LncRNA Information
ID EL0343 Name DLEU1 Aliases BCMS; BCMS1; DLB1; DLEU2; LEU1; LEU2; LINC00021; NCRNA00021; XTP6
Species Homo sapiens Chromosome 13 Start site 50082171
End site 50723236 Chain plus Exon NO. 8
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_109974, NR_109973, NR_002605
Ensembl ENSG00000176124 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
B cell chronic lymphocytic leukemia a combination of genomic and cDNA library screening, RT-PCR, Northern blotting N/A N/A N/A As no mutations have been detected for leu1 or any other transcript so far described, we cannot exclude the existence of control elements within the rmd that may regulate expression of genes lying in this region. 12094250
chronic lymphocytic leukemia chromatin-immunoprecipitation (ChIP) that are associated with activated transcription; semi-quantitative and quantitative methods (aPRIMES, BioCOBRA, MCIp, MassARRAY, and bisulfite sequencing) CLL cells N/A N/A the tumor suppressor mechanism at 13q14.3 is a cluster of genes controlled by two lncRNA 23593011
multiple myeloma FISH myeloma cases N/A locus A cdr of approximately 350 kb was identified at 13q14 with the proximal border approximately 120 kb centromeric from d13s319, encompassing an area rich in expressed sequence tagged sites and containing dleu1, dleu2, and rfp2 genes. 12461754
breast cancer microarray, qRT-PCR MCF-7 (ER-positive) and MDA-MB-231 cells (ER- negative) up-regulated interaction MiR-19a might be co-expressed with lncRNA-DLEU1 to co-regulate the expression of ESR1, which influences the occurrence and development of breast cancer cells with different levels of ER expression. 26416600
head and neck squamous-cell carcinoma microsatellite repeat polymorphisms and PCR N/A N/A locus Multiplexed pcr revealed homozygous deletion of leu1 in one oral cavity tumor. 10684931
B-cell chronic lymphocytic leukemia N/A N/A N/A expression Sequence analysis of the rna variants suggests that bcms transcripts belong to the group of non-coding rnas. 11406609
B-cell chronic lymphocytic leukemia N/A N/A N/A expression Since their putative involvement in b-cll was controversial, our present study provide support for reconsidering the dleu1 and dleu2 genes as b-cll candidate genes 11691637
inherited bone marrow failure disorder oligonucleotide microarray N/A up-regulated expression several oncogenes were found to be upregulated, including LARG, TAL1 and MLL, and of several tumour suppressor genes were downregulated, including DLEU1, RUNX1, FANCD2 and DKC1. Real time polymerase chain reaction confirmed statistically higher expression of LARG and TAL1 in SDS marrows. 17539775
chronic lymphocytic leukemia qPCR etc. blood differential expression locus In 13q14.3, where several tumor suppressor genes, including the miRNA genes miR-16-1 and miR-15a, are co-regulated by the two long non-coding RNA genes DLEU1 and DLEU2 that span the critical region. 19347735 LncRNADisease Lnc2Cancer
chronic lymphocytic leukemia qPCR, FISH etc. blood down-regulated mutation Frequently deleted in B-cell chronic lymphocytic leukemia. 11161783 LncRNADisease Lnc2Cancer
chronic lymphocytic leukemia qPCR, FISH etc. blood differential expression N/A Leu1 and Leu2 genes are strong candidates as tumor suppressor gene(s) involved in B-CLL leukemogenesis. 9395242 LncRNADisease Lnc2Cancer
 


Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
N/A N/A N/A expression The nondeleted allele of the car and est70/leu1 genes was expressed in b-cll specimens, including those with monoallelic loss 11264177
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
ESR1 RNA-Protein co-expression A statistical analysis revealed that there was a co-expression relationship between ESR1 and lncRNA-DLEU1. 26416600
MiR-19a RNA-RNA co-expression MiR-19a might be co-expressed with lncRNA-DLEU1 to co-regulate the expression of ESR1, which influences the occurrence and development of breast cancer cells with different levels of ER expression. 26416600