| Disease |
| Disease |
Drug/chemo/stress |
Method |
Sample |
Expression pattern |
Dysfunction type |
Description |
PMID |
| permanent middle cerebral artery occlusion |
|
Luciferase reporter assay |
human umbilical veendothelial cells |
|
interaction |
Luciferase reporter assay indicated that HIF1A-AS2 serves as a 'sponge' to miR-153-3p, which decreased the post-transcriptional silencing of HIF-1α by miR-153-3p. This function of HIF1A-AS2 facilitated the activation of HIF-1α/VEGFA/Notch1 cascades, by which HUVECs viability, migration ability and tube formation were promoted. These results suggest an enhanced angiogenesis in HUVECs |
28984197 |
| colorectal cancer |
|
qRT-PCR |
CRC tissues and cells |
|
interaction |
HIF1A-AS2 could directly bind with miR-129-5p, and could positively affect cell proliferation, invasion and EMT formation by regulation of the expression of miR-129-5p and DNMT3A |
29278853 |
| breast cancer |
|
qRT-PCR, western blot, luciferase reporter assay, immunohistochemistry assays, knockdown, overexpression |
MDA-MB-231, MCF-7, ZR-75-1, and BT-549 BC cell lines. |
up-regulated |
interaction |
The inhibitive effect of sh-HIF1A-AS2 on the proliferation, invasion, and pathological damage of breast cancer via targeting miR-548c-3p through regulating HIF-1α/VEGF pathway in vitro and vivo. |
30774370 |
| osteosarcoma |
|
overexpression |
OS tissues and cells, xenotransplantation Tumor mouse model |
up-regulated |
interaction |
Long noncoding RNA HIF1A-AS2 facilitates cell survival and migration by sponging miR-33b-5p to modulate SIRT6 expression in osteosarcoma. |
31626739 |
| osteosarcoma |
|
qRT-PCR,overexpression,Luciferase reporter assays |
osteosarcoma cell lines |
up-regulated |
interaction |
LncRNA HIF1A-AS2 promotes osteosarcoma progression by acting as a sponge of miR-129-5p. |
31866584 |
| renal cancer |
|
qRT-PCR |
renal cancer tissue |
up-regulated |
expression |
overexpressed in human renal cancer and during hypoxia. |
9923855 |
| osteosarcoma |
|
microarray, qRt-PCR |
primary osteosarcoma tissue |
up-regulated |
N/A |
The results demonstrated that ASLNC21868, ASLNC22124, ASLNC23844, ASLNC24587, BE503655 and BC050642 were over-regulated and that ASLNC00339, ASLNC11435, ASLNC13387 and ASLNC18814 were under-regulated in the osteosarcoma samples compared with normal samples. The qPCR results and microarray data are consistent. |
23466354 |
| kidney cancer |
|
N/A |
N/A |
N/A |
expression |
Diagnostic and discriminative marker |
24373479 |
| acute myocardial infarction |
|
N/A |
N/A |
N/A |
N/A |
Level of hypoxia inducible factor 1A antisense RNA 2 was higher in patients with MI than in healthy volunteers (P<0.01) |
25035150 |
| gastric cancer |
|
qRT-PCR |
cancerous gastric tissue, blood (serum) |
up-regulated |
expression |
The expression of HIF1A-AS2 was upregulated in GC tumorous tissues compared with the adjacent normal tissues (P < 0.001). Its overexpression was correlated with TNM stages (P = 0.008), tumor invasion (P = 0.016), lymph node metastasis (P = 0.042), and poor prognosis (P = 0.001). |
25686741 |
| bladder cancer |
|
|
bladder cancer tissue and cells |
up-regulated |
N/A |
Overexpression of HIF1A-AS2 in SV-HUC-1 cells could promote cell proliferation cell migration and anti-apoptosis |
27018306 |
| glioblastoma multiforme |
|
|
Mesenchymal Glioblastoma Stem-like Cells |
up-regulated |
expression |
HIF1A-AS2 contributes to GSCs' speciation and adaptation to hypoxia within the tumor microenvironment, acting directly through its interactome and targets and indirectly by modulating responses to hypoxic stress depending on the subtype-specific genetic context. |
27264189 |
| hepatocellular carcinoma |
|
qRT-PCR |
liver specimens obtained from well-characterized patients with HBV-, hepatitis C virus (HCV)-, or hepatitis D virus (HDV)-associated HCC |
down-regulated |
expression |
Some of these lncRNAs were significantly dysregulated predominantly in one specific hepatitis virus-related HCC, including PCAT-29 in HBV-related HCC, aHIF and PAR5 in HCV-related HCC, and Y3 in HDV-related HCC. |
27894309 |
| bladder cancer |
cisplatin |
Knockdown |
bladder cancer cells and tissue after cisplat(Cis) treatment. |
up-regulated |
expression |
The long noncoding RNA HIF1A-AS2 facilitates cisplatin resistance in bladder cancer. |
30216500 |
| glioblastoma |
radioresistance |
overexpression,knockdown |
GBM cancerous tissues, as well as in radioresistant GBM cells. |
up-regulated |
expression |
AHIF promotes glioblastoma progression and radioresistance via exosomes. |
30387845 |
| triple-negative breast cancer |
|
|
TNBC tissues compared with non-TNBC tissues or adjacent normal tissues |
up-regulated |
expression |
HIF1A-AS2 predicts poor prognosis and regulates cell migration and invasion in triple-negative breast cancer. |
30635931 |
| endometriosis |
|
|
human umbilical veendothelial cells (HUVECs) |
up-regulated |
expression |
The Exosomal Long Noncoding RNA aHIF is Upregulated in Serum From Patients With Endometriosis and Promotes Angiogenesis in Endometriosis. |
30808247 |
| epithelial ovarian cancer |
|
qRT-PCR,overexpression |
EOC patients |
up-regulated |
expression |
The expression of serum exosomal aHIF was higher in EOC patients and was correlated with the aHIF level in EOC tissues. |
31571921 |
| myocardial infarction |
hypoxia |
Knockdown, Overexpression, qRT-PCR, western blot, Luciferase reporter assay, RNA pull-down, RIP, Northern blot, |
Human cardiomyocyte primary cells |
up-regulated |
expression |
Cardiomyocytes can be protected against hypoxic-treated injury by knockdown of HIF1A-AS2, which suppresses TRIM44, and that HIF1A-AS2 Overexpression is a prognostic indicator of MI. |
32222118 |