LncRNA Information
ID	EL0357	Name	Dreh	Aliases	N/A
Species	Mus musculus	Chromosome	17	Start site	64767111
End site	64767931	Chain	plus	Exon NO.	2
Assembly	GRCm38.p4	Class	N/A	NCBI accession	NR_105051
Ensembl	N/A	Sequence

Disease
Disease	Method	Sample	Expression pattern	Dysfunction type	Description	PMID	Source
hepatocelluar carcinoma	microarray, qPCR, in vitro knockdown, RIP etc.	HCC tissue	down-regulated	N/A	We identified an lncRNA, down-regulated expression by HBx (termed lncRNA-Dreh), which can inhibit HCC growth and metastasis in vitro and in vivo, act as a tumor suppressor in the development of HBV-HCC. LncRNA-Dreh could combine with the intermediate filament protein vimentin and repress its expression, further change the normal cytoskeleton structure to inhibit tumor metastasis.	23239537	Lnc2Cancer
hepatocelluar carcinoma	N/A	N/A	N/A	regulation	Further experiments showed that Dreh can specifically bind to vimentin, a type III intermediate filament and the major cytoskeletal component of mesenchymal cells and then inhibit HCC metastasis by modifying the expression and reorganization of vimentin.	24296588	LncRNADisease
hepatocelluar carcinoma	N/A	N/A	N/A	regulation	lncRNA-Dreh could bind to the intermediate filament protein vimentin, repress its expression, and thus change the cytoskeleton structure and inhibit tumor metastasis. It acts as a tumor suppressor in the development of HBV-HCC, which inhibits HCC growth and metastasis?in vitro?and?in vivo. These findings support a role of lncRNA-Dreh in tumor suppression and survival prediction of HCC patients.	24757675	LncRNADisease