| Related LncRNAs | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| ID | lncRNA Name | Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source |
| EL0276 | CCAT1 | gallbladder cancer | qPCR, Luciferase reporter assay, Western blot etc. | gallbladder cancer tissue | up-regulated | expression | In this study, we demonstrated that CCAT1 was upregulated in gallbladder cancer (GBC) tissues. CCAT1 silencing downregulated, whereas CCAT1 overexpression enhanced the expression of miRNA-218-5p target gene Bmi1 through competitively 'spongeing' miRNA-218-5p. Our data revealed that CCAT1 knockdown impaired the proliferation and invasiveness of GBC cells, at least in part through affetcing miRNA-218-5p-mediated regulation of Bmi1. Moreover, CCAT1 transcript level was correlated with Bmi1 mRNA level in GBC tissues. | 25569100 | Lnc2Cancer |
| EL0487 | FAM30A | gallbladder cancer | qPCR etc. | GBC cell sublines(GBC-SD, GBC-SD/M) | up-regulated | interaction | We found the differential expression of a lncRNA, namely, KIAA0125, in a pair of GBC cell sublines which possess different metastatic potentials. Then the effects of KIAA0125 on GBC cell migration, invasion, and epithelial-mesenchymal transitions (EMT) were investigated by using a lentivirus-mediated RNA interference (RNAi) system. Notably, cell migration and invasion were strongly inhibited by KIAA0125 suppression. Moreover, the expression of β-catenin was increased and the expression of Vimentin was decreased in GBC-SD/M cells after KIAA0125 knockdown. | 26448925 | Lnc2Cancer |
| EL0556 | H19 | gallbladder cancer | gallbladder cancer | gallbladder cancer tissues and adjacent normal tissues | up-regulated | N/A | The overexpression of H19 in GBC cells enhanced tumor invasion and promoted EMT | 27073719 | |
| EL0578 | HOTAIR | gallbladder cancer | qPCR, Northern blot, in vitro knockdown, RIP etc. | gallbladder cancer tissue, cell lines (GBC-SD, SGC-996,NOZ, EH-GB2 etc.) | up-regulated | N/A | The HOTAIR transcripts were expressed at higher levels in the tumor tissues compared with adjacent normal tissues (p < 0.0001), indicating that HOTAIR was frequently up-regulated in GBC.A positive correlation between c-Myc and HOTAIR mRNA levels was observed in gallbladder cancer tissues. HOTAIR is a c-Myc-activated driver of malignancy, which acts in part through repression of miRNA-130a. | 24953832 | Lnc2Cancer |
| EL0853 | MALAT1 | gallbladder cancer | qPCR, Western blot etc. | GBC tissue, cell lines (SGC-996, NOZ) | up-regulated | regulation | MALAT1 promotes the proliferation and metastasis of gallbladder cancer cells by activating the ERK/MAPK pathway. | 24658096 | LncRNADisease Lnc2Cancer |
| EL1007 | NPTN-IT1 | gallbladder cancer | qPCR, Western blot, FCA etc. | gallbladder cancer tissue, cell lines (GBC-SD, SGC-996, NOZ, EH-GB2) | down-regulated | expression | In the present study, an obvious down-regulation of lncRNA-LET was observed in gallbladder cancer compared to their adjacent normal tissues. Meanwhile, patients with low expression of lncRNA-LET have significantly poorer prognosis than those with high expression. We confirmed that hypoxia decreased lncRNA-LET levels in gallbladder cancer cells. Moreover, lncRNA-LET overexpression was further validated to inhibit the invasion of gallbladder cancer cells under hypoxic or normoxic conditions in vitro. We demonstrated that lncRNA-LET overexpression conferred a proliferative advantage to tumor cells under hypoxic conditions. | 25213660 | Lnc2Cancer |