LncRNA Information
ID	EL0125	Name	ADAM12	Aliases	ADAM12-OT1, CAR10, MCMP, MCMPMltna, MLTN, MLTNA
Species	Homo sapiens	Chromosome	10	Start site	126012391
End site	126388477	Chain	minus	Exon NO.	27
Assembly	GRCh38.p13	Class	lncRNA	NCBI accession	N/A
Ensembl	ENSG00000148848	Sequence	N/A	Peptide-related	N/A
CircRNA	yes	Exosomal	N/A	Structure	N/A

Disease
Disease	Drug/chemo/stress	Method	Sample	Expression pattern	Dysfunction type	Description	PMID
lung cancer		overexpression, knockdown	Xuanwei patients and control regions	up-regulated	interaction	Knockdown of CAR10 inhibited cell growth in vitro and tumor growth in vivo.	27322209
breast cancer		knockdown,	miR-34a knockout breast tissues	up-regulated	interaction	Adam12 and lnc015192 act as ceRNAs in breast cancer by regulating miR-34a.	30042416
lung adenocarcinoma		overexpression	tumor tissue of patients with LUAD	up-regulated	interaction	Long noncoding RNA CAR10 promotes lung adenocarcinoma metastasis via miR-203/30/SNAI axis.	30617305
cervical cancer		knockdown,	4 cervical cancer tissues and cells	up-regulated	interaction	LncRNA CAR10 Upregulates PDPK1 to Promote Cervical Cancer Development by Sponging miR-125b-5p.	32025520

Interaction
Interaction target	Level of interaction	Type of interaction	Methods	Description	PMID
miR-125b-5p	RNA-RNA	binding	N/A	CAR10 acts as a ceRNA to upregulate the expression of PDPK1 by sponging miR-125b-5p.	32025520
miR-203	RNA-RNA	binding	N/A	CAR10 induced epithelial-to-mesenchymal transition (EMT) by directly binding with miR-30 and miR-203 and then regulating the expression of SNAI1 and SNAI2.	30617305
miR-30	RNA-RNA	binding	N/A	CAR10 induced epithelial-to-mesenchymal transition (EMT) by directly binding with miR-30 and miR-203 and then regulating the expression of SNAI1 and SNAI2.	30617305
miR-34a	RNA-RNA	binding	N/A	Adam12 and lnc015192 promote breast cancer metastasis partly by sponging miR-34a through the ceRNA mechanism.	30042416
YB-1	RNA-Protein	binding	N/A	CAR10 bound and stabilized transcription factor Y-box-binding protein 1 (YB-1), leading to up-regulation of the epidermal growth factor receptor (EGFR) and proliferation of lung cancer cells.	27322209

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