LncRNA Information
ID	EL0605	Name	ICR	Aliases	N/A
Species	Homo sapiens	Chromosome	N/A	Start site	N/A
End site	N/A	Chain	N/A	Exon NO.	N/A
Assembly	N/A	Class	N/A	NCBI accession	N/A
Ensembl	N/A	Sequence	N/A

Disease
Disease	Method	Sample	Expression pattern	Dysfunction type	Description	PMID	Source
hepatocelluar carcinoma	microarray, qPCR etc.	HCC tissue, cell lines(CSQT-2, Huh7, Hep3B)	up-regulated	interaction	Compared with the corresponding primary tumors, PVTT expressed different lncRNAs and mRNAs, including the up-regulated lncRNA ICR and ICAM-1. ICR regulated ICAM-1 expression by increasing the stability of its mRNA through RNA duplex formation, which modulated the CSC properties of ICAM-1+ HCC cells. ICR transcription in ICAM-1+ HCC cells was regulated by Nanog and inhibition of ICR in situ significantly reduced ICAM-1 expression and ICAM-1+ HCC cells in tumors in vivo. Moreover, elevated ICR and ICAM-1 expression in tumors was correlated with PVTT development and poor clinical outcomes	26667486	Lnc2Cancer

Interaction
Interaction target	Level of interaction	Type of interaction	Description	PMID	Source
ICAM-1	RNA-RNA	regulation	ICR regulated ICAM-1 expression by increasing the stability of its mRNA through RNA duplex formation.	26667486