LncRNA Information
ID EL0676 Name LINC00974 Aliases N/A
Species Homo sapiens Chromosome 17 Start site 41549606
End site 41554495 Chain minus Exon NO. 3
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_038442
Ensembl ENSG00000226629 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
hepatocelluar carcinoma qPCR, in vitro knockdown, RIP etc. HCC tissue, blood(plasma) up-regulated interaction Knockdown of Linc00974 resulted in an inhibition of cell proliferation and invasion with an activation of apoptosis and cell cycle arrest in vitro.The combination of Linc00974 and KRT19 may be novel indices for clinical diagnosis of tumor growth and metastasis in HCC, while Linc00974 may become a potential therapeutic target for the prevention of HCC progression. We also discovered Linc00974F-1 stably expressed in the plasma. 25476897 Lnc2Cancer
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
KRT19 RNA-RNA co-expression Linc00974 was increased owing to an abnormal hypomethylation promoter, which induced the upregulation of KRT19 via ceRNA interaction, resulting in the activation of the Notch and TGF-β pathways as detected by cDNA microarray. 25476897