| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL0775 | Name | lncLGR | Aliases | N/A | |
| Species | Mus musculus | Chromosome | N/A | Start site | N/A | |
| End site | N/A | Chain | N/A | Exon NO. | N/A | |
| Assembly | N/A | Class | N/A | NCBI accession | AK028540 | |
| Ensembl | N/A | Sequence | ||||
| Function (not disease relevant) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Methods | Sample/condition | Expression pattern | Dysfunction type | Description | PMID | Source | |||
| lncLGR knockdown enhances GCK expression | fasted mice | up-regulated | N/A | lncLGR knockdown enhances GCK expression and glycogen storage lncLGR knockdown enhances GCK expression and glycogen storage | 26904944 | ||||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| GCK | RNA-DNA | regulation | lncLGR facilitates the recruitment of hnRNPL to the GCK promoter and suppresses GCK transcription. | 26904944 | |||||
| heterogenous nuclear ribonucleoprotein L (hnRNPL) | RNA-DNA | binding | lncLGR specifically binds to heterogenous nuclear ribonucleoprotein L (hnRNPL), which is further confirmed to be a transcriptional repressor of GCK in vivo. | 26904944 | |||||