LncRNA Information | |||||
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ID | EL1138 | Name | Gm37494 | Aliases | N/A |
Species | Homo sapiens | Chromosome | N/A | Start site | N/A |
End site | N/A | Chain | N/A | Exon NO. | N/A |
Assembly | N/A | Class | lncRNA | NCBI accession | N/A |
Ensembl | N/A | Sequence | N/A | Peptide-related | N/A |
CircRNA | N/A | Exosomal | yes | Structure | N/A |
Disease | |||||||||
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Disease | Drug/chemo/stress | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | ||
spinal cord injury | qRT-PCR, western blot, RNA-seq, Luciferase reporter assays, ELISA, Knockdown, Overexpression, immunofluorescence | C57BL/6 mice, ADSC cells, BV2 microglial cell line | up-regulated | interaction | HExos repair SCI by delivering lncGm37494, advising that lncGm3749 functions importantly in microenvironmental regulation and shows possibility for SCI treatments. | 32307615 |
Interaction | |||||||||
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Interaction target | Level of interaction | Type of interaction | Methods | Description | PMID | ||||
miR-130b-3p | RNA-RNA | regulation | western blot, ELISA | LncGm37494 expression was significantly higher in HExos than Exos, and its upregulation promoted microglial M1/M2 polarization by inhibiting miR-130b-3p and promoting PP ARγ expression, as shown by luciferase reporter experiments. | 32307615 | ||||
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