LncRNA Information
ID EL1217 Name HEIH Aliases HCCAT2, LINC-HEIH, LINC00848, lncRNA-HEIH
Species Homo sapiens Chromosome 5 Start site 180829954
End site 180831618 Chain minus Exon NO. 1
Assembly GRCh38.p13 Class lncRNA NCBI accession NR_045680
Ensembl ENSG00000278970 Sequence NR_045680 Peptide-related N/A
CircRNA N/A Exosomal yes Structure N/A


Disease
Disease Drug/chemo/stress Method Sample Expression pattern Dysfunction type Description PMID
melanoma qRT-PCR,Knockdown The human epidermal melanocyte HEMa-LP, The melanoma cell lines SK-MEL-28, A375, A2058 and SK-MEL-2, up-regulated interaction LncRNA-HEIH as a key oncogene in melanoma via transcriptional inhibition of miR-200b/a/429. 28487474
colorectal cancer qRT-PCR, luciferase reporter assays CRC tissues and cell lines up-regulated interaction This study demonstrated that lncRNA-HEIH promotes CRC tumorigenesis through counteracting miR-939‒mediated transcriptional repression of Bcl-xL 29081216
triple-negative breast cancer overexpression TNBC tissues and cell lines, adjacent normal mammary tissues, normal mammary epithelial cell line up-regulated interaction LncRNA HEIH regulates cell proliferation and apoptosis through miR-4458/SOCS1 axis in triple-negative breast cancer. 31456112
cholangiocarcinoma knockdown, luciferase reporter assay, qRT-PCR, RIP CHOL tissues and cells up-regulated interaction HEIH promoted CHOL tumorigenesis and progression by miR-98-5p/HECTD4 axis, which opens up a new insight for CHOL therapeutics. 32062383
hepatocellular carcinoma microarray, qRT-PCR, RIP, RNA pulldown HCC tissue, cell lines (Huh7, HepG2) up-regulated N/A The transcript levels of lncRNA-HEIH were higher in HCC tissues (p=0.010) when compared with the corresponding non-tumor liver tissues from the same donor. And we found that patients with high lncRNA-HEIH expression in HCC had significantly worse prognosis than those with low lncRNA-HEIH expression. 21769904
hepatocellular carcinoma N/A N/A N/A expression Dr. Yang and his colleagues found that one lncRNA, named lncRNA-HEIH, was overexpressed in HCC tissue compared with normal liver tissues using microarray. 24757675
hepatocellular carcinoma qRT-PCR, western blot, knockdown cell lines (MHCC97L, HepG2, cHL-7702) up-regulated expression The expression of HEIH and HULC in hepatocellular carcinoma cell line was significantly increased compared with human normal hepatocyte line (P<0.05). The expression of HULC in HepG2 was higher than that in MHCC97L. The over-expression of HULC could enhance proliferation of MHCC97L and HepG2, however, the over-expression of HEIH could not. The over-expression of HULC and HEIH could promote invasion of MHCC97L and HepG2. Invasion of MHCC97L and HepG2 did not have significant change after down-regulating of HEIH and HULC by siRNA. Over-expression of HULC up-regulated the expression of Snail in HepG2. 26550214
hepatocellular carcinoma qRT-PCR serum and exosomes expression LncRNA-HEIH expression in serum and exosomes was increased, but the ratio of lncRNA-HEIH expression in serum versus exosomes was decreased compared to patients with CHC 29286922
hepatocellular carcinoma (HCC) exosomes derived from CSCs and mesenchymal stem cells (MSCs) up-regulated expression CSCs-exosomes also elevated HCC exosomal microRNA (miR) 21, exosomal long noncoding (lnc) RNA Tuc339, lncHEIH, and the HCC lncHOTAIR and decreased liver miR122 and HCC miRs (miR148a, miR16, and miR125b). 30224923
non-small cell lung cancer qRT-PCR, gain- and loss-of-function, western blot, overexpression human NSCLC lines and tissues up-regulated expression HEIH could accelerate the proliferation and metastasis of NSCLC, providing a novel therapeutic target for clinical treatment. 30230600
epithelial ovarian cancer microarray, qRT-PCR, knockdown a normal ovary cell line, and two ovarian carcinoma cell lines (SKOV3 and SKOV3/DDP) up-regulated expression knockdown experiments confirmed that suppression of HEIH expression inhibited EOC cell proliferation. 31098301
endometrial cancer Paclitaxel qRT-PCR,western blot,knockdown,overexpression endometrial cancer tissues, human healthy tissues up-regulated expression Down-regulating lncRNA HEIH expression reversed the PTX-resistance of endometrial cancer cells through MAPK signaling pathway. 31650338


Function (not disease relevant)
Drug/chemo/stress Methods Sample/condition Expression pattern Dysfunction type Description PMID
sofosbuvir, daclatasvir, ribavirin qRT-PCR serum down-regulated expression mRNA BST2 and LncRNA HEIH were downregulated in naïve patients. 31988583


Interaction
Interaction target Level of interaction Type of interaction Methods Description PMID
miR-1253 RNA-RNA binding luciferase reporter assay, RIP RIP assay and luciferase assay verified the ceRNA network among HEIH, miR-98-5p and HECTD4. 32062383
miR-200a RNA-RNA binding N/A LncRNA-HEIH directly binds to miR-200b/a/429 promoter and represses miR-200b/a/429 transcription. 28487474
miR-200b RNA-RNA binding N/A LncRNA-HEIH directly binds to miR-200b/a/429 promoter and represses miR-200b/a/429 transcription. 28487474
miR-429 RNA-RNA binding N/A LncRNA-HEIH directly binds to miR-200b/a/429 promoter and represses miR-200b/a/429 transcription. 28487474
miR-4458 RNA-RNA binding N/A HEIH directly binds to miR-4458, and negatively regulates miR-4458 expression in TNBC cells 31456112
miR-939 RNA-RNA binding N/A The interaction between lncRNA-HEIH and miR-939 damages the binding between miR-939 and nuclear factor κB (NF-κB), increases the binding of NF-κB to Bcl-xL promoter, and promotes the transcription and expression of Bcl-xL. 29081216
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