Related LncRNAs |
ID |
lncRNA Name |
Disease |
Method |
Sample |
Expression pattern |
Dysfunction type |
Description |
PMID |
Source |
EL0028 |
AC100865.1 |
coronary artery disease |
microarray, qPCR |
plasma from coronary artery disease (CAD) patients |
up-regulated |
expression |
The present study screened lncRNAs by microarray analysis in the plasma from CAD patients and control individuals and found that 265 lncRNAs were differentially expressed. Receiver operating characteristic (ROC) curve analysis showed that lncRNA AC100865.1(referred to as CoroMarker) was the best of these lncRNAs. |
26201019 |
|
EL0289 |
CDKN2B-AS1 |
coronary artery disease |
N/A |
N/A |
N/A |
mutation |
Sequence polymorphisms in a 58-kilobase (kb) interval on chromosome 9p21 confer a markedly increased risk (rs3217992, A>G;rs1063192, C>T) of coronary artery disease (CAD), the leading cause of death worldwide. |
17554300 |
LncRNADisease
|
EL0289 |
CDKN2B-AS1 |
coronary artery disease |
N/A |
N/A |
N/A |
mutation |
Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs (rs2891168, A>G) in the ANRIL locus on chromosome 9p. |
18048406 |
LncRNADisease
|
EL0289 |
CDKN2B-AS1 |
coronary artery disease |
N/A |
N/A |
N/A |
expression |
Significantly reduced expression of all INK4/ARF transcripts (p15(INK4b), p16(INK4a), ARF and ANRIL) was found in PBTL of individuals harboring a common SNP (rs10757278) associated with increased risk of coronary artery disease, stroke and aortic aneurysm. |
19343170 |
LncRNADisease
|
EL0289 |
CDKN2B-AS1 |
coronary artery disease |
N/A |
N/A |
N/A |
expression |
Whole blood RNA expression of the short variants of ANRIL was increased by 2.2-fold whereas expression of the long ANRIL variant was decreased by 1.2-fold in healthy subjects homozygous for the risk allele. Expression levels of the long and short ANRIL variants were positively correlated with that of the cyclin-dependent kinase inhibitor, CDKN2B (p15) and TDGF1 (Cripto), respectively. |
19592466 |
LncRNADisease
|
EL0289 |
CDKN2B-AS1 |
coronary artery disease |
N/A |
N/A |
N/A |
expression |
However, overexpression of 1 ANRIL variant altered the expression of many genes involved in nuclear regulation and chromatin architecture, indicating diverse trans-regulatory effects that go beyond the cis-effects seen at 9p21. |
23104877 |
LncRNADisease
|
EL0556 |
H19 |
coronary artery disease |
N/A |
N/A |
N/A |
N/A |
Re-expression of H19 has been observed in patients with atherosclerosis. Common polymorphisms of H19 are associated with the risk and severity of CAD in a Chinese population. |
25772106 |
LncRNADisease
|
|