LncRNA Information | ||||||
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ID | EL1009 | Name | NR024118 | Aliases | N/A | |
Species | Rattus norvegicus | Chromosome | 20 | Start site | 4485316 | |
End site | 4486671 | Chain | N/A | Exon NO. | 5 | |
Assembly | Rnor_6.0 | Class | N/A | NCBI accession | N/A | |
Ensembl | N/A | Sequence | N/A |
Disease | |||||||||
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Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
rheumatoid arthritis | RT-RCR, overexpression | Severe polyarticular arthritis was induced in Balb/c female mice | N/A | expression | NR024118 overexpression and interference significantly changed SOCS3 expression and NR024118 interference could reverse regulation of shikonin on SOCS3, proinflammatory cytokines, and MMPs expression level in MH7A cells. | 26640499 | |||
Function (not disease relevant) | |||||||||
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Methods | Sample/condition | Expression pattern | Dysfunction type | Description | PMID | Source | |||
lncRNAs array, qPCR | Ang II-treated cardiac fibroblasts | down-regulated | expression | Ang II dynamically regulated the expression of lncRNA-NR024118 and Cdkn1c in cardiac fibroblasts, indicating the potential role of NR024118 in cardiac fibroblasts. | 24817929 | ||||
N/A | dult rat cardiac fibroblasts | down-regulated | expression | Our current studies showed that the decrease of lncRNA-NR024118 and Cdkn1c induced by Ang II is mediated by AT1 receptor-dependent not AT2 receptor-dependent, which is helpful to understand the molecular mechanism of Ang II receptors in adult rat cardiac fibroblasts. | 25979571 | ||||
Interaction | |||||||||
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Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
SOCS3 | RNA-DNA | regulation | NR024118 overexpression and interference significantly changed SOCS3 expression and NR024118 interference could reverse regulation of shikonin on SOCS3, proinflammatory cytokines, and MMPs expression level in MH7A cells. | 26640499 | |||||