Related LncRNAs |
ID |
lncRNA Name |
Disease |
Method |
Sample |
Expression pattern |
Dysfunction type |
Description |
PMID |
Source |
EL0289 |
CDKN2B-AS1 |
atherosclerosis |
N/A |
N/A |
N/A |
mutation |
Genotypes of rs10757278 linked to increased risk of atherosclerotic diseases are also associated with decreased expression in PBTL of the INK4/ARF locus, near CDKN2B-AS1 locus. |
19343170 |
LncRNADisease
|
EL0289 |
CDKN2B-AS1 |
atherosclerosis |
N/A |
N/A |
N/A |
expression |
9p21.3 may promote atherosclerosis by regulating expression of ANRIL, which in turn is associated with altered expression of genes controlling cellular proliferation pathways. |
19592466 |
LncRNADisease
|
EL0289 |
CDKN2B-AS1 |
atherosclerosis |
N/A |
N/A |
N/A |
mutation/expression |
Transcripts EU741058 and NR_003529 of antisense noncoding RNA in the INK4 locus (ANRIL) were significantly increased in carriers of the risk haplotype. |
20056914 |
LncRNADisease
|
EL0289 |
CDKN2B-AS1 |
atherosclerosis |
N/A |
N/A |
N/A |
Interaction |
ANRIL abundantly expressed in atherosclerotic lesions. ANRIL DQ485454 which is not genetically determined by the 9p21 genotype was significantly correlated with MTAP expression. |
20637465 |
LncRNADisease
|
EL0289 |
CDKN2B-AS1 |
atherosclerosis |
N/A |
N/A |
N/A |
locus |
A genetic susceptibility locus. |
20956613 |
LncRNADisease
|
EL0289 |
CDKN2B-AS1 |
atherosclerosis |
N/A |
N/A |
N/A |
mutation |
Individuals homozygous for the atherosclerotic risk allele (rs3217992, A>G;rs1063192, C>T) show decreased expression of ANRIL. |
21151960 |
LncRNADisease
|
EL0289 |
CDKN2B-AS1 |
atherosclerosis |
N/A |
N/A |
N/A |
expression |
Gene expression studies have found that expression levels of CDKN2A/CDKN2B/ANRIL are co-regulated and associated with the risk haplotype and atherosclerosis severity. |
21550161 |
LncRNADisease
|
EL0289 |
CDKN2B-AS1 |
atherosclerosis |
N/A |
N/A |
N/A |
mutation |
The risk alleles for atherosclerosis-related phenotypes were consistently associated with a lower expression of ANRIL when evaluating exons 1-2. Common carotid artery stenosis was associated with a significantly lower (P<0.01) expression of ANRIL (exons 1-2). ANRIL knock-down in VSMC caused significant variation in expression of CDKN2A/B (P<0.05) and reduction of cell growth (P<0.05) in vitro. |
22178423 |
LncRNADisease
|
EL0289 |
CDKN2B-AS1 |
atherosclerosis |
N/A |
N/A |
N/A |
mutation |
Genetic variation in lncRNA genes causes disease and influences susceptibility |
23791884 |
LncRNADisease
|
EL0289 |
CDKN2B-AS1 |
atherosclerosis |
N/A |
N/A |
N/A |
regulation |
The large non-coding RNA ANRIL, which is associated with atherosclerosis, periodontitis and several forms of cancer, regulates ADIPOR1, VAMP3 and C11ORF10. |
23813974 |
LncRNADisease
|
EL0289 |
CDKN2B-AS1 |
atherosclerosis |
N/A |
N/A |
N/A |
mutation |
Chr9p21 encodes the long non-coding RNA (ncRNA) antisense non-coding RNA in the INK4 locus (ANRIL). ANRIL expression is associated with the Chr9p21 genotype and correlated with atherosclerosis severity |
23861667 |
LncRNADisease
|
EL0556 |
H19 |
atherosclerosis |
N/A |
N/A |
N/A |
epigenetics |
The most pronounced differences of atherosclerotic plaques in DNA methylation levels were registered for a site which is located in CpG-island of imprinted gene H19. |
21954592 |
LncRNADisease
|
EL0600 |
HULC |
atherosclerosis |
N/A |
liver cancer |
up-regulated |
N/A |
HULC regulated TNF-α-induced apoptosis through regulation of miR-9 expression |
26981838 |
|
EL1166 |
RP5-833A20.1 |
atherosclerosis |
N/A |
N/A |
N/A |
N/A |
Using microarray analysis, the authors found that long noncoding RNA RP5-833A20.1 expression was upregulated, whereas nuclear factor IA (NFIA) expression was downregulated in human acute monocytic leukemia macrophage-derived foam cells. Moreover, they showed that long noncoding RNA RP5-833A20.1 maydecreases NFIA expression by inducing hsa-miR-382-5p expression in vitro. |
25265644 |
LncRNADisease
|
EL1349 |
TP53COR1 |
atherosclerosis |
N/A |
N/A |
N/A |
N/A |
The expression of lincRNA-p21 was dramatically downregulated in atherosclerotic plaques of ApoE(-/-) mice, an animal model for atherosclerosis. LincRNA-p21 represses cell proliferation and induces apoptosis in vascular smooth muscle cells and mouse mononuclear macrophage cells in vitro |
25156994 |
LncRNADisease
|
|