LncRNA Information
ID EL0558 Name HAGLR Aliases HOXD-AS1; Mdgt
Species Homo sapiens Chromosome 2 Start site 176173195
End site 176188958 Chain minus Exon NO. 7
Assembly Ensembl Release 89 Class antisense NCBI accession NR_033979, NR_110466, NR_110465, NR_110460, NR_110459, NR_110461, NR_110468, NR_110464, NR_110467, N
Ensembl ENSG00000224189 Sequence

Disease Method Sample Expression pattern Dysfunction type Description PMID Source
neuroblastoma microarray, qPCR, Northern blot, knockdown etc. cell lines (SH-SY5Y) up-regulated regulation One of these lncRNAs, termed HOXD-AS1, is encoded in HOXD cluster. HOXD-AS1 is overexpressed in neuroblastoma. We found that HOXD-AS1 is a subjetc to morphogenic regulation, is activated by PI3K/Akt pathway and itself is involved in control of RA-induced cell differentiation. Knock-down experiments revealed that HOXD-AS1 controls expression levels of clinically significant protein-coding genes involved in angiogenesis and inflammation, the hallmarks of metastatic cancer. 25522241 Lnc2Cancer