| Disease |
| Disease |
Method |
Sample |
Expression pattern |
Dysfunction type |
Description |
PMID |
Source |
| osteosarcoma |
microarray, qPCR, FISH etc. |
osteosarcoma tissue, cell lines (U2OS, SAOS-2, HOS etc.) |
down-regulated |
mutation |
These CNAs (copy number alterations) in osteosarcoma often involve the noncoding RNAs LOC285194 and BC040587. |
20048075 |
LncRNADisease Lnc2Cancer
|
| gastric cancer |
microarray, qPCR, knockdown etc. |
gastric cancer tissue |
down-regulated |
N/A |
LncRNA M59227 and 3 mRNAs, PLK1, PTTG1 and VCAN, were overexpressed in GC. In contrast, the expression of 4 lncRNAs, LOC150622, AKR7 L, DQ192290 and BC040587, and 2 mRNAs, DRD5 and GDF5, were downregulated in GC.The results indicated that TUSC7 is a p53-regulated tumour suppressor that acts in part by repressing miR-23b and that TUSC7 may be a key regulatory hub in GC. |
25765901 |
LncRNADisease Lnc2Cancer
|
| breast cancer |
qPCR etc. |
breast cancer tissue, cell lines (ZR-75-30, MCF-7, SKBR-3, T47D cells) |
down-regulated |
expression |
It showed that BC040587 expression was down regulated both in BC samples and in BC cell lines compared with corresponding normal control. BC040587 expression was correlated with menopausal status and tumor differentiation. Furthermore, expression of BC040587 was significantly associated with worse prognosis and was shown to be an independent prognostic marker breast cancer. |
25435812 |
Lnc2Cancer
|
| |