LncRNA Information
ID EL0952 Name MYCNUT Aliases MYCNUN; lncUSMycN
Species Homo sapiens Chromosome 2 Start site 15920399
End site 15936017 Chain plus Exon NO. 3
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_125783
Ensembl ENSG00000223850 Sequence

Disease Method Sample Expression pattern Dysfunction type Description PMID Source
neuroblastoma qPCR, knockdown etc. neuroblastoma tissue up-regulated N/A The lncUSMycN gene was coamplified with MYCN in 88 of 341 human neuroblastoma tissues. lncUSMycN RNA bound to the RNA-binding protein NonO, leading to N-Myc RNA upregulation and neuroblastoma cell proliferation. High levels of lncUSMycN and NonO expression in human neuroblastoma tissues independently predicted poor patient prognoses. Treatment with antisense oligonucleotides targeting lncUSMycN in neuroblastoma-bearing mice statistically significantly hindered tumor progression. 24906397 Lnc2Cancer