LncRNA Information
ID EL0336 Name DGCR5 Aliases LINC00037; NCRNA00037
Species Homo sapiens Chromosome 22 Start site 18970525
End site 19031242 Chain plus Exon NO. 6
Assembly Ensembl Release 89 Class processed transcript NCBI accession NR_110533, NR_002733, NR_045121
Ensembl ENSG00000283406 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
clear cell renal cell carcinoma microarray, qPCR etc. renal clear cell carcinoma tissue up-regulated N/A ENST00000456816, X91348, BC029135, NR_024418 were evaluated by qPCR in sixty-three pairs of RCCC and NT samples. The results demonstrated that ENST00000456816, X91348 were up-regulated and BC029135, NR_024418 were down-regulated in RCCC samples compared with NT samples (p<0.001 for each lncRNAs). 22879955 Lnc2Cancer
DiGeorge syndrome N/A N/A N/A expression The DiGeorge syndrome-associated noncoding RNA, DGCR5, is repressed by REST through a proximal upstream binding site. 19050060 LncRNADisease
velocardiofacial syndrome N/A N/A N/A N/A Association 20380817 LncRNADisease
Huntington's disease N/A N/A N/A expression Interestingly, many of these lncRNAs contain genomic binding sites for the transcriptional repressor REST, a key mediator of transcriptional changes in HD, including the known REST target lncRNA, DGCR5. 23346095 LncRNADisease
DiGeorge syndrome N/A N/A N/A mutation DGCR5 is disrupted by the patient ADU breakpoint. 8659529 LncRNADisease
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
REST DNA-TF regulation The DiGeorge syndrome-associated noncoding RNA, DGCR5, is repressed by REST through a proximal upstream binding site. 19050060 LncRNADisease