LncRNA Information
ID EL0630 Name CCND1 Aliases BCL1, D11S287E, PRAD1, U21B31
Species Homo sapiens Chromosome 11 Start site 69641156
End site 69654474 Chain plus Exon NO. 5
Assembly GRCh38.p13 Class retained intron NCBI accession N/A
Ensembl N/A Sequence N/A Peptide-related N/A
CircRNA N/A Exosomal yes Structure N/A


Disease
Disease Drug/chemo/stress Method Sample Expression pattern Dysfunction type Description PMID
cervical cancer qRT-PCR cell line (CaSki) up-regulated N/A Generally, we found that some of the RNA molecules (HOTAIR and MALAT1) are down-regulated while many of them (lincRNA-p21, GAS5, MEG3, ANRIL, and ncRNA-CCND1) are up-regulated and some others (TUG1, UCA1, and PANDA) not affected. The decline in the expression of HOTAIR and MALAT1 was clearly evident in BLM-treated HeLa and MCF cells. For lincRNA-p21, ncRNA-CCND1, and MEG3, a similar up-regulation pattern was obvious in both cell lines where the increase was generally more pronounced in BLM-treated cells. 22487937
tumor N/A N/A N/A expression Binding to TLS protein induces TLS allosteric change, allowing interaction with cyclin D1, inhibiting CBP and p300 activity, and silencing cyclin D1 gene expression. 22996375


Function (not disease relevant)
Drug/chemo/stress Methods Sample/condition Expression pattern Dysfunction type Description PMID
exosomes secreted from cultured cells up-regulated expression lincRNA-p21 and ncRNA-CCND1 were the main molecules; exosome levels of them best reflect the change of their cellular levels upon exposure of the cells to bleomycin-induced DNA damage. 24798520