| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL0721 | Name | LINC-PINT | Aliases | LincRNA-Pint; MKLN1-AS1; PINT | |
| Species | Homo sapiens | Chromosome | 7 | Start site | 130941760 | |
| End site | 131110176 | Chain | minus | Exon NO. | 17 | |
| Assembly | Ensembl Release 89 | Class | antisense | NCBI accession | NR_110473, NR_110472, NR_034120, NR_109855, NR_109854, NR_109853, NR_015431, NR_109852, NR_109851, N | |
| Ensembl | ENSG00000231721 | Sequence | ||||
| Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
| colorectal cancer | microarray, qPCR, RIP etc. | cell lines (KrasLA2/+, Trp53LSL/LSL, Rosa26-CreERT2 etc.) | down-regulated | N/A | In this study, we have identified and characterized the lincRNA named Pint, abona fidep53 transcriptional target that acts as negative modulator of the p53 response.We found a significant downregulation of PINT in colorectal tumors compared with normal tissue, suggesting a potential role of the lincRNA as a tumor suppressor. Pint binds directly to PRC2, and is required for the targeting of PRC2 to specific genes for H3K27 tri-methylation and repression. Of the total number of genes affected by Pint inhibition, 39% were upregulated and 61% downregulated upon Pint knockdown. | 24070194 | Lnc2Cancer | ||
| heart failure | N/A | N/A | N/A | expression | Circulating Long Noncoding RNA, LIPCAR, Predicts Survival in Patients With Heart Failure.The mitochondrial long noncoding RNA uc022bqs.1 (LIPCAR) was downregulated early after myocardial infarction but upregulated during later stages. LIPCAR levels identified patients developing cardiac remodeling and were independently to other risk markers associated with future cardiovascular deaths. | 24663402 | LncRNADisease | ||