| Disease |
| Disease |
Drug/chemo/stress |
Method |
Sample |
Expression pattern |
Dysfunction type |
Description |
PMID |
| osteosarcoma |
|
RNA purification assay |
osteosarcoma tissues |
up-regulated |
interaction |
Functional experiments demonstrated that knockdown of BCAR4 inhibits the proliferation and migration of osteosarcoma cell in vitro.Consistently, knockdown of BCAR4 inhibits osteosarcoma tumorigenesis and lung metastasis in vivo. |
27460090 |
| colorectal cancer |
|
qRT-PCR, western blot, luciferase reporter assay, overexpression, |
colon cancer stem/initiating cells (CSC) , ALDH+ cells |
up-regulated |
interaction |
LncRNA BCAR4, targeting to miR-665/STAT3 signaling, maintains cancer stem cells stemness and promotes tumorigenicity in colorectal cancer. |
30962766 |
| glioma |
|
knockdown, overexpression |
glioma tissues, glioma cells |
up-regulated |
interaction |
Long noncoding RNA BCAR4 promotes glioma cell proliferation via EGFR/PI3K/AKT signaling pathway. |
31173355 |
| glioma |
|
qRT-PCR, western blot, knockdown, Luciferase reporter assays, RNA pull-down, |
graded gliomas Specimens, glioblastoma (GBM) cell lines |
up-regulated |
interaction |
Long Non-Coding RNA BCAR4 Promotes Growth, Invasion and Tumorigenicity by Targeting miR-2276 to Upregulate MMP7 Expression in Glioma |
31849498 |
| bladder cancer |
|
knockdown, |
BC tissues compared with matched healthy tissues. |
up-regulated |
interaction |
lncRNA BCAR4 sponges miR‑370‑3p to promote bladder cancer progression via Wnt signaling. |
31894304 |
| bladder cancer |
|
qRT-PCR, knockdown |
bladder cancer cell lines |
up-regulated |
interaction |
BCAR4 sponged miR-644a to modulate the expression of TLX1 and promote bladder cancer development. |
32273720 |
| liver cancer |
|
knockdown, overexpression |
Huh‑7 cells |
up-regulated |
interaction |
LncRNA BCAR4 may promote liver cancer development by directly binding to miR‑1261 and targeting ANAPC11. |
32319544 |
| breast cancer |
|
qRT-PCR |
cell line (ZR-75-1) |
up-regulated |
N/A |
Breast cancer anti-estrogen resistance 4 (BCAR4), caused OH-TAM resistance and anchorage-independent cell growth in ZR-75-1 cells. |
16778085 |
| breast cancer |
|
qRT-PCR, western blot |
cell lines (ZR-75-1, BCAR3, EGFR etc.) |
up-regulated |
expression |
High BCAR4 mRNA levels were associated with poor MFS and overall survival, reflecting tumour aggressiveness. |
20859285 |
| breast cancer |
|
qRT-PCR |
cell line (ZR-75-1) |
up-regulated |
expression |
BCAR4 is expressed in 27% of primary breast tumors. Forced expression of BCAR4 in human ZR-75-1 and MCF7 breast cancer cells resulted in cell proliferation in the absence of estrogen and in the presence of various antiestrogens.BCAR4 may be a good target for treating antiestrogen-resistant breast cancer. |
21506106 |
| breast cancer |
|
microarray, qRT-PCR, knockdown |
cell lines (ZR-75-1, MCF7, BCAR4 etc.) |
differential expression |
expression |
BCAR4 induces antioestrogen resistance but sensitises breast cancer to lapatinib. |
22892392 |
| breast cancer |
|
N/A |
N/A |
N/A |
N/A |
BCAR4 binding of SNIP1 and PNUTS in response to CCL21 releases the SNIP1's inhibition of p300-dependent histone acetylation, which in turn enables the BCAR4-recruited PNUTS to bind H3K18ac and relieve inhibition of RNA Pol II via activation of the PP1 phosphatase. |
25416949 |
| colorectal
cancer |
|
qRT-PCR |
|
|
expression |
The combination of two mRNAs, KRTAP5-4 and MAGEA3, and one lncRNA, BCAR4, could be potential candidates to detect colorectal cancer. |
27197301 |
| osteosarcoma |
|
qRT-PCR |
osteosarcoma tissues and cell lines, normal controls. |
up-regulated |
expression |
The BCAR4 levels were significantly correlated with clinical stage and distant metastasis. |
27874956 |
| non-small cell lung cancer |
|
qRT-PCR |
NSCLC tissues and their adjacent non-tumor tissues, NSCLC cell lines |
up-regulated |
expression |
The upregulation of lncRNA BCAR4 expression plays a promoting role in the malignant progression of NSCLC |
28077810 |
| chondrosarcoma |
|
qRT-PCR, western blot, overexpression, knockdown |
chondrosarcoma tissues and cells, Chondrosarcoma xenograft mouse model |
up-regulated |
expression |
LncRNA BCAR4 promoted chondrosarcoma cell proliferation and migration through activation of mTOR signaling pathway, and thus contributed to chondrosarcoma progression. |
28399646 |
| non-small cell lung cancer |
|
qRT-PCR, knockdown, western blotting,immunofluorescence assay |
76 pairs of NSCLC tissues and corresponding cancer-adjacent tissues and 6 NSCLC cell lines, Metastatic tumor model of nude mice |
up-regulated |
expression |
BCAR4 promotes the invasion and metastasis of NSCLC via regulating EMT and BCAR4/EMT interaction can be used as a new target for the diagnosis and therapeutics of NSCLC. |
28537678 |
| colon cancer |
|
|
|
|
expression |
LncRNA BCAR4 promotes colon cancer progression via activating Wnt/β-catenin signaling. |
29190958 |
| cervical cancer |
|
qRT-PCR, knockdown, overexpression, |
cervical cancer tissue and cell lines |
up-regulated |
expression |
The results indicated that BCAR4 might play a crucial role in cervical cancer progression and act as an underlying biomarker for the diagnosis and prognosis of cervical cancer. |
29937186 |
| hepatocellular carcinoma |
|
qRT-PCR, |
HCC tissues |
down-regulated |
expression |
Development of a GeXP-Based Multiplex RT-PCR Assay for Detection of Long Noncoding RNA in Hepatocellular Carcinoma. |
30423146 |
| castration-resistant prostate cancer |
|
overexpression |
CRPC, compared to normal prostate tissue |
up-regulated |
expression |
BCAR4 activates GLI2 signaling in prostate cancer to contribute to castration resistance. |
30513511 |
| gastric cancer |
|
qRT-PCR, western blot, overexpression |
GC cell lines and tissues |
up-regulated |
expression |
Over-expression of lncRNA BCAR4 promoted cell proliferation and suppressed cell apoptosis in vitro and promoted tumor formation in vivo. |
32329841 |
| Interaction |
| Interaction target |
Level of interaction |
Type of interaction |
Methods |
Description |
PMID |
| EGFR |
RNA-Protein |
regulation |
N/A |
we uncovered that BCAR4 activated PI3K/AKT signaling pathway in glioma through upregulating EGFR and interacting with it. |
31173355
|
| IL6 |
RNA-DNA |
regulation |
N/A |
BCAR4 physically associates with the promoters of GLI2 target genes RPS3, IL6, MUC5AC, and TGF-β1. |
27460090
|
| miR-1261 |
RNA-RNA |
binding |
N/A |
LncRNA BCAR4 was demonstrated to directly bind to microRNA (miR)‑1261 |
32319544
|
| miR-2276 |
RNA-RNA |
binding |
western blot |
we found that BCAR4 could act as a competing endogenous RNA (ceRNA) by targeting miR-2276 to upregulate MMP7 expression. |
31849498
|
| miR-370-3p |
RNA-RNA |
binding |
N/A |
BCAR4 directly sponged microRNA (miR)‑370‑3p and elevated Wnt7a expression. |
31894304
|
| miR-644a |
RNA-RNA |
binding |
N/A |
Mechanically, we showed that BCAR4 can bind to miR-644a directly and targets TLX1. |
32273720
|
| miR-665 |
RNA-TF |
binding |
western blot, luciferase reporter assay |
MiR-665 was the target of BCAR4 and subsequently activated signal transducers and STAT3 signaling which is an important pathway in cancer stem cells self-renewal. |
30962766
|
| MUC5AC |
RNA-DNA |
regulation |
N/A |
BCAR4 physically associates with the promoters of GLI2 target genes RPS3, IL6, MUC5AC, and TGF-β1. |
27460090
|
| RPS3 |
RNA-DNA |
regulation |
N/A |
BCAR4 physically associates with the promoters of GLI2 target genes RPS3, IL6, MUC5AC, and TGF-β1. |
27460090
|
| TGF-β1 |
RNA-DNA |
regulation |
N/A |
BCAR4 physically associates with the promoters of GLI2 target genes RPS3, IL6, MUC5AC, and TGF-β1. |
27460090
|