| Related LncRNAs | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| ID | lncRNA Name | Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source |
| EL0265 | CADM1 | clear cell renal cell carcinoma | qPCR, knockdown etc. | renal cancer tissue, cell lines(786-O, ACHN etc.) | down-regulated | interaction | The results showed that CADM1-AS1 expression was down-regulated in tumor tissues in 64 patients with ccRCC compared with adjacent non-tumor tissues. Furthermore, the expression of CADM1-AS1 was positively correlated with the expression of mRNA CADM1 in ccRCC specimens. Decreased CADM1-AS1 expression was correlated with the progression of AJCC stage and worse survival of ccRCC patients. Also, multivariate analysis identified low CADM1-AS1 expression as an independent prognostic factor for ccRCC.CADM1-AS1 is a new tumor suppressor in ccRCC which regulates cell proliferation, apoptosis and migration via the expression pattern of CADM1-AS1/CADM1 mRNA gene pairs. | 25031695 | Lnc2Cancer |
| EL0336 | DGCR5 | clear cell renal cell carcinoma | microarray, qPCR etc. | renal clear cell carcinoma tissue | up-regulated | N/A | ENST00000456816, X91348, BC029135, NR_024418 were evaluated by qPCR in sixty-three pairs of RCCC and NT samples. The results demonstrated that ENST00000456816, X91348 were up-regulated and BC029135, NR_024418 were down-regulated in RCCC samples compared with NT samples (p<0.001 for each lncRNAs). | 22879955 | Lnc2Cancer |
| EL0461 | LINC00887 | clear cell renal cell carcinoma | microarray, qPCR etc. | renal clear cell carcinoma tissue | up-regulated | N/A | ENST00000456816, X91348, BC029135, NR_024418 were evaluated by qPCR in sixty-three pairs of RCCC and NT samples. The results demonstrated that ENST00000456816, X91348 were up-regulated and BC029135, NR_024418 were down-regulated in RCCC samples compared with NT samples (p<0.001 for each lncRNAs). | 22879955 | Lnc2Cancer |
| EL0556 | H19 | clear cell renal cell carcinoma | qRT-PCR, siRNA | clear cell renal carcinoma (ccRCC) tissues and renal cancer cell lines | up-regulated | expression | lncRNA H19 might be considered as a potential prognostic indicator and a target for gene therapy of ccRCC. | 25866221 | |
| EL0760 | lnc-ACACA-1 | clear cell renal cell carcinoma | microarray, qPCR etc. | ccRCC tissue | down-regulated | expression | Among these, aberrant expression was validated using PCR: lnc-BMP2-2, lnc-CPN2-1, lnc-FZD1-2, lnc-ITPR2-3, lnc-SLC30A4-1, and lnc-SPAM1-6 were highly overexpressed in ccRCC, whereas lnc-ACACA-1, lnc-FOXG1-2, lnc-LCP2-2, lnc-RP3-368B9, and lnc-TTC34-3 were downregulated. Computational analyses revealed that these lncRNAs are involved in RNA-protein networks related to splicing, binding, transport, localization, and processing of RNA. | 25685243 | Lnc2Cancer |
| EL0765 | lnc-BMP2-2 | clear cell renal cell carcinoma | microarray, qPCR etc. | ccRCC tissue | up-regulated | expression | Among these, aberrant expression was validated using PCR: lnc-BMP2-2, lnc-CPN2-1, lnc-FZD1-2, lnc-ITPR2-3, lnc-SLC30A4-1, and lnc-SPAM1-6 were highly overexpressed in ccRCC, whereas lnc-ACACA-1, lnc-FOXG1-2, lnc-LCP2-2, lnc-RP3-368B9, and lnc-TTC34-3 were downregulated. Computational analyses revealed that these lncRNAs are involved in RNA-protein networks related to splicing, binding, transport, localization, and processing of RNA. | 25685243 | Lnc2Cancer |
| EL0766 | lnc-CPN2-1 | clear cell renal cell carcinoma | microarray, qPCR etc. | ccRCC tissue | up-regulated | expression | Among these, aberrant expression was validated using PCR: lnc-BMP2-2, lnc-CPN2-1, lnc-FZD1-2, lnc-ITPR2-3, lnc-SLC30A4-1, and lnc-SPAM1-6 were highly overexpressed in ccRCC, whereas lnc-ACACA-1, lnc-FOXG1-2, lnc-LCP2-2, lnc-RP3-368B9, and lnc-TTC34-3 were downregulated. Computational analyses revealed that these lncRNAs are involved in RNA-protein networks related to splicing, binding, transport, localization, and processing of RNA. | 25685243 | Lnc2Cancer |
| EL0767 | lnc-CYP4A22-2/3 | clear cell renal cell carcinoma | microarray, qPCR etc. | ccRCC tissue | up-regulated | expression | lnc-ZNF180-2 levels were similar in localized ccRCC and normal renal tissue, but we observed a significant increase of lnc-ZNF180-2 expression in advanced ccRCC tissue. Furthermore, lnc-ZNF180-2 expression levels were an independent predictor of progression-free survival, cancer-specific survival and overall survival in ccRCC patients. We also observed that lnc-CYP4A22-2/3 expression levels allowed discrimination of ccRCC and normal renal tissue. In conclusion, lncRNAs are involved in renal carcinogenesis, and quantification of lnc-ZNF180-2 may be useful for the prediction of ccRCC patients outcome following nephrectomy. | 26609485 | Lnc2Cancer |
| EL0769 | lnc-FOXG1-2 | clear cell renal cell carcinoma | microarray, qPCR etc. | ccRCC tissue | down-regulated | expression | Among these, aberrant expression was validated using PCR: lnc-BMP2-2, lnc-CPN2-1, lnc-FZD1-2, lnc-ITPR2-3, lnc-SLC30A4-1, and lnc-SPAM1-6 were highly overexpressed in ccRCC, whereas lnc-ACACA-1, lnc-FOXG1-2, lnc-LCP2-2, lnc-RP3-368B9, and lnc-TTC34-3 were downregulated. Computational analyses revealed that these lncRNAs are involved in RNA-protein networks related to splicing, binding, transport, localization, and processing of RNA. | 25685243 | Lnc2Cancer |
| EL0770 | lnc-FZD1-2 | clear cell renal cell carcinoma | microarray, qPCR etc. | ccRCC tissue | up-regulated | expression | Among these, aberrant expression was validated using PCR: lnc-BMP2-2, lnc-CPN2-1, lnc-FZD1-2, lnc-ITPR2-3, lnc-SLC30A4-1, and lnc-SPAM1-6 were highly overexpressed in ccRCC, whereas lnc-ACACA-1, lnc-FOXG1-2, lnc-LCP2-2, lnc-RP3-368B9, and lnc-TTC34-3 were downregulated. Computational analyses revealed that these lncRNAs are involved in RNA-protein networks related to splicing, binding, transport, localization, and processing of RNA. | 25685243 | Lnc2Cancer |
| EL0771 | lnc-ITPR2-3 | clear cell renal cell carcinoma | microarray, qPCR etc. | ccRCC tissue | up-regulated | expression | Among these, aberrant expression was validated using PCR: lnc-BMP2-2, lnc-CPN2-1, lnc-FZD1-2, lnc-ITPR2-3, lnc-SLC30A4-1, and lnc-SPAM1-6 were highly overexpressed in ccRCC, whereas lnc-ACACA-1, lnc-FOXG1-2, lnc-LCP2-2, lnc-RP3-368B9, and lnc-TTC34-3 were downregulated. Computational analyses revealed that these lncRNAs are involved in RNA-protein networks related to splicing, binding, transport, localization, and processing of RNA. | 25685243 | Lnc2Cancer |
| EL0774 | lnc-LCP2-2 | clear cell renal cell carcinoma | microarray, qPCR etc. | ccRCC tissue | down-regulated | expression | Among these, aberrant expression was validated using PCR: lnc-BMP2-2, lnc-CPN2-1, lnc-FZD1-2, lnc-ITPR2-3, lnc-SLC30A4-1, and lnc-SPAM1-6 were highly overexpressed in ccRCC, whereas lnc-ACACA-1, lnc-FOXG1-2, lnc-LCP2-2, lnc-RP3-368B9, and lnc-TTC34-3 were downregulated. Computational analyses revealed that these lncRNAs are involved in RNA-protein networks related to splicing, binding, transport, localization, and processing of RNA. | 25685243 | Lnc2Cancer |
| EL0805 | lnc-RP3-368B9 | clear cell renal cell carcinoma | microarray, qPCR etc. | ccRCC tissue | down-regulated | expression | Among these, aberrant expression was validated using PCR: lnc-BMP2-2, lnc-CPN2-1, lnc-FZD1-2, lnc-ITPR2-3, lnc-SLC30A4-1, and lnc-SPAM1-6 were highly overexpressed in ccRCC, whereas lnc-ACACA-1, lnc-FOXG1-2, lnc-LCP2-2, lnc-RP3-368B9, and lnc-TTC34-3 were downregulated. Computational analyses revealed that these lncRNAs are involved in RNA-protein networks related to splicing, binding, transport, localization, and processing of RNA. | 25685243 | Lnc2Cancer |
| EL0806 | lnc-SLC30A4-1 | clear cell renal cell carcinoma | microarray, qPCR etc. | ccRCC tissue | up-regulated | expression | Among these, aberrant expression was validated using PCR: lnc-BMP2-2, lnc-CPN2-1, lnc-FZD1-2, lnc-ITPR2-3, lnc-SLC30A4-1, and lnc-SPAM1-6 were highly overexpressed in ccRCC, whereas lnc-ACACA-1, lnc-FOXG1-2, lnc-LCP2-2, lnc-RP3-368B9, and lnc-TTC34-3 were downregulated. Computational analyses revealed that these lncRNAs are involved in RNA-protein networks related to splicing, binding, transport, localization, and processing of RNA. | 25685243 | Lnc2Cancer |
| EL0807 | lnc-SPAM1-6 | clear cell renal cell carcinoma | microarray, qPCR etc. | ccRCC tissue | up-regulated | expression | Among these, aberrant expression was validated using PCR: lnc-BMP2-2, lnc-CPN2-1, lnc-FZD1-2, lnc-ITPR2-3, lnc-SLC30A4-1, and lnc-SPAM1-6 were highly overexpressed in ccRCC, whereas lnc-ACACA-1, lnc-FOXG1-2, lnc-LCP2-2, lnc-RP3-368B9, and lnc-TTC34-3 were downregulated. Computational analyses revealed that these lncRNAs are involved in RNA-protein networks related to splicing, binding, transport, localization, and processing of RNA. | 25685243 | Lnc2Cancer |
| EL0808 | lnc-TTC34-3 | clear cell renal cell carcinoma | microarray, qPCR etc. | ccRCC tissue | down-regulated | expression | Among these, aberrant expression was validated using PCR: lnc-BMP2-2, lnc-CPN2-1, lnc-FZD1-2, lnc-ITPR2-3, lnc-SLC30A4-1, and lnc-SPAM1-6 were highly overexpressed in ccRCC, whereas lnc-ACACA-1, lnc-FOXG1-2, lnc-LCP2-2, lnc-RP3-368B9, and lnc-TTC34-3 were downregulated. Computational analyses revealed that these lncRNAs are involved in RNA-protein networks related to splicing, binding, transport, localization, and processing of RNA. | 25685243 | Lnc2Cancer |
| EL0810 | lnc-ZNF180-2 | clear cell renal cell carcinoma | microarray, qPCR etc. | ccRCC tissue | down-regulated | expression | lnc-ZNF180-2 levels were similar in localized ccRCC and normal renal tissue, but we observed a significant increase of lnc-ZNF180-2 expression in advanced ccRCC tissue. Furthermore, lnc-ZNF180-2 expression levels were an independent predictor of progression-free survival, cancer-specific survival and overall survival in ccRCC patients. We also observed that lnc-CYP4A22-2/3 expression levels allowed discrimination of ccRCC and normal renal tissue. In conclusion, lncRNAs are involved in renal carcinogenesis, and quantification of lnc-ZNF180-2 may be useful for the prediction of ccRCC patients outcome following nephrectomy. | 26609485 | Lnc2Cancer |
| EL0828 | LOC389332 | clear cell renal cell carcinoma | microarray, qPCR etc. | renal clear cell carcinoma tissue | down-regulated | N/A | ENST00000456816, X91348, BC029135, NR_024418 were evaluated by qPCR in sixty-three pairs of RCCC and NT samples. The results demonstrated that ENST00000456816, X91348 were up-regulated and BC029135, NR_024418 were down-regulated in RCCC samples compared with NT samples (p<0.001 for each lncRNAs). | 22879955 | Lnc2Cancer |
| EL0853 | MALAT1 | clear cell renal cell carcinoma | qPCR, knockdown etc. | ccRCC tissue, cell line (HK-2) | up-regulated | expression | The expression level of MALAT1 was higher in ccRCC tissues and renal cancer cells compared to adjacent non-tumor tissues and normal human proximal tubule epithelial cells HK-2. The ccRCC patients with higher MALAT1 expression had an advanced clinical features and a shorter overall survival time than those with lower MALAT1 expression. Additionally, our data indicated that knockdown expression of MALAT1 decreased renal cancer cell proliferation, migration, and invasion. | 25480417 | Lnc2Cancer |
| EL0861 | MEG3 | clear cell renal cell carcinoma | qPCR, Western blot, FCA etc. | ccRCC tissue, cell lines (786-0, SN1) | down-regulated | interaction | The results showed that MEG3 was downregulated in RCC tissues and RCC cell lines. Overexpression of MEG3 could reduce the expression of Bcl-2 and procaspase-9 proteins, enhance the expression of cleaved caspase-9 protein, and promote the release of cytochrome c protein to cytoplasm. Additionally, Bcl-2 mRNA level was declined by MEG3 overexpression. It was concluded that MEG3 induces the apoptosis of RCC cells possibly by activating the mitochondrial pathway. | 26223924 | Lnc2Cancer |
| EL0961 | NBAT1 | clear cell renal cell carcinoma | qPCR, knockdown etc. | ccRCC tissue, cell lines (786-O, ACHN, Caki-1 etc.) | down-regulated | expression | NBAT-1 expression is significantly decreased in ccRCC tissues and renal cancer cells compared with adjacent normal tissues and normal human proximal tubule epithelial cell line HK-2, and its low level is associated with advanced features and poor prognosis. NBAT-1 is a novel molecular correlated with ccRCC progression and it may represent a prognostic biomarker and therapeutic target in renal cancer diagnosis and treatment. | 26097558 | Lnc2Cancer |
| EL1240 | SPRY4-IT1 | clear cell renal cell carcinoma | qPCR, knockdown etc. | ccRCC tissue, cell lines (786-O, ACHN, Caki-1, Caki-2) | up-regulated | expression | The relative level of SPRY4-IT1 was significantly higher in ccRCC tissues compared to the adjacent normal renal tissues. And higher expression of SPRY4-IT1 was found in renal cancer cell lines compared with the normal human proximal tubule epithelial cell line HK-2. The ccRCC patients with higher SPRY4-IT1 expression had an advanced clinical stage and poorer prognosis than those with lower SPRY4-IT1 expression. | 25337221 | Lnc2Cancer |
| EL1343 | TMEM72 | clear cell renal cell carcinoma | microarray, qPCR etc. | renal clear cell carcinoma tissue | down-regulated | N/A | ENST00000456816, X91348, BC029135, NR_024418 were evaluated by qPCR in sixty-three pairs of RCCC and NT samples. The results demonstrated that ENST00000456816, X91348 were up-regulated and BC029135, NR_024418 were down-regulated in RCCC samples compared with NT samples (p<0.001 for each lncRNAs). | 22879955 | Lnc2Cancer |