Related LncRNAs |
ID |
lncRNA Name |
Disease |
Method |
Sample |
Expression pattern |
Dysfunction type |
Description |
PMID |
Source |
EL0276 |
CCAT1 |
gallbladder cancer |
qPCR, Luciferase reporter assay, Western blot etc. |
gallbladder cancer tissue |
up-regulated |
expression |
In this study, we demonstrated that CCAT1 was upregulated in gallbladder cancer (GBC) tissues. CCAT1 silencing downregulated, whereas CCAT1 overexpression enhanced the expression of miRNA-218-5p target gene Bmi1 through competitively 'spongeing' miRNA-218-5p. Our data revealed that CCAT1 knockdown impaired the proliferation and invasiveness of GBC cells, at least in part through affetcing miRNA-218-5p-mediated regulation of Bmi1. Moreover, CCAT1 transcript level was correlated with Bmi1 mRNA level in GBC tissues. |
25569100 |
Lnc2Cancer
|
EL0487 |
FAM30A |
gallbladder cancer |
qPCR etc. |
GBC cell sublines(GBC-SD, GBC-SD/M) |
up-regulated |
interaction |
We found the differential expression of a lncRNA, namely, KIAA0125, in a pair of GBC cell sublines which possess different metastatic potentials. Then the effects of KIAA0125 on GBC cell migration, invasion, and epithelial-mesenchymal transitions (EMT) were investigated by using a lentivirus-mediated RNA interference (RNAi) system. Notably, cell migration and invasion were strongly inhibited by KIAA0125 suppression. Moreover, the expression of β-catenin was increased and the expression of Vimentin was decreased in GBC-SD/M cells after KIAA0125 knockdown. |
26448925 |
Lnc2Cancer
|
EL0556 |
H19 |
gallbladder cancer |
gallbladder cancer |
gallbladder cancer tissues and adjacent normal tissues |
up-regulated |
N/A |
The overexpression of H19 in GBC cells enhanced tumor invasion and promoted EMT |
27073719 |
|
EL0578 |
HOTAIR |
gallbladder cancer |
qPCR, Northern blot, in vitro knockdown, RIP etc. |
gallbladder cancer tissue, cell lines (GBC-SD, SGC-996,NOZ, EH-GB2 etc.) |
up-regulated |
N/A |
The HOTAIR transcripts were expressed at higher levels in the tumor tissues compared with adjacent normal tissues (p < 0.0001), indicating that HOTAIR was frequently up-regulated in GBC.A positive correlation between c-Myc and HOTAIR mRNA levels was observed in gallbladder cancer tissues. HOTAIR is a c-Myc-activated driver of malignancy, which acts in part through repression of miRNA-130a. |
24953832 |
Lnc2Cancer
|
EL0853 |
MALAT1 |
gallbladder cancer |
qPCR, Western blot etc. |
GBC tissue, cell lines (SGC-996, NOZ) |
up-regulated |
regulation |
MALAT1 promotes the proliferation and metastasis of gallbladder cancer cells by activating the ERK/MAPK pathway. |
24658096 |
LncRNADisease Lnc2Cancer
|
EL1007 |
NPTN-IT1 |
gallbladder cancer |
qPCR, Western blot, FCA etc. |
gallbladder cancer tissue, cell lines (GBC-SD, SGC-996, NOZ, EH-GB2) |
down-regulated |
expression |
In the present study, an obvious down-regulation of lncRNA-LET was observed in gallbladder cancer compared to their adjacent normal tissues. Meanwhile, patients with low expression of lncRNA-LET have significantly poorer prognosis than those with high expression. We confirmed that hypoxia decreased lncRNA-LET levels in gallbladder cancer cells. Moreover, lncRNA-LET overexpression was further validated to inhibit the invasion of gallbladder cancer cells under hypoxic or normoxic conditions in vitro. We demonstrated that lncRNA-LET overexpression conferred a proliferative advantage to tumor cells under hypoxic conditions. |
25213660 |
Lnc2Cancer
|
|