LncRNA Information
ID EL0664 Name LINC00659 Aliases CCAT4; LINC00659-001
Species Homo sapiens Chromosome 20 Start site 62774128
End site 62775412 Chain minus Exon NO. 3
Assembly Ensembl Release 89 Class antisense NCBI accession NR_046225, NR_046224
Ensembl ENSG00000228705 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
colorectal cancer microarray, qPCR, Luciferase reporter assay etc. CRC tissue, cell lines (HCT116, RKO, HT29, SW620 etc.) up-regulated expression Of the seletced lncRNAs, four lncRNAs named CCAT3, CCAT4, CCAT5, and CCAT6 (also named MYCLo-2) are upregulated in CRC cell lines, and two lncRNAs named CCAT7 and CCAT8 are downregulated in CRC cell lines. MYC-regulated lncRNAs, named MYCLos. The MYC-regulated MYCLos may function in cell proliferation and cell cycle by regulating MYC target genes such as CDKN1A (p21) and CDKN2B (p15), suggesting new regulatory mechanisms of MYC-repressed target genes through lncRNAs. 25663692 Lnc2Cancer