| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL0524 | Name | GAS1RR | Aliases | LncRNA-Hh | |
| Species | Homo sapiens | Chromosome | 9 | Start site | 86948699 | |
| End site | 87002033 | Chain | plus | Exon NO. | 7 | |
| Assembly | Ensembl Release 89 | Class | lincRNA | NCBI accession | NR_049794 | |
| Ensembl | ENSG00000226237 | Sequence | ||||
| Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
| twist-positive breast cancer | microarray, qRT-PCR | Twist-positive mammosphere cells | N/A | interaction | lncRNA-Hh silence in Twist-positive breast cells attenuates the activated Shh-GLI1 signaling and decreases the CSC-associated SOX and OCT4 levels, thus reduces the MFE and tumorigenesis of transplanted tumor. | 26418365 | |||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| Shh-GLI1 | RNA-Protein | regulation | The Shh-GLI1 pathway associated lncRNA-Hh, transcriptionally regulated by Twist, directly targets GAS1 to stimulate the activation of hedgehog signaling (Hh). | 26418365 | |||||