LncRNA Information
ID EL1455 Name WSPAR Aliases LncTCF7; TCONS_00009511
Species Homo sapiens Chromosome 5 Start site 133913677
End site 133917269 Chain plus Exon NO. 3
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_131252
Ensembl ENSG00000249073 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
hepatocelluar carcinoma microarray, qPCR, Northern blot, FISH etc. cell lines (Hep3B, Huh7, and PLC) up-regulated interaction Here, using transcriptome microarray analysis, we identified a long noncoding RNA (lncRNA) termed lncTCF7 that is highly expressed in HCC tumors and liver CSCs. Mechanistically, lncTCF7 recruits the SWI/SNF complex to the promoter of TCF7 to regulate its expression, leading to activation of Wnt signaling. Our data suggest that lncTCF7-mediated Wnt signaling primes liver CSC self-renewal and tumor propagation. 25842979 Lnc2Cancer
hepatocelluar carcinoma qPCR, Western blot, Luciferase reporter assay etc. HCC cell lines (SK-Hep-1, BEL-7402) up-regulated interaction We demonstrate that IL-6 could induce lncTCF7 expression in a time- and dose-dependent manner, and we showed that IL-6 transcriptionally activated the expression of lncTCF7 in HCC cells by activating STAT3, a transcription activator which binds to promoter regions of lncTCF7. Furthermore, knocking-down STAT3 and inhibiting STAT3 activation reduced lncTCF7 expression. Importantly, RNA interference-based attenuation of lncTCF7 prevented IL-6-induced EMT and cell invasion. 26452542 Lnc2Cancer
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
SWI/SNF complex RNA-Protein binding lncTCF7 recruits the SWI/SNF complex to the promoter of TCF7 to regulate its expression 25842979
STAT3 RNA-Protein regulation IL-6 transcriptionally activated the expression of lncTCF7 in HCC cells by activating STAT3. 26452542
STAT3 RNA-Protein binding STAT3, a transcription activator which binds to promoter regions of lncTCF7. 26452542