Disease |
Disease |
Drug/chemo/stress |
Method |
Sample |
Expression pattern |
Dysfunction type |
Description |
PMID |
melanoma |
|
qRT-PCR,Knockdown |
The human epidermal melanocyte HEMa-LP, The melanoma cell lines SK-MEL-28, A375, A2058 and SK-MEL-2, |
up-regulated |
interaction |
LncRNA-HEIH as a key oncogene in melanoma via transcriptional inhibition of miR-200b/a/429. |
28487474 |
colorectal cancer |
|
qRT-PCR, luciferase reporter assays |
CRC tissues and cell lines |
up-regulated |
interaction |
This study demonstrated that lncRNA-HEIH promotes CRC tumorigenesis through counteracting miR-939‒mediated transcriptional repression of Bcl-xL |
29081216 |
triple-negative breast cancer |
|
overexpression |
TNBC tissues and cell lines, adjacent normal mammary tissues, normal mammary epithelial cell line |
up-regulated |
interaction |
LncRNA HEIH regulates cell proliferation and apoptosis through miR-4458/SOCS1 axis in triple-negative breast cancer. |
31456112 |
cholangiocarcinoma |
|
knockdown, luciferase reporter assay, qRT-PCR, RIP |
CHOL tissues and cells |
up-regulated |
interaction |
HEIH promoted CHOL tumorigenesis and progression by miR-98-5p/HECTD4 axis, which opens up a new insight for CHOL therapeutics. |
32062383 |
hepatocellular carcinoma |
|
microarray, qRT-PCR, RIP, RNA pulldown |
HCC tissue, cell lines (Huh7, HepG2) |
up-regulated |
N/A |
The transcript levels of lncRNA-HEIH were higher in HCC tissues (p=0.010) when compared with the corresponding non-tumor liver tissues from the same donor. And we found that patients with high lncRNA-HEIH expression in HCC had significantly worse prognosis than those with low lncRNA-HEIH expression. |
21769904 |
hepatocellular carcinoma |
|
N/A |
N/A |
N/A |
expression |
Dr. Yang and his colleagues found that one lncRNA, named lncRNA-HEIH, was overexpressed in HCC tissue compared with normal liver tissues using microarray. |
24757675 |
hepatocellular carcinoma |
|
qRT-PCR, western blot, knockdown |
cell lines (MHCC97L, HepG2, cHL-7702) |
up-regulated |
expression |
The expression of HEIH and HULC in hepatocellular carcinoma cell line was significantly increased compared with human normal hepatocyte line (P<0.05). The expression of HULC in HepG2 was higher than that in MHCC97L. The over-expression of HULC could enhance proliferation of MHCC97L and HepG2, however, the over-expression of HEIH could not. The over-expression of HULC and HEIH could promote invasion of MHCC97L and HepG2. Invasion of MHCC97L and HepG2 did not have significant change after down-regulating of HEIH and HULC by siRNA. Over-expression of HULC up-regulated the expression of Snail in HepG2. |
26550214 |
hepatocellular carcinoma |
|
qRT-PCR |
serum and exosomes |
|
expression |
LncRNA-HEIH expression in serum and exosomes was increased, but the ratio of lncRNA-HEIH expression in serum versus exosomes was decreased compared to patients with CHC |
29286922 |
hepatocellular carcinoma (HCC) |
|
|
exosomes derived from CSCs and mesenchymal stem cells (MSCs) |
up-regulated |
expression |
CSCs-exosomes also elevated HCC exosomal microRNA (miR) 21, exosomal long noncoding (lnc) RNA Tuc339, lncHEIH, and the HCC lncHOTAIR and decreased liver miR122 and HCC miRs (miR148a, miR16, and miR125b). |
30224923 |
non-small cell lung cancer |
|
qRT-PCR, gain- and loss-of-function, western blot, overexpression |
human NSCLC lines and tissues |
up-regulated |
expression |
HEIH could accelerate the proliferation and metastasis of NSCLC, providing a novel therapeutic target for clinical treatment. |
30230600 |
epithelial ovarian cancer |
|
microarray, qRT-PCR, knockdown |
a normal ovary cell line, and two ovarian carcinoma cell lines (SKOV3 and SKOV3/DDP) |
up-regulated |
expression |
knockdown experiments confirmed that suppression of HEIH expression inhibited EOC cell proliferation. |
31098301 |
endometrial cancer |
Paclitaxel |
qRT-PCR,western blot,knockdown,overexpression |
endometrial cancer tissues, human healthy tissues |
up-regulated |
expression |
Down-regulating lncRNA HEIH expression reversed the PTX-resistance of endometrial cancer cells through MAPK signaling pathway. |
31650338 |