LncRNA Information
ID	EL0027	Name	91H	Aliases	N/A
Species	Homo sapiens	Chromosome	N/A	Start site	N/A
End site	N/A	Chain	N/A	Exon NO.	N/A
Assembly	N/A	Class	lncRNA	NCBI accession	N/A
Ensembl	N/A	Sequence	N/A	Peptide-related	N/A
CircRNA	N/A	Exosomal	N/A	Structure	N/A

Disease
Disease	Drug/chemo/stress	Method	Sample	Expression pattern	Dysfunction type	Description	PMID
breast cancer		knockdown	breast cancer cells	up-regulated	interaction	The long non-coding RNA 91H increases aggressive phenotype of breast cancer cells and up-regulates H19/IGF2 expression through epigenetic modifications.	27780718
hepatocellular carcinoma		qRT-PCR, knockdown, overexpression, ChiP, RIP,	HCC tissues	up-regulated	interaction	Long noncoding RNA 91H overexpression contributes to the growth and metastasis of HCC by epigenetically positively regulating IGF2 expression.	31724285
colorectal cancer		immunoprecipitation, RIP	colorectal cancer	up-regulated	interaction	lncRNA 91H promotes IGF2 expression by interacting with IGF2BP2 which would provide a new strategy in finding potential CRC diagnostic biomarkers and therapeutic targets.	32070145
osteosarcoma		Knockdown	osteosarcoma patients and cell lines compared to healthy controls and normal human bone cell lines	up-regulated	expression	High expression of 91H was significantly correlated with advanced clinical stage, chemotherapy after surgery, and tumor size >5 cm. Furthermore, 91H was an independent prognostic factor for overall survival in osteosarcoma patients after treatments.	27555785
colorectal cancer			CRC patients	differential expression	expression	LncRNA 91H enhancing CRC metastasis by modifying HNRNPK expression might be an early plasma-based biomarker for CRC recurrence or metastasis.	29410604

Interaction
Interaction target	Level of interaction	Type of interaction	Methods	Description	PMID
H19	RNA-DNA	regulation	N/A	91H, through epigenetic modifications, is responsible of the maintenance of H19/IGF2 genomic imprinting allowing the allele-specific expression of H19 and IGF2.	27780718
IGF2BP2	RNA-Protein	binding	RIP	Finally, by RNA pull down and RNA-binding protein immunoprecipitation (RIP) assay, a significant interaction was found between lncRNA 91H and IGF2BP2 which was proved to play an important role in CRC IGF2 expression.	32070145
RBBP5	RNA-Protein	binding	N/A	the binding of RBBP5 to 91H and the binding of RBBP5, activating H3K4me3 mark and repressive H3K27me3 mark to the P3 and P4 promoters of IGF2 gene were studied by RIP and ChIP respectively.	31724285

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