LncRNA Information
ID EL0552 Name GSTT1-AS1 Aliases N/A
Species Homo sapiens Chromosome 22 Start site 270138
End site 270389 Chain N/A Exon NO. 1
Assembly GRCh38.p7 Class antisense NCBI accession NR_132348
Ensembl N/A Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
Mycobacterium tuberculosis infection knock-down CD244(+)CD8(+) T-cell line up-regulated expression CD244 expression/signaling in TB correlates with high levels of a long noncoding RNA (lncRNA)-BC050410 [named as lncRNA-AS-GSTT1 (1-72) or lncRNA-CD244] in the CD244(+)CD8(+) T-cell subpopulation. CD244 signaling drives lncRNA-CD244 expression via sustaining a permissive chromatin state in the lncRNA-CD244 locus. 26150504
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
zeste homolog 2 (EZH2) RNA-Protein binding By recruiting polycomb protein enhancer of zeste homolog 2 (EZH2) to infg/tnfa promoters, lncRNA-CD244 mediates H3K27 trimethylation at infg/tnfa loci toward repressive chromatin states and inhibits IFN-γ/TNF-α expression in CD8(+) T cells 26150504