| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL1435 | Name | UFC1 | Aliases | HSPC155 | |
| Species | Homo sapiens | Chromosome | 1 | Start site | 161152776 | |
| End site | 161158856 | Chain | plus | Exon NO. | 8 | |
| Assembly | Ensembl Release 89 | Class | processed transcript | NCBI accession | N/A | |
| Ensembl | ENSG00000143222 | Sequence | N/A | |||
| Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
| hepatocelluar carcinoma | microarray, qPCR, in vitro knockdown etc. | HCC tissue, cell lines (BEL-7402, SK-Hep1, Huh7, MHCC-97H) | up-regulated | regulation | Levels of the lincRNA-UFC1 were increased in HCC tissues compared with controls, and associated with tumor size, Barcelona Clinic Liver Cancer stage, and patient outcomes. Transgenic expression of the lincRNA-UFC1 in HCC cells promoted their proliferation and cell-cycle progression and inhibited apoptosis, whereas short hairpin RNA knockdown of lincRNA-UFC1 had opposite effetcs. | 25449213 | Lnc2Cancer | ||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| microRNA 34a | RNA-RNA | regulation | The lincRNA-UFC1, a target of microRNA 34a, promotes proliferation and reduces apoptosis in HCC cells to promote growth of xenograft tumors in mice. | 25449213 | |||||