Related LncRNAs |
ID |
lncRNA Name |
Disease |
Method |
Sample |
Expression pattern |
Dysfunction type |
Description |
PMID |
Source |
EL0227 |
BANCR |
hepatocellular carcinoma |
quantitative real-time PCR (qRT-PCR), overexpression, downregulation, flow cytometry, and transwell invasion and migration assays |
human hepatocellular carcinoma tissues |
up-regulated |
expression |
BANCR may contribute to HCC initiation and progression and would be used as not only a novel prognostic marker but also a potential therapeutic target for this disease. |
26758762 |
|
EL0310 |
CTBP1-AS |
hepatocellular carcinoma |
RT-qPCR |
serum |
N/A |
N/A |
high sensitivity and specificity for discriminating HCC from healthy controls and also from CHC patients |
27113935 |
|
EL0575 |
HNF1A-AS1 |
hepatocellular carcinoma |
N/A |
HCC tissue and cell line |
up-regulated |
N/A |
sponging tumor-suppressive hsa-miR-30b-5p (miR-30b) and de-repressing Bcl-2 |
27084450 |
|
EL0600 |
HULC |
hepatocellular carcinoma |
qPCR, Western blot, Luciferase reporter assay etc. |
HCC tissue, cell lines (L-O2 cell line, L-O2-X) |
up-regulated |
expression |
Our data show that an lncRNA, HULC, is responsible for the perturbations in circadian rhythm through upregulating circadian oscillator CLOCK in hepatoma cells, resulting in the promotion of hepatocarcinogenesis. Mechanistically, the complementary base pairing between HULC and the 5'untranslated region of CLOCK mRNA underlay the HULC-modulated expression of CLOCK, and the mutants in the complementary region failed to achieve the event. |
25622901 |
Lnc2Cancer
|
EL0853 |
MALAT1 |
hepatocellular carcinoma |
N/A |
hepatocellular carcinoma (HCC) tissues |
up-regulated |
interaction |
N/A |
26352013 |
|
EL0861 |
MEG3 |
hepatocellular carcinoma |
methylation specific PCR (MSP), qRT-PCR, RNA pulldown and western blot analysis, MTT assay, fluorescence microscopy and flow cytometry, improved MS2 biotin tagged RNA affinity purification method |
hepatoma HepG2 and Huh7 cells |
up-regulated |
interaction |
Ectopic expression of MEG3 inhibited hepatoma cell growth in a time-dependent manner, resulted in cell cycle arrest and induced apoptosis. Adenosine increases MEG3 expression by inhibition of DNA methylation and its antitumor effects is involved in MEG3 activation. |
26647875 |
|
EL1363 |
TRERNA1 |
hepatocellular carcinoma |
N/A |
hepatoma cells |
N/A |
expression |
miR-190a can silence treRNA post-transcriptionally. Suppression of treRNA by miR-190a led to significant changes of mesenchymal-epithelial transition markers and impaired migration and invasion capability of hepatoma cells. |
26608035 |
|
|