549, H1975, H358, H1650 and H1299A549, H1975, H358, H1650 and H1299 ) | up-regulated | interaction | LUADT1 may regulate cell cycle progression by epigenetically inhibiting the expression of p27. RNA immunoprecipitation and chromatin immunoprecipitation assays confirmed that LUADT1 binds to SUZ12, a core component of polycomb repressive complex 2, and mediates the trimethylation of H3K27 at the promoter region of p27. The negative correlation between LUADT1 and p27 expression was confirmed in LUAD tissue samples. LUADT1 is an oncogenic lncRNA that regulates LUAD progression, suggesting that dysregulated lncRNAs may serve as key regulatory factors in LUAD progression | 26291312 | Lnc2Cancer |
| EL0852 | MAFA-AS1 | lung adenocarcinoma | microarray, qPCR etc. | lung adenocarcinoma tissue | up-regulated | expression | We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. | 25089627 | Lnc2Cancer |
| EL0853 | MALAT1 | lung adenocarcinoma | N/A | N/A | N/A | expression | Metastasis associated lung adenocarcinoma transcript 1 is up-regulated in placenta previa increta/percreta and strongly associated with trophoblast-like cell invasion in vitro. | 19690017 | LncRNADisease |
| EL0853 | MALAT1 | lung adenocarcinoma | qPCR etc. | cell line (A549 ) | differential expression | interaction | MALAT-1 is a novel class of non-coding RNA that promotes cell motility of lung adenocarcinoma cells through transcriptional and post-transcriptional regulation of motility related gene expression. | 20937273 | LncRNADisease Lnc2Cancer |
| EL0861 | MEG3 | lung adenocarcinoma | microarray, qPCR, Western blot etc. | lung cancer tissue, cell lines (A549 etc.) | down-regulated | interaction | MEG3 expression was markedly decreased in cisplatin-resistant A549/DDP cells compared with parental A549 cells as shown by an lncRNA microarray. MEG3 overexpression in A549/DDP cells increased their chemosensitivity to cisplatin both in vitro and in vivo by inhibiting cell proliferation and inducing apoptosis. Moreover, MEG3 was decreased in cisplatin-insensitive LAD tissues while p53 protein levels were decreased and Bcl-xl protein levels increased. | 25992654 | Lnc2Cancer |
| EL1008 | NR_038125 | lung adenocarcinoma | microarray, qPCR etc. | lung adenocarcinoma tissue | down-regulated | expression | The remaining 10 lncRNAs, showed significantly different expression in the tumor samples. For 9 of these, expression was altered in the same direction as had been detected by microarray analysis (8 lower, and 1 higher, than NT samples; all p < 0.001; ).differentially expressed lncRNAs in early stage lung adenocarcinoma and suggest that lncRNAs may be novel candidate biomarkers for the early detection of this disease. | 25758555 | Lnc2Cancer |
| EL1061 | PDLIM3 | lung adenocarcinoma | microarray, qPCR etc. | lung adenocarcinoma tissue | down-regulated | expression | The remaining 10 lncRNAs, showed significantly different expression in the tumor samples. For 9 of these, expression was altered in the same direction as had been detected by microarray analysis (8 lower, and 1 higher, than NT samples; all p < 0.001; ).differentially expressed lncRNAs in early stage lung adenocarcinoma and suggest that lncRNAs may be novel candidate biomarkers for the early detection of this disease. | 25758555 | Lnc2Cancer |
| EL1136 | LINC01513 | lung adenocarcinoma | microarray, qPCR etc. | lung adenocarcinoma tissue | down-regulated | expression | We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. | 25089627 | Lnc2Cancer |
| EL1145 | AL355870.1 | lung adenocarcinoma | microarray, qPCR etc. | lung adenocarcinoma tissue | down-regulated | expression | We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. | 25089627 | Lnc2Cancer |
| EL1147 | AC108134.4 | lung adenocarcinoma | microarray, qPCR etc. | lung adenocarcinoma tissue | down-regulated | expression | We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. | 25089627 | Lnc2Cancer |
| EL1156 | LINC01969 | lung adenocarcinoma | microarray, qPCR etc. | lung adenocarcinoma tissue | up-regulated | expression | We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. | 25089627 | Lnc2Cancer |
| EL1158 | RP13-514E23.1 | lung adenocarcinoma | microarray, qPCR etc. | lung adenocarcinoma tissue | down-regulated | expression | We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. | 25089627 | Lnc2Cancer |
| EL1159 | RP1-90D4.3 | lung adenocarcinoma | microarray, qPCR etc. | lung adenocarcinoma tissue | down-regulated | expression | We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. | 25089627 | Lnc2Cancer |
| EL1161 | AL109741.3 | lung adenocarcinoma | microarray, qPCR etc. | lung adenocarcinoma tissue | down-regulated | expression | We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. | 25089627 | Lnc2Cancer |
| EL1165 | AL445307.1 | lung adenocarcinoma | microarray, qPCR etc. | lung adenocarcinoma tissue | down-regulated | expression | We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. | 25089627 | Lnc2Cancer |
| EL1169 | RPLP0P2 | lung adenocarcinoma | microarray, qPCR etc. | lung adenocarcinoma tissue | down-regulated | expression | We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. | 25089627 | Lnc2Cancer |
| EL1414 | uc001gch.1 | lung adenocarcinoma | microarray, qPCR etc. | lung adenocarcinoma tissue | down-regulated | expression | The remaining 10 lncRNAs, showed significantly different expression in the tumor samples. For 9 of these, expression was altered in the same direction as had been detected by microarray analysis (8 lower, and 1 higher, than NT samples; all p < 0.001; ).differentially expressed lncRNAs in early stage lung adenocarcinoma and suggest that lncRNAs may be novel candidate biomarkers for the early detection of this disease. | 25758555 | Lnc2Cancer |
| EL1415 | uc001gzl.3 | lung adenocarcinoma | microarray, qPCR etc. | lung adenocarcinoma tissue | up-regulated | expression | The remaining 10 lncRNAs, showed significantly different expression in the tumor samples. For 9 of these, expression was altered in the same direction as had been detected by microarray analysis (8 lower, and 1 higher, than NT samples; all p < 0.001; ).differentially expressed lncRNAs in early stage lung adenocarcinoma and suggest that lncRNAs may be novel candidate biomarkers for the early detection of this disease. | 25758555 | Lnc2Cancer |
| EL1426 | uc004bbl.1 | lung adenocarcinoma | microarray, qPCR etc. | lung adenocarcinoma tissue | down-regulated | expression | The remaining 10 lncRNAs, showed significantly different expression in the tumor samples. For 9 of these, expression was altered in the same direction as had been detected by microarray analysis (8 lower, and 1 higher, than NT samples; all p < 0.001; ).differentially expressed lncRNAs in early stage lung adenocarcinoma and suggest that lncRNAs may be novel candidate biomarkers for the early detection of this disease. | 25758555 | Lnc2Cancer |
| EL1447 | VNN2 | lung adenocarcinoma | microarray, qPCR etc. | lung adenocarcinoma tissue | down-regulated | expression | The remaining 10 lncRNAs, showed significantly different expression in the tumor samples. For 9 of these, expression was altered in the same direction as had been detected by microarray analysis (8 lower, and 1 higher, than NT samples; all p < 0.001; ).differentially expressed lncRNAs in early stage lung adenocarcinoma and suggest that lncRNAs may be novel candidate biomarkers for the early detection of this disease. | 25758555 | Lnc2Cancer |
| EL1474 | XLOC_003286 | lung adenocarcinoma | microarray, qPCR etc. | lung adenocarcinoma tissue | down-regulated | expression | We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. | 25089627 | Lnc2Cancer |
| EL1475 | XLOC_003405 | lung adenocarcinoma | microarray, qPCR etc. | lung adenocarcinoma tissue | up-regulated | expression | We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. | 25089627 | Lnc2Cancer |
| EL1501 | XLOC_012255 | lung adenocarcinoma | microarray, qPCR etc. | lung adenocarcinoma tissue | down-regulated | expression | We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. | 25089627 | Lnc2Cancer |
| EL1526 | ZNF295-AS1 | lung adenocarcinoma | microarray, qPCR etc. | lung adenocarcinoma tissue | down-regulated | expression | We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. | 25089627 | Lnc2Cancer |