LncRNA Information
ID	EL0030	Name	9530018H14Rik	Aliases	lncRNA-HIT
Species	Mus musculus	Chromosome	6	Start site	N/A
End site	N/A	Chain	N/A	Exon NO.	N/A
Assembly	GRCm38.p6	Class	lncRNA	NCBI accession	AK020562
Ensembl	N/A	Sequence	AK020562	Peptide-related	N/A
CircRNA	N/A	Exosomal	N/A	Structure	N/A

Disease
Disease	Drug/chemo/stress	Method	Sample	Expression pattern	Dysfunction type	Description	PMID
breast cancer		qRT-PCR, Luciferase reporter assay	breast cancer tissue, cell lines(NMuMG, 4T1)	up-regulated	expression	The level of expression of lncRNA-HIT in normal breast tissue was low and gradually increased to invasive carcinoma suggesting lncRNA-HIT may play a role in tumor progression in humans. These data further support the findings demonstrating the involvement of lncRNA-HIT in EMT and invasion as observed in NMuMG and 4T1 cells, and suggest that conserved human lncRNA-HIT could play a pivotal role in breast cancer metastasis.	25605728

Function (not disease relevant)
Drug/chemo/stress	Methods	Sample/condition	Expression pattern	Dysfunction type	Description	PMID
	ChIRP-seq, knockdown, RNA FISH, RIP, qRT-PCR, qChIP	E 11 mouse embryos	up-regulated	interaction	Mechanistically the LncRNA-HIT siRNA treatments impacted pro-chondrogenic gene expression by reducing H3K27ac or p100 activity, confirming that LncRNA-HIT is essential for chondrogenic differentiation in the limb mesenchyme.	26633036
	qRT-PCR, knockdown, in situ hybridization	craniofacial, limb, and genitourinary tissue		expression	These results confirm the efficacy of lncRNA-HIT shRNA allele to knock-down endogenous transcripts in tissue- and cell type specific manner and indicate a requirement for lncRNA-HIT in the development of these tissues.	31838787

Interaction
Interaction target	Level of interaction	Type of interaction	Methods	Description	PMID
CBP	RNA-Protein	binding	ChIRP-seq, knockdown, RNA FISH, RIP, qRT-PCR, qChIP	In the limb mesenchyme, LncRNA-HIT was found to be retained in the nucleus, forming a complex with p100 and CBP.	26633036
p100	RNA-Protein	binding	ChIRP-seq, knockdown, RNA FISH, RIP, qRT-PCR, qChIP	In the limb mesenchyme, LncRNA-HIT was found to be retained in the nucleus, forming a complex with p100 and CBP.	26633036

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