| Related LncRNAs | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| ID | lncRNA Name | Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source |
| EL0343 | DLEU1 | chronic lymphocytic leukemia | chromatin-immunoprecipitation (ChIP) that are associated with activated transcription; semi-quantitative and quantitative methods (aPRIMES, BioCOBRA, MCIp, MassARRAY, and bisulfite sequencing) | CLL cells | N/A | N/A | the tumor suppressor mechanism at 13q14.3 is a cluster of genes controlled by two lncRNA | 23593011 | |
| EL0343 | DLEU1 | chronic lymphocytic leukemia | qPCR etc. | blood | differential expression | locus | In 13q14.3, where several tumor suppressor genes, including the miRNA genes miR-16-1 and miR-15a, are co-regulated by the two long non-coding RNA genes DLEU1 and DLEU2 that span the critical region. | 19347735 | LncRNADisease Lnc2Cancer |
| EL0343 | DLEU1 | chronic lymphocytic leukemia | qPCR, FISH etc. | blood | down-regulated | mutation | Frequently deleted in B-cell chronic lymphocytic leukemia. | 11161783 | LncRNADisease Lnc2Cancer |
| EL0343 | DLEU1 | chronic lymphocytic leukemia | qPCR, FISH etc. | blood | differential expression | N/A | Leu1 and Leu2 genes are strong candidates as tumor suppressor gene(s) involved in B-CLL leukemogenesis. | 9395242 | LncRNADisease Lnc2Cancer |
| EL0344 | DLEU2 | chronic lymphocytic leukemia | chromatin immunoprecipitation assay, small interfering RNA-mediated repression | CLL patients, Human Burkitt’s lymphoma cell line Daudi | down-regulated | N/A | The transcription factor BSAP (B-cell-specific activator protein) directly interacts with Dleu2, the host gene containing the miR-15a/16-1 loci, and by negative regulation of the Dleu2 promoter, results in repression of miR-15a/16-1 expression. | 23995789 | |
| EL0344 | DLEU2 | chronic lymphocytic leukemia | chromatin-immunoprecipitation (ChIP) that are associated with activated transcription; semi-quantitative and quantitative methods (aPRIMES, BioCOBRA, MCIp, MassARRAY, and bisulfite sequencing) | CLL cells | N/A | N/A | the tumor suppressor mechanism at 13q14.3 is a cluster of genes controlled by two lncRNA | 23593011 | |
| EL0344 | DLEU2 | chronic lymphocytic leukemia | N/A | N/A | N/A | N/A | DLEU2, which encodes miR-15a and miR-16-1, was discovered from 13q14 deletion in chronic lymphocytic leukemia | 23551855 | |
| EL0344 | DLEU2 | chronic lymphocytic leukemia | qPCR etc. | blood | differential expression | locus | In 13q14.3, where several tumor suppressor genes, including the miRNA genes miR-16-1 and miR-15a, are co-regulated by the two long non-coding RNA genes DLEU1 and DLEU2 that span the critical region. | 19347735 | LncRNADisease Lnc2Cancer |
| EL0344 | DLEU2 | chronic lymphocytic leukemia | qPCR, FISH etc. | blood | down-regulated | mutation | Frequently deleted in B-cell chronic lymphocytic leukemia. | 11161783 | LncRNADisease Lnc2Cancer |
| EL0344 | DLEU2 | chronic lymphocytic leukemia | qPCR, FISH etc. | blood | differential expression | N/A | Leu1 and Leu2 genes are strong candidates as tumor suppressor gene(s) involved in B-CLL leukemogenesis. | 9395242 | LncRNADisease Lnc2Cancer |
| EL0344 | DLEU2 | chronic lymphocytic leukemia | qPCR, Western blot, Northern blot, Luciferase reporter assay etc. | blood, cell lines (HEK293, U2OS etc.) | down-regulated | expression | The microRNAs miR-15a and miR-16-1 are downregulated in multiple tumor types and are frequently deleted in chronic lymphocytic leukemia (CLL), myeloma and mantle cell lymphoma. DLEU2 negatively regulates the G1 Cyclins E1 and D1 through miR-15a/miR-16-1 and provide evidence that these oncoproteins are subject to miR-15a/miR-16-1-mediated repression under normal conditions. We also demonstrate that DLEU2 overexpression blocks cellular proliferation and inhibits the colony-forming ability of tumor cell lines in a miR-15a/miR-16-1-dependent way. | 19591824 | LncRNADisease Lnc2Cancer |
| EL0877 | MIR155HG | chronic lymphocytic leukemia | N/A | N/A | N/A | Interaction | MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia. | 21296997 | LncRNADisease |
| EL0973 | NEAT1 | chronic lymphocytic leukemia | qPCR, Western blot, knockdown etc. | blood | up-regulated | expression | NEAT1 expression levels were validated by qPCR, demonstrating high baseline expression (average Cp = 21.3), and confirming p53-dependent induction .lncRNAs NEAT1 and lincRNA-p21 as novel elements of the p53-dependent DNA damage response machinery in CLL and lymphoma. | 25971364 | Lnc2Cancer |
| EL1349 | TP53COR1 | chronic lymphocytic leukemia | qPCR etc. | blood (plasma) | down-regulated | expression | HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients. | 24583225 | LncRNADisease Lnc2Cancer |
| EL1349 | TP53COR1 | chronic lymphocytic leukemia | qPCR, Western blot, knockdown etc. | blood | up-regulated | expression | We analyzed its expression in CLL and lymphoma in the context of DNA damage. 24 hours after IR, lincRNA-p21 expression was strongly induced in a p53-dependent manner in a very large set of CLL patients (n = 73).lncRNAs NEAT1 and lincRNA-p21 as novel elements of the p53-dependent DNA damage response machinery in CLL and lymphoma. | 25971364 | Lnc2Cancer |