LncRNA Information
ID EL1129 Name RNY1 Aliases HY1; Y1
Species Homo sapiens Chromosome 7 Start site 148987136
End site 148987248 Chain minus Exon NO. 1
Assembly Ensembl Release 89 Class N/A NCBI accession NR_004391
Ensembl ENSG00000201098 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
bladder, cervix, colon, kidney, lung and prostate cancer quantitative RT-PCR,RNA interference human solid tumour,nonmalignant normal tissues up-regulated expression Degradation of hY1 and hY3 RNAs in human cell lines resulted in a significant cytostatic inhibition of cell proliferation. 18283318
 


Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
Specific degradation late-G(1)-phase human cells down-regulated mutation Specific degradation of hY RNAs leads to the inhibition of semiconservative DNA replication in late-G(1)-phase template nuclei. This inhibition is negated by resupplementation of hY RNAs. All four hY RNAs (hY1, hY3, hY4, and hY5) can functionally substitute for each other in this system. Mutagenesis of hY1 RNA showed that the binding site for Ro60 protein, which is required for Ro RNP assembly, is not essential for DNA replication. Degradation of hY1 RNA in asynchronously proliferating HeLa cells by RNA interference reduced the percentages of cells incorporating bromodeoxyuridine in vivo. 16943439
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
DNA,Ro60 protein RNA-DNA binding Mutagenesis of hY1 RNA showed that the binding site for Ro60 protein, which is required for Ro RNP assembly, is not essential for DNA replication. 16943439