| Disease |
| Disease |
Drug/chemo/stress |
Method |
Sample |
Expression pattern |
Dysfunction type |
Description |
PMID |
| AIDS |
|
N/A |
N/A |
N/A |
expression |
HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP. |
20471949 |
| AIDS |
|
N/A |
N/A |
N/A |
expression |
Tat efficiently replaces HEXIM1 on the 7SK snRNA in vivo and therefore, it promotes the disassembly of the 7SK/HEXIM/P-TEFb negative transcriptional regulatory snRNP to augment the nuclear level of active P-TEFb. The human 7SK snRNA carries a TAR RNA-like Tat-binding element that is essential for the normal transcriptional regulatory function of 7SK questions the viability of HIV therapeutic approaches based on small drugs blocking the Tat-binding site of HIV TAR. |
20976203 |
| AIDS |
|
N/A |
N/A |
N/A |
expression |
The 7SK-HMGA1 interaction not only adds an essential facet to the comprehension of transcriptional plasticity at the coupling of initiation and elongation, but also might provide a molecular link between HIV reprogramming of cellular gene expression-associated oncogenesis. |
21087998 |
| AIDS |
|
N/A |
N/A |
N/A |
expression |
Stable expression of cdNIPP1 increased CDK9 phosphorylation on Thr(186) and the association of CDK9 with 7SK RNA. The stable expression of cdNIPP1 disrupted the interaction of Tat and PP1 and inhibited HIV-1 transcription. Expression of cdNIPP1 as a part of the HIV-1 genome inhibited HIV-1 replication. |
21098020 |
| AIDS |
|
N/A |
N/A |
N/A |
expression |
The HIV-1 Tat protein also releases P-TEFb from the 7SK/HEXIM complex during viral infection to promote viral transcription and replication. |
22377309 |
| cancer |
|
N/A |
N/A |
N/A |
expression |
Together with the HEXIM proteins, 7SK RNA associates with and sequesters a fraction of cellular P-TEFb into a catalytically inactive complex. Active and inactive forms of P-TEFb are kept in a functional and dynamic equilibrium tightly linked to the transcriptional requirement of the cell. Importantly, cardiac hypertrophy and development of various types of human malignancies have been associated with increased P-TEFb activity, consequence of a disruption of this regulatory equilibrium. |
22377309 |
| cardiac hypertrophy |
|
N/A |
N/A |
N/A |
expression |
Together with the HEXIM proteins, 7SK RNA associates with and sequesters a fraction of cellular P-TEFb into a catalytically inactive complex. Active and inactive forms of P-TEFb are kept in a functional and dynamic equilibrium tightly linked to the transcriptional requirement of the cell. Importantly, cardiac hypertrophy and development of various types of human malignancies have been associated with increased P-TEFb activity, consequence of a disruption of this regulatory equilibrium. |
22377309 |
| gastric cancer |
|
N/A |
N/A |
N/A |
expression |
Transfection of an siRNA directed against LARP7 (anti-LARP7 siRNA) into non-neoplastic gastric epithelial cells decreased 7sk levels by 72% relative to a control siRNA (P<0.01). |
22488152 |
| Function (not disease relevant) |
| Drug/chemo/stress |
Methods |
Sample/condition |
Expression pattern |
Dysfunction type |
Description |
PMID |
|
NMR |
|
|
interaction |
The xRRM is general to the LARP7 family of proteins and defines the binding site for hLARP7 on the 7SK RNA, providing insight into function. |
27679474 |
|
|
|
differential expression |
interaction |
7SK recognition and assembly of the core 7SK RNP. |
29946027 |
|
Immunoprecipitation,Immunofluorescence microscopy,FISH, |
HeLa cell |
N/A |
expression |
N/A |
17381310 |
|
N/A |
N/A |
N/A |
expression |
The transcription-dependent interaction of p-tefb with 7sk may therefore contribute to an important feedback loop modulating the activity of rna pol ii. |
11713533 |
|
N/A |
N/A |
N/A |
expression |
The 7sk/p-tefb interaction may serve as a principal control point for the induction of cellular and hiv-1 viral gene expression during stress-related responses. |
11713532 |
|
RNA-seq, qRT-PCR |
three different brain regions (cortex, white matter, and cerebellum) of human postmortem tissue |
N/A |
N/A |
Thus, these 5 lncRNAs may be applicable as references for accurate normalisation of lncRNA profiling in multiple brain regions during long PMI, enabling the generation of highly reproducible datasets in lncRNA studies of the human brain. |
25528156 |
|
|
|
|
expression |
By binding to the HEXIM protein, the complex comprising proteins LARP7 and MePCE captures the positive transcription elongation factor P-TEFb and prevents phosphorylation of pausing factors. |
28082395 |
